US3833796A
Expired / Lapsed
US
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Method and apparatus for chromosome digitizing
Assignee: Georgia Tech Research Institute
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Filing: 1971-10-13
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Granted: 1974-09-03
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Expires: 1991-10-13
Abstract
Abstract A chromatizer including an apparatus for and method of effecting the analysis of chromosomes including means for establishing an image of at least one chromosome, means for digitizing the distance each arm of the chromosome is from a preselected reference point, and means for automatically computing a number of quantitative measurements of the chromosome, including the length of each arm and the centromere index. The digitizing means includes means for identifying and recording the location of a plurality of points along each arm of the chromosome relative to the reference point. The establishing means includes means for superimposing the identifying means onto the image of the chromosome. The computing means includes means for displaying the computed quantitative measurements.
Inventors
- 👤 R Fetner
- 👤 J Alderman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:53
CPC Classifications
G; G06; G06V; G06V20/00; G06V20/60; G06V20/69
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
70 words
A method for the automatic characterization of chromosomes, comprising the steps of: a. displaying an image of a chromosome; b. locating a reference point on said chromosome; c. registering the location of said reference point; d. advancing an identifying means from the distal end of each of the arms of said chromosome to approximate engagement with said reference point; and e. computing the effective length of each of said arms.
Claim 2
Independent Claim
70 words
A method for the automatic characterization of chromosomes, comprising the steps of: a. displaying an image of a chromosome; b. locating a reference point on said chromosome; c. registering the location of said reference point; d. advancing an identifying means from the distal end of each of the arms of said chromosome to approximate engagement with said reference point; and e. computing the effective length of each of said arms.
Claim 3
Dependent Claim
18 words
A method as described in claim 1, including the step of superimposing said identifying means onto said image.
Claim 4
Dependent Claim
19 words
A method as described in claim 1, including the step of detecting a plurality of points along said arm.
Claim 5
Dependent Claim
22 words
A method as described in claim 3, including the step of recording the location of said points relative to said reference point.
Claim 6
Dependent Claim
17 words
A method as described in claim 4, including the step of converting said points into coordinate pairs.
Claim 7
Dependent Claim
18 words
A method as described in claim 5, including the step of computing the centromere index for said chromosome.
Claim 8
Dependent Claim
19 words
A method as described in claim 6, wherein said image includes a plurality of chromosomes of a particular cell.
Claim 9
Dependent Claim
22 words
A method as described in claim 7, including the step of computing the arm ratio and the length ratio of said chromosomes.
Claim 10
Dependent Claim
19 words
A method as described in claim 8, including the step of plotting said arm ratio versus said length ratio.
Claim 11
Dependent Claim
25 words
A method as described in claim 9, including the step of recording said effective length, said arm ratio, said length ratio, and said centromere index.
Claim 12
Independent Claim
87 words
An apparatus for the automatic characterization of chromosomes, comprising in combination: means for displaying an image of a chromosome; manual selection means for selective registration with discrete pointS of said image; means for identifying a plurality of points selected by said manual selection means along the length of each of the arms of said chromosomes relative to a reference point on said chromosome; and means for computing the effective length of each of said arms from said plurality of points identified with respect to said reference point.
Claim 13
Independent Claim
87 words
An apparatus for the automatic characterization of chromosomes, comprising in combination: means for displaying an image of a chromosome; manual selection means for selective registration with discrete pointS of said image; means for identifying a plurality of points selected by said manual selection means along the length of each of the arms of said chromosomes relative to a reference point on said chromosome; and means for computing the effective length of each of said arms from said plurality of points identified with respect to said reference point.
Claim 14
Dependent Claim
14 words
An apparatus as described in claim 11 wherein said image is a microscopic image.
Claim 15
Dependent Claim
14 words
An apparatus as described in claim 11 wherein said image is a photographic image.
Claim 16
Dependent Claim
17 words
An apparatus as described in claim 11 wherein said reference point is the centromere of said chromosome.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-09-02 | 1978-03-04 | 1978-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-09-02 | 1982-03-04 | 1982-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-09-02 | 1986-03-04 | 1986-09-03 | $7700.00 | Window Closed / Lapsed |