US3865726A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood urea removal device
Assignee: Tanabe Pharma Corp
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Filing: 1973-10-05
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Granted: 1975-02-11
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Expires: 1993-10-05
Abstract
Abstract A blood urea removal device which comprises a fluid passage having a blood inlet at one end and a blood outlet at both ends, a means for feeding a fumarate-containing solution and a column packed with an enzyme preparation provided in the passage, the enzyme preparation being microcapsules containing urease and/or aspartase in a membrane gel lattice of semi-permeable high polymeric substance.
Inventors
- 👤 Ichiro Chibata
- 👤 Tetsuya Tosa
- 👤 Tadashi Sato
- 👤 Takao Mori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:21
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/04; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3687; B; B01; B01D; B01D69/00; B01D69/14; B01D69/141; B01D69/142; B01D69/144; A61M2202/00; A61M2202/04; A61M2202/0496; A61M2202/0498
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
85 words
A BLOOD UREA REMOVAL DEVICE WHICH CONSISTS ESSENTIALLY OF A FLUID PASSAGE HAVING AN INLET AT ONE END AND AN OUTLET AT THE OTHER END, A COLUMN PACKED WITH AN ENZYME PREPARATION IN THE PASSAGE, AND A MEANS FOR FEEDING A FUMARATE-CONTAINING SOLUTION CONNECTED TO SAID FLUID PASSAGE UPSTREAM OF SAID COLUMN, THE ENZYME PREPARATION BEING MICROCAPSULES CONTAINING UREASE IN A MEMBRANE OR GEL LATTICE OF SEMI-PREMEABLE HIGH POLYMERIC SUBSTANCE AND MICROCAPSULES CONTAINING ASPARTASE IN A MEMBRANE OR GEL LATTICE OF SEMI-PERMEABLE HIGH POLYMERIC SUBSTANCE.
Claim 2
Dependent Claim
85 words
A BLOOD UREA REMOVAL DEVICE WHICH CONSISTS ESSENTIALLY OF A FLUID PASSAGE HAVING AN INLET AT ONE END AND AN OUTLET AT THE OTHER END, A COLUMN PACKED WITH AN ENZYME PREPARATION IN THE PASSAGE, AND A MEANS FOR FEEDING A FUMARATE-CONTAINING SOLUTION CONNECTED TO SAID FLUID PASSAGE UPSTREAM OF SAID COLUMN, THE ENZYME PREPARATION BEING MICROCAPSULES CONTAINING UREASE IN A MEMBRANE OR GEL LATTICE OF SEMI-PREMEABLE HIGH POLYMERIC SUBSTANCE AND MICROCAPSULES CONTAINING ASPARTASE IN A MEMBRANE OR GEL LATTICE OF SEMI-PERMEABLE HIGH POLYMERIC SUBSTANCE.
Claim 3
Dependent Claim
37 words
A blood urea removal device as claimed in claim 1 in which the microcapsules containing urease are toward the upstream end of said column, and the microcapsules containing aspartase are toward the downstream end of said column.
Claim 4
Dependent Claim
47 words
A blood urea removal device as claimed in claim 1 further comprising a dialyzer in said fluid passage downstream of said column, the dialyzer having a dialysate circulating passage and a further column packed with ion exchange resin and a circulation pump in said dialysate circulating passage.
Claim 5
Dependent Claim
80 words
A blood urea removal device as claimed in claim 1 further comprising a dialyzer having a dialysate circulating passage, the inlet and outlet of said fluid passage being connected to said dialysate circulating passage for feeding solution through said dialyzer from said fluid passage and from said dialyzer back into said fluid passage, an ion exchange column packed with ion exchange resin connected in said fluid passage downstream of said column, and a circulation pump connected in the fluid passage.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-10 | 1978-08-12 | 1979-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-10 | 1982-08-12 | 1983-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-10 | 1986-08-12 | 1987-02-11 | $7700.00 | Window Closed / Lapsed |