US3728445A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release medicament
Assignee: Controlled Medications Ltd
•
Filing: 1970-10-19
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Granted: 1973-04-17
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Expires: 1990-10-19
Abstract
Abstract The invention relates to novel extended-release medicament preparations, particularly in tablet form, and to a method of preparing same. The preparations of the invention are based on the desired medicament, an excipient such as a sugar, a defined class of binder and a ''''barrier'''' salt such as magnesium stearate.
Inventors
- 👤 F Bardani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
16 words
A method as claimed in claim 1 wherein the calcium or magnesium salt is a stearate.
Claim 2
Dependent Claim
21 words
A method as claimed in claim 1 wherein the excipient is lactose and the calcium or magnesium salt is magnesium stearate.
Claim 3
Dependent Claim
21 words
A method as claimed in claim 1 wherein the excipient is sucrose and the calcium or magnesium salt is magnesium stearate.
Claim 4
Dependent Claim
58 words
A method as claimed in claim 1 wherein the mixture of medicament and sugar is granulated with a 10 to 20 percent by weight solution of the callulose acetate phthalate in acetone, and the granules are admixed with from about 1/2 to 5 percent by weight magnesium stearate and said mixture is then pressed into substantially void-free tablets.
Claim 5
Dependent Claim
12 words
A method as claimed in claim 5 wherein the sugar is lactose.
Claim 6
Dependent Claim
12 words
A method as clained in claim 5 wherein the sugar is sucrose.
Claim 7
Dependent Claim
128 words
A shaped orally administrable preparation having extended-release characteristics in the gastrointestinal tract comprising a solidly-compacted, substantially void-free body having a hardness of at least 5 kilograms as measured on a hardness tester of U. S. Pharmacopeia specifications, said body being formed in accordance with the process of claim 1 of compressed granules having a size between about 1/2 and 3 mm in diameter and consisting essentially of a medicant, a sugar excipient and 5 to 15 percent by weight of cellulose acetate phthalate, based on the weight of the mixture of medicament and excepient, said body including also between about 1/2 to 10 percent by weight of a calcium or magnesium salt of a higher fatty acid to provide same with a 1 to 12 hour release pattern.
Claim 8
Dependent Claim
11 words
The preparation of claim 8 in the form of a tablet.
Claim 9
Dependent Claim
14 words
The preparation of claim 9 wherein the calcium or magnesium salt is a stearate.
Claim 10
Dependent Claim
11 words
The preparation of claim 10 wherein the medicament is a steroid.
Claim 11
Dependent Claim
10 words
The preparation of claim 11 wherein the steroid is ethisterone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-04-16 | 1976-10-16 | 1977-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-04-16 | 1980-10-16 | 1981-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-04-16 | 1984-10-16 | 1985-04-17 | $7700.00 | Window Closed / Lapsed |