Abstract In the course of a biochemical analysis, microliter volumes of a reagent and a sample are mixed with one another for reaction. Such volumes are obtained by use of two respectively dimensioned identical plates, being provided with cavities on those faces, which are to contact the other one. When said two plates are brought in close contact, said cavities, being loaded with samples or reagents, form reaction cells. The mixture is obtained by vibrating the entire device. Each cavity may be surrounded by circular grooves for preventing confluence of solutions from neighbouring cavities. Alternatively, the contact faces of the plates, being provided with said cavities and said grooves, are smoothly covered by conformal foils, which are used for one test operation only, and are thrown away thereafter.
A DEVICE FOR CARRYING OUT BIOCHEMICAL ANALYSIS IN THE ULTRA-MICRO RANGE, PARTICULARLY FOR MIXING MICRO-VOLUMES OF AT LEAST ONE SAMPLE WITH AT ONE REAGENT, COMPRISING TWO PLATES FOR BEING ASSEMBLED IN CLOSE CONTACT ON ONE ANOTHER, EACH OF SAID TWO PLATES HAVING A CONTACT FACE BEING PROVIDED WITH CAVITIES OF SUBSTANTIALLY THE SAME SIZE; THE CAVITIES IN THE ONE OF SAID TWO PLATES RECEIVING THE SAMPLE; THE CAVITIES IN THE OTHER OF SAID TWO PLATES RECEIVING THE REAGENT; SAID TWO PLATES BEING ASSEMBLED AND SAID CAVITIES BEING ARRANGED IN A MANNER THAT THE CAVITIES IN THE ONE OF SAID PLATES REGISTER WITH THE CAVITIES IN THE OTHER OF SAID PLATES, THUS FORMNG REACTION CELLS, ONE VIBRATOR, AND CLAMPING MEANS FOR ENSURING THE SECURE MOUNT OF THE ASSEMBLED PLATES ON SAID VIBRATOR, SAID VIBRATOR BEING ADAPTED TO SHAKE THE ASSEMBLED PLATES AND TO MIX SAID SAMPLE AND SAID REAGENT, BOTH ENCLOSED THEREIN.
Claim 2
Independent Claim
151 words
A DEVICE FOR CARRYING OUT BIOCHEMICAL ANALYSIS IN THE ULTRA-MICRO RANGE, PARTICULARLY FOR MIXING MICRO-VOLUMES OF AT LEAST ONE SAMPLE WITH AT ONE REAGENT, COMPRISING TWO PLATES FOR BEING ASSEMBLED IN CLOSE CONTACT ON ONE ANOTHER, EACH OF SAID TWO PLATES HAVING A CONTACT FACE BEING PROVIDED WITH CAVITIES OF SUBSTANTIALLY THE SAME SIZE; THE CAVITIES IN THE ONE OF SAID TWO PLATES RECEIVING THE SAMPLE; THE CAVITIES IN THE OTHER OF SAID TWO PLATES RECEIVING THE REAGENT; SAID TWO PLATES BEING ASSEMBLED AND SAID CAVITIES BEING ARRANGED IN A MANNER THAT THE CAVITIES IN THE ONE OF SAID PLATES REGISTER WITH THE CAVITIES IN THE OTHER OF SAID PLATES, THUS FORMNG REACTION CELLS, ONE VIBRATOR, AND CLAMPING MEANS FOR ENSURING THE SECURE MOUNT OF THE ASSEMBLED PLATES ON SAID VIBRATOR, SAID VIBRATOR BEING ADAPTED TO SHAKE THE ASSEMBLED PLATES AND TO MIX SAID SAMPLE AND SAID REAGENT, BOTH ENCLOSED THEREIN.
Claim 3
Dependent Claim
18 words
Device as claimed in claim 1, wherein said cavities in said two plates being concentrically surrounded by grooves.
Claim 4
Dependent Claim
36 words
Device as claimed in claim 2, wherein at least one of the contact faces of said two plates is conformally covered by a foil, thus possessing indentations, corresponding to the cavities in the one contact face.