Method of treatment using pharmaceutical composition containing dimethyl sulfoxide

Abstract

Abstract THIS INVENTION RELATES TO A METHOD OF ADMINISTERING LIQUID DIMETHYL SULFOXIDE CUTANEOUSLY AND TOPICALLY TO HUMANS AND ANIMALS IN AMOUNTS EFFECTIVE FOR THERAPEUTIC ACTION WITHOUT HAVING THE DIMETHYL SULFOXIDE RUN OFF THE SKIN AND WITHOUT CAUSING SIGNFICANT IRRITATION OF THE SKIN. THE METHOD INVOLVES ADMINISTERING TO THE SURFACE OF THE SKIN AN IONICLY SENSITIVE, SEMI-SOLID GEL OF (I) A MIXTURE OF DIMETHYL SULFOXIDE AND WATER IN THE RATIO FROM ABOUT 50%/50% TO NOT MORE THAN 95%/5% BY WEIGHT, (II) CARBOXY POLYMETHYLENE WATER SOLUBLE RESIN IN AN AMOUNT FROM ABOUT 0.1% TO ABOUT 1.0% BY WEIGHT OF THE GEL COMPOSITION, AND (III) A NEUTRALIZING AGENT SELECTED FROM THE GROUP CONSISTING OF MONOISOPROPANOLAMINE, DIISOPROPANOLAMINE, TRIETHANOLAMINE AND TRIETHYLAMINE IN AN AMOUNT FROM ABOUT 0.01% TO ABOUT 0.3% BY WEIGHT OF THE GEL COMPOSITION, WITH THE LOWER CONCENTRATIONS OF NEUTRALIZING AGENT BEING EMPLOYD WITH THE LOWER CONCENTRATIONS OF RESINS; AND THEN MAINTAINING THE SEMI-SOLID GEL IN CONTACT WITH THE SKIN FOR A PERIOD SUFFICIENT TO ENABLE THE SALT NORMALLY PRESENT AT THE SURFACE OF THE SKIN TO GRADUALLY BREAK THE SEMI-SOLID GEL COMPOSITION AND THEREBY SLOWLY RELAEASE THE LIQUID MIXTURE OF DIMETHYL SULFOXIDE AND WATER OVER THE SURFACE OF THE SKIN WHERE THE SEMISOLID GEL WAS APPLIED.

Inventors

• 👤 Arnold D Marcus
• 👤 Robert E Dempski

Bibliographic Details