US3863004A
Expired / Lapsed
US
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Denatured macroprotein with divalent tin for tagging with technetium-99m and method of preparation
Assignee: Mallinckrodt Chemical Works
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Filing: 1972-03-20
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Granted: 1975-01-28
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Expires: 1992-03-20
Abstract
Abstract An improved composition suitable for tagging with technetium-99m and use in lung scanning procedures consists essentially of an injectable suspension in buffer solution of particles of a denatured macroprotein having divalent tin bound thereto. The macroprotein has a molecular weight of at least about 20,000. A method for preparing the injectable suspension by treating macroaggregates or microspheres of a denatured macroprotein with a solution containing divalent tin ions is also provided.
Inventors
- 👤 Robert G Wolfangel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/12; A61K51/1217; A61K51/1241; A61K51/1255; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
24 words
A composition as set forth in claim 1 wherein the pH of said buffer solution is approximately the isoelectric pH of said denatured macroprotein.
Claim 2
Dependent Claim
18 words
A composition as set forth in claim 1 wherein said macroprotein comprises particles of macroaggregated human serum albumin.
Claim 3
Dependent Claim
23 words
A composition as set forth in claim 1 wherein the size of the particles is substantially between about 5 and about 80 microns.
Claim 4
Dependent Claim
23 words
A composition as set forth in claim 4 wherein the mean size of said particles is between about 15 and about 30 microns.
Claim 5
Dependent Claim
16 words
A composition as set forth in claim 1 including macroprotein particles in the form of microspheres.
Claim 6
Dependent Claim
39 words
A composition as set forth in claim 1 wherein the buffer solution contains between about 8 % and about 16 % by weight of an antiagglomerating agent selected from the group consisting of propylene glycol, sucrose, glycerin and gelatin.
Claim 7
Dependent Claim
80 words
A process for preparing a buffered injectable suspension of particles of denatured macroprotein suitable for rapid tagging with technetium-99m and use in lung scanning procedures comprising the steps of: contacting particles of a denatured macroprotein with a solution containing a water-soluble salt of divalent tin causing divalent tin to be bound to said macroprotein; washing the macroprotein having divalent tin bound thereto with a buffer solution; and thereafter suspending in a buffer solution the macroprotein having divalent tin bound thereto.
Claim 8
Dependent Claim
15 words
A process as set forth in claim 8 wherein said macroprotein is human serum albumin.
Claim 9
Dependent Claim
21 words
A process as set forth in claim 8 wherein said solution containing divalent tin ions is a solution of stannous chloride.
Claim 10
Dependent Claim
24 words
A process as set forth in claim 10 wherein said solution contains approximately 3 mg. of divalent tin for each 100 mg. of macroprotein.
Claim 11
Dependent Claim
17 words
A process as set forth in claim 8 wherein said macroprotein is in the form of macroaggregates.
Claim 12
Dependent Claim
17 words
A process as set forth in claim 8 wherein said macroprotein is in the form of microspheres.
Claim 13
Dependent Claim
31 words
A process as set forth in claim 8 wherein said macroprotein is prepared by precipitating denatured macroprotein in an acid medium at a pH approximately the isoelectric pH of said protein.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-01-27 | 1978-07-29 | 1979-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-01-27 | 1982-07-29 | 1983-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-01-27 | 1986-07-29 | 1987-01-28 | $7700.00 | Window Closed / Lapsed |