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US3728449A Expired / Lapsed US ⏱️ 0.0 years remaining

Germicidal iodine compositions for application to skin tissue including teats of milk animals

Assignee: West Agro Inc
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Filing: 1972-05-01
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Granted: 1973-04-17
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Expires: 1992-05-01
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Abstract

Abstract An improved germicidal-iodine composition for application to skin tissue and particularly to teats of milk animals in the control of mastitis, wherein an aqueous nonionic carrier-iodine composition providing available iodine concentration in the range of about 0.25 to 2 percent, and containing nonionic carriers of the types which have been cleared for use in contact with food equipment in an amount providing a ratio of carrier to available iodine within the range of 5:1 to 20:1, is supplemented by an emollient in the form of a water-soluble polyhydric alcohol or ethoxylated lanolin, and the emollient is protected against reaction with the iodine by providing a suitably high distribution coefficient for the iodine and maintaining a pH in the composition in the range of about pH 3 - 6.5, and preferably buffered at about pH 3.5 - 4.5. Buffering can be effected by various food acids and salts of food acids.

Inventors

  • 👤 A Cantor
  • 👤 M Winicov

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 00:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0041; A01; A01N; A01N59/00; A01N59/12

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 28 words
A germicidal composition as defined in claim 1 wherein said polyhydric alcohols are members selected from the group consisting of glycerin, propylene glycol, mannitol, sorbitol, and mixtures thereof.
Claim 2
Dependent Claim 46 words
A germicidal composition as defined in claim 1 wherein said available iodine is present as elemental iodine in association with a water soluble inorganic iodide in an amount to provide at least 0.35 parts by weight of iodide (I ) per part by weight of iodine.
Claim 3
Dependent Claim 27 words
A germicidal composition as defined in claim 1 wherein said sustained pH is provided by buffering agents comprising any of the recognized food acids and mixtures thereof.
Claim 4
Dependent Claim 39 words
A germicidal composition as defined in claim 4 wherein the quantity of buffering agent is such as to provide a 0.02 - 0.25 molar buffer content, and the pH is buffered within the range of pH 3.5 to 4.5.
Claim 5
Dependent Claim 27 words
A germicidal compositiOn as defined in claim 1 wherein the emollient is a polyhydric alcohol and is present in the amount of about 10 percent by weight.
Claim 6
Dependent Claim 13 words
A germicidal composition as defined in claim 6 wherein the emollient is glycerin.
Claim 7
Dependent Claim 13 words
A germicidal composition as defined in claim 6 wherein the emollient is sorbitol.
Claim 8
Dependent Claim 14 words
A germicidal composition as defined in claim 6 wherein the emollient is propylene glycol.
Claim 9
Dependent Claim 13 words
A germicidal composition as defined in claim 6 wherein the emollient is mannitol.
Claim 10
Dependent Claim 28 words
A germicidal composition as defined in claim 1 wherein the emollient is ethoxylated lanolin and is present in the amount of about 2 to 3 percent by weight.
Claim 11
Dependent Claim 308 words
A germicidal composition for application to skin tissue and particularly to teats of milk animals in the control of mastitis, said composition consisting essentially of an aqueous solution containing available iodine in the amount of about 0.25 to 2 percent by weight, said iodine being complexed with a nonionic iodine carrier selected from the group consisting of a. alkyl phenol ethylene oxide condensates wherein the alkyl group contains 8-12 carbon atoms and the condensate contains about 7-18 mols of ethylene oxide per mol of alkyl phenol, b. nonionics embraced by the formula: HO(C2H4O)x(C3H6O)y(C2H4O)x -H wherein y equals at least 15 and (C2H4O)x x equals 20 to 90 percent of the total weight of said compound, c. nonionics which are ethoxylated partial esters of fatty acids with sugar alcohols containing an average of 1 - 3 ester groups and up to 50 mols of ethylene oxide per molecule, d. butoxy derivatives of polyethylene oxide, ethylene oxide, block polymers having molecular weights within the range of about 2,000 - 5,000, e. poly(N-vinyl-2-pyrrolidone), and f. mixtures thereof, said iodine carrier being present in an amount to provide a ratio of carrier to available iodine within the range of 5:1 to 20:1, an emollient selected from the group consisting of polyhydric alcohols, water soluble ethoxylated lanolin, and mixtures thereof, said polyhydric alcohols being present in an amount of about 5 to 25 percent of said composition and said water soluble ethoxylated lanolin being present in an amount of about 1 to 10 percent of said composition, said solution having a sustained pH in the range of about pH 3 - 6.5 and containing sufficient inorganic iodide to provide a distribution coefficient sufficiently high to satisfy the formula: D.C. number/Percent available iodine at least 75, said pH range and said distribution coefficient serving to prevent said emollient from reacting with said available iodine.

References Cited (Backward Citations)

US3028299A Cited
US3285816A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1976-04-16 1976-10-16 1977-04-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1980-04-16 1980-10-16 1981-04-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1984-04-16 1984-10-16 1985-04-17 $7700.00 Window Closed / Lapsed

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