US3857932A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants
Assignee: Individual
•
Filing: 1972-06-27
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Granted: 1974-12-31
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Expires: 1992-06-27
Abstract
Abstract A shaped body in vivo implantation dosage form which is a dry composition containing a therapeutically active material and a water insoluble hydrophilic acrylate or methacrylate polymer selected from the group consisting of polymers of hydroxy lower alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates and hydroxy lower alkoxy lower alkyl methacrylates, said shaped body being formed by casting or molding an anhydrous casting syrup or solution of the therapeutic material and the hydrophilic acrylate or methacrylate and polymerizing the composition, the resulting cast or molded dosage form having the advantage of preventing deterioration or loss of potency and thereby extending the shelf life of the therapeutic.
Inventors
- 👤 F Gould
- 👤 T Shepherd
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; B; B29; B29L; B29L2031/00; B29L2031/753; B29L2031/7532
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
109 words
A SHAPE BODY IN VIVO IMPLANTATION DOSAGE FORM WHICH IS A DRY COMPOSITION CONTAINING A THERAPCEUTICALLY ACTIVE MATERIAL AND WATER INSOLUBLE HYDROPHILLIC ACRYLATE OR METHACRYLATE POLYMER SELECTED FROM THE GROUP CONSISTING GROUP OF POLYMERS OF HYDROXY LOWER ALKYL ACRYLATES, HYDROXY LOWER ALKYL METHACRYLATES, HYDROXY LOWER ALKOXY LOWER ALKYL ACRYLATES AND HYDROXY LOWER ALKOXY LOWER ALKYL METHACRYLATES, SAID SHAPED BODY BEING FORMED BY CASTING OR MOLDING AN ANHYDROUS CASTING SYRUP OR SOLUTION OF THE THERAPEUTIC MATERIAL AND THE HYDROPHILIC ACRYLATE OR METHYACRYLATE AD TION, THE RESULTING CAST OR MOLDED DOSAGE FORM HAVING THE ADVANTAGE OF PREVENTING DETERIORATION OR LOSS OR POTENCY AND THEREBY EXTENDING THE SHELF LIFE OF THE THERAPEUTIC.
Claim 2
Dependent Claim
109 words
A SHAPE BODY IN VIVO IMPLANTATION DOSAGE FORM WHICH IS A DRY COMPOSITION CONTAINING A THERAPCEUTICALLY ACTIVE MATERIAL AND WATER INSOLUBLE HYDROPHILLIC ACRYLATE OR METHACRYLATE POLYMER SELECTED FROM THE GROUP CONSISTING GROUP OF POLYMERS OF HYDROXY LOWER ALKYL ACRYLATES, HYDROXY LOWER ALKYL METHACRYLATES, HYDROXY LOWER ALKOXY LOWER ALKYL ACRYLATES AND HYDROXY LOWER ALKOXY LOWER ALKYL METHACRYLATES, SAID SHAPED BODY BEING FORMED BY CASTING OR MOLDING AN ANHYDROUS CASTING SYRUP OR SOLUTION OF THE THERAPEUTIC MATERIAL AND THE HYDROPHILIC ACRYLATE OR METHYACRYLATE AD TION, THE RESULTING CAST OR MOLDED DOSAGE FORM HAVING THE ADVANTAGE OF PREVENTING DETERIORATION OR LOSS OR POTENCY AND THEREBY EXTENDING THE SHELF LIFE OF THE THERAPEUTIC.
Claim 3
Dependent Claim
81 words
A shaped body in vivo implantation dosage form according to claim 1 providing prolonged release of a medicament comprising a medicament hOmogeneously dispersed in a copolymer of a major amount of 2-hydroxyethyl methacrylate and a minor amount of ethylene glycol dimethacrylate, wherein said copolymer is molded in the form of the shaped body by in situ mold polymerization of an anhydrous solution of said monomers with said medicament dissolved therein, in the presence of a catalytic quantity of a polymerization initiator.
Claim 4
Dependent Claim
15 words
A shaped body according to claim 1 which is in the form of a cylinder.
Claim 5
Dependent Claim
14 words
A shaped body according to claim 1 wherein the polymer is organic solvent soluble.
Claim 6
Dependent Claim
82 words
A solid rod shaped polymer suitable as an in vivo body implant to provide prolonged release of a medicament comprising a medicament homogeneously dispersed in a copolymer of a major amount of 2-hydroxyethyl methacrylate and a minor amount of ethylene glycol dimethacrylate, wherein said copolymer is molded in the form of the shaped body by in situ mold polymerization of an anhydrous solution of said monomers with said medicament dissolved therein, in the presence of a catalytic quantity of a polymerization initiator.
Claim 7
Dependent Claim
82 words
A solid rod shaped polymer suitable as an in vivo body implant to provide prolonged release of a medicament comprising a medicament homogeneously dispersed in a copolymer of a major amount of 2-hydroxyethyl methacrylate and a minor amount of ethylene glycol dimethacrylate, wherein said copolymer is molded in the form of the shaped body by in situ mold polymerization of an anhydrous solution of said monomers with said medicament dissolved therein, in the presence of a catalytic quantity of a polymerization initiator.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-30 | 1978-07-01 | 1978-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-30 | 1982-07-01 | 1982-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-30 | 1986-07-01 | 1986-12-31 | $7700.00 | Window Closed / Lapsed |