US3877843A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pulsatile pumping system
Assignee: Baxter International Inc
•
Filing: 1973-05-21
•
Granted: 1975-04-15
•
Expires: 1993-05-21
Abstract
Abstract A portable pulsatile pumping system simulates the pumping mechanism of a human heart in pumping fluid for such applications as organ perfusion systems. The pumping system includes a regulated source of pressurized gas, a pulsatile pump having an aorta chamber providing a sustained minimum diastolic pressure and a ventricle chamber providing a higher systolic pressure during a selectively variable part (1 to 99 percent) of each cyclic pumping action, the periodicity of which may be varied from 5 to 150 cycles per minute. The gas source is connected to the pump by a first adjustable pressure regulator to maintain the chosen diastolic pressure in the aorta chamber. The ventricle chamber is alternately coupled to gas pressure taken through a second pressure regulator and vented by a solenoid mechanism operated by a digital electronic timing control circuit. The digital electronic control system employs digital counters and selector switches to generate square wave pulses of varying duration and periodicity in a manner which provides both conservation of electrical battery energy and high reliability. At the same time, an optimum pumping system is achieved because the elasticity of the gas and connecting tubing are employed to smooth the sharp signal transitions.
Inventors
- 👤 Halbert Fischel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:00
CPC Classifications
F; F04; F04B; F04B49/00; F04B49/06; A; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/142; A01N1/143; A01N1/16; A01N1/165; A61; A61M; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/30; A61M60/36; A61M60/38; A61M60/40; A61M60/424; A61M60/427; A61M60/80; A61M60/845; A61M60/851; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
177 words
A system for providing a selectively controllable pulsatile flow of a perfusate to simulate cardiac action comprising: a pulsatile perfusate pump which comprises flexible chamber means, said means being collapsible in response to applied fluid pressure, to pump perfusate in said chamber means through a flow line in pulsatile manner; at least one fluid pressure means; adjustable systolic pressure regulator means coupled to said fluid pressure means; first conduit means including control signal responsive valving means coupling said systolic pressure regulator means to said ventricle chamber means; and electronic control means including adjustable means for generating square wave control signals of adjustable duration and repetition rate, the square waves having sharp rise and fall times, wherein said valving means comprises a two output valve having a venting output and an output communicating with said perfusate pump, wherein said fluid pressure means comprises a pressure storage vessel, and wherein said electronic control means comprises counter means adjustable to provide valving means controlling outputs at selected counts, said counter means being adapted to count said square wave control signals.
Claim 2
Independent Claim
177 words
A system for providing a selectively controllable pulsatile flow of a perfusate to simulate cardiac action comprising: a pulsatile perfusate pump which comprises flexible chamber means, said means being collapsible in response to applied fluid pressure, to pump perfusate in said chamber means through a flow line in pulsatile manner; at least one fluid pressure means; adjustable systolic pressure regulator means coupled to said fluid pressure means; first conduit means including control signal responsive valving means coupling said systolic pressure regulator means to said ventricle chamber means; and electronic control means including adjustable means for generating square wave control signals of adjustable duration and repetition rate, the square waves having sharp rise and fall times, wherein said valving means comprises a two output valve having a venting output and an output communicating with said perfusate pump, wherein said fluid pressure means comprises a pressure storage vessel, and wherein said electronic control means comprises counter means adjustable to provide valving means controlling outputs at selected counts, said counter means being adapted to count said square wave control signals.
Claim 3
Dependent Claim
30 words
The invention as set forth in claim 1 above, wherein said first and second conduit means comprise small diameter resilient tubing, and wherein the applied fluid under pressure is air.
Claim 4
Dependent Claim
212 words
A combination electronic pneumatic pump control system for gently controlling a pulsatile pump maintaining a first output pressure and producing a periodically occurring systolic output pressure greater than the first pressure in response to a periodically occurring fluid drive pressure comprising: a selectivelY venting pressure control valve having an input connectable to a drive fluid pressure source under control of a transducer; a conduit connected to the outlet of the pressure control valve to a fluid operated pulsatile pump for providing operating fluid to said pump, said conduit restricting the flow of drive fluid therethrough; a transducer connected to control said pressure control valve to selectively connect the outlet to said pressure source in response to first and second states respectively of an electronic digital control signal having sharp transitions between states; and an electronic digital control circuit providing an electronic digital control signal to the transducer, said control circuit including a recycling counter, means responsive to the counter for switching the electronic digital control signal to a first state when the counter reaches a first selected count, and means for switching the electronic digital control signal to a second state when the counter reaches a second selected count, each state being present during a selected variable proportion of each control signal.
Claim 5
Dependent Claim
212 words
A combination electronic pneumatic pump control system for gently controlling a pulsatile pump maintaining a first output pressure and producing a periodically occurring systolic output pressure greater than the first pressure in response to a periodically occurring fluid drive pressure comprising: a selectivelY venting pressure control valve having an input connectable to a drive fluid pressure source under control of a transducer; a conduit connected to the outlet of the pressure control valve to a fluid operated pulsatile pump for providing operating fluid to said pump, said conduit restricting the flow of drive fluid therethrough; a transducer connected to control said pressure control valve to selectively connect the outlet to said pressure source in response to first and second states respectively of an electronic digital control signal having sharp transitions between states; and an electronic digital control circuit providing an electronic digital control signal to the transducer, said control circuit including a recycling counter, means responsive to the counter for switching the electronic digital control signal to a first state when the counter reaches a first selected count, and means for switching the electronic digital control signal to a second state when the counter reaches a second selected count, each state being present during a selected variable proportion of each control signal.
Claim 6
Dependent Claim
35 words
The pump control system as set forth in claim 3 above, wherein the conduit includes at least one elastically expansible portion which absorbs energy as it expands in response to a pressurized drive fluid therein.
Claim 7
Dependent Claim
19 words
The pump control system as set forth in claim 4 above, wherein the drive fluid is an expandable gas.
Claim 8
Dependent Claim
18 words
The pump control system as set forth in claim 5 above, wherein the drive fluid is compressed air.
Claim 9
Dependent Claim
27 words
The pump control system as set forth in claim 3 above, wherein at least one of said first and second counts is selectively variable under operator control.
Claim 10
Dependent Claim
114 words
The pump control system as set forth in claim 5 above, wherein the electronic digital control circuit includes an oscillator generating a clock signal at a selectively variable frequency; a recycling counter connected to count cycles of the clock signal; means responsive to the counter for generating first and second intermediate control signals in response to first and second counts of the counter respectively, said control signal generating means including means for selectively varying the count at which at least the first intermediate control signal is generated; and means connected to switch the electronic digital control signal to the first and second states in response to the first and second intermediate control signals respectively.
Claim 11
Independent Claim
236 words
A system for providing a selectively controllable pulsatile flow of a perfusate to simulate cardiac action, the flow having selectable diastolic and systolic intervals and pressures comprising: a pulsatile perfusate pump having at least a pair of pump chamber means responsive to applied fluid pressures; means providing diastolic and systolic fluid pressures; conduit means providing substantial impedance to fluid flow and coupling each of said diastolic and systolic pressure means to a different chamber of said perfusate pump; signal responsive valving means coupled into the conduit means coupling the systolic pressure means to the perfusate pump; and electronic control signal generating means coupled to said valving means and including means for generating a systole control signal of controllable duration and repetition rates, to provide control signals to said signal responsive valving means, said systole control signal means comprising an electronic digital control circuit which includes an oscillator for generating a clock signal at a selectively variable frequencies; a recycling counter connected to count cycles of the clock signal; means responsive through the counter for generating first and second intermediate control signals in response to the first and second counts of the counter respectively, said control signal generating means including means for selectively varying the count in which at least the first intermediate control signal is generated; and means for altering the signal responsiVe valving means in response to the first and second intermediate control signals respectively.
Claim 12
Independent Claim
236 words
A system for providing a selectively controllable pulsatile flow of a perfusate to simulate cardiac action, the flow having selectable diastolic and systolic intervals and pressures comprising: a pulsatile perfusate pump having at least a pair of pump chamber means responsive to applied fluid pressures; means providing diastolic and systolic fluid pressures; conduit means providing substantial impedance to fluid flow and coupling each of said diastolic and systolic pressure means to a different chamber of said perfusate pump; signal responsive valving means coupled into the conduit means coupling the systolic pressure means to the perfusate pump; and electronic control signal generating means coupled to said valving means and including means for generating a systole control signal of controllable duration and repetition rates, to provide control signals to said signal responsive valving means, said systole control signal means comprising an electronic digital control circuit which includes an oscillator for generating a clock signal at a selectively variable frequencies; a recycling counter connected to count cycles of the clock signal; means responsive through the counter for generating first and second intermediate control signals in response to the first and second counts of the counter respectively, said control signal generating means including means for selectively varying the count in which at least the first intermediate control signal is generated; and means for altering the signal responsiVe valving means in response to the first and second intermediate control signals respectively.
Claim 13
Dependent Claim
249 words
For use in an organ perfusion system circulating a perfusate through an organ, a pulsatile pumping system comprising: a pump connected to receive perfusate in an inlet and deliver perfusate in an outlet, said pump including first and second control fluid inlets and providing a first perfusate pressure at the outlet in response to a high control fluid pressure at the first control fluid inlet and a second perfusate pressure at the outlet in response to a low control fluid pressure at a second control fluid inlet in the absence of the high control fluid pressure at the first control fluid inlet; means for connecting the first control fluid inlet to a high pressure control fluid source in response to a first electrical signal condition and disconnecting the first control fluid inlet in response to a second electrical signal condition; a timing control circuit coupled to said means for connecting for providing a bistate electrical signal of selectable periodicity having alternate first and second electrical signal conditions, the control circuit including means responsive to operator control for selecting the relative durations of the first and second electrical signal conditions during each period, in which said timing control circuit comprises an electronic digital control circuit including a recycling counter, means responsive to the counter for assuming the first electrical signal condition when the counter reaches a first selected count, and means responsive to the counter for assuming the second electronic signal condition when the counter reaches a second selected count.
Claim 14
Dependent Claim
249 words
For use in an organ perfusion system circulating a perfusate through an organ, a pulsatile pumping system comprising: a pump connected to receive perfusate in an inlet and deliver perfusate in an outlet, said pump including first and second control fluid inlets and providing a first perfusate pressure at the outlet in response to a high control fluid pressure at the first control fluid inlet and a second perfusate pressure at the outlet in response to a low control fluid pressure at a second control fluid inlet in the absence of the high control fluid pressure at the first control fluid inlet; means for connecting the first control fluid inlet to a high pressure control fluid source in response to a first electrical signal condition and disconnecting the first control fluid inlet in response to a second electrical signal condition; a timing control circuit coupled to said means for connecting for providing a bistate electrical signal of selectable periodicity having alternate first and second electrical signal conditions, the control circuit including means responsive to operator control for selecting the relative durations of the first and second electrical signal conditions during each period, in which said timing control circuit comprises an electronic digital control circuit including a recycling counter, means responsive to the counter for assuming the first electrical signal condition when the counter reaches a first selected count, and means responsive to the counter for assuming the second electronic signal condition when the counter reaches a second selected count.
References Cited (Backward Citations)
US3266487A
Cited
US3376660A
Cited
US3430624A
Cited
US3516331A
Cited
US3545221A
Cited
US3639084A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-04-14 | 1978-10-14 | 1979-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-04-14 | 1982-10-14 | 1983-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-04-14 | 1986-10-14 | 1987-04-15 | $7700.00 | Window Closed / Lapsed |