Method of preparing a tablet dosage-form for the immunization of the intestinal tract with live virus preparations
Abstract
Abstract A process for preparing an oral dosage-form suitable for the immunization of the intestinal tract with live virus preparations, which process comprises mixing live virus with a pharmaceutically acceptable excipient, compressing the resulting mixture into a coherent tablet, thereafter compressing a pharmaceutically acceptable excipient about the previously formed tablet in an encasing layer to form a coherent shell having a wall thickness of at least 0.03 inches, and finally completing covering the resulting composite tablet with an enteric coating. The oral dosage-form provided by the method assures the avoidance of undesirable release of live virus in the buccal cavity or the upper intestinal tract, which may result in direct infection in the upper respiratory areas.
Inventors
- 👤 Howard Tint
Bibliographic Details
Claims Analysis
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