Amides and n-hydroxyamides of substituted arylacetic acids and corresponding salts

Abstract

Abstract A NEW GROUP OF AMIDES AND N-HYDROXYAMIDES OF SUBSTITUTED ARYLACETIC ACIDS OF THE FORMULA: (R3,R2,4-(R1-O-)PHENYL)-C(-R4)(-R5)-CO-N(-R6)-R7 WHEREIN: R1 REPRESENTS LINEAR OR BRANCHED ALKYL C1-C8, LINEAR OR BRANCHED ALKENYL C3-C4, LINEAR OR BRANCHED ALKYNYL C3-C4, CYCLOALKYL C5-C6 OR CYCLOALKENYL C5-C6; R4 AND R5 BEING IDENTICAL OR DIFFERENT, REPRESENT HYDROGEN, LINEAR OR BRANCHED ALKYL C1-C4, CYCLOALKYL C5-C6, HYDROXY OR DIALKYLAMINALKYL; R2 AND R3 REPRESENT EITHER BOTH HALOGENS, OR HALOGEN AND HYDROGEN, OR HALOGEN AND ALKYL OR BOTH HYDROGEN BUT, IN THIS CASE, ONLY WHEN ONE OR BOTH R4 AND R5 ARE DIFFERENT FROM HYDROGEN; R6 AND R7 ARE EITHER IDENTICAL OR DIFFERENT MEMBERS OF THE GROUP COMPRISING: HYDROGEN, LINEAR OR BRANCHED ALKYL C1-C4, DIALKYLAMINOALKYLE, HYDROXYALKYLE C1-C4 AND PHENYLALKYLE (ALKYL C1-C4), OR R6 REPRESENTS HYDROXY RADICAL WHILE R7 REPRESENTS HYDROGEN, OR R6 AND R7 FORM TOGETHER WITH THE NITROGEN ATOM A HETEROCYCLIC RING, SAID NEW COMPOUNDS, INCLUDING ALKALI OR ALKALINE-EARTH METAL SALTS AND AMMONIUM SALTS OF N-HYDROXYAMIDES, POSSES A COMBINATION OF ANTIPYRETIC, ANTI-INFLAMMATORY, ANALGESIC AND ANTISPASMODIC PROPERTIES.

Inventors

• 👤 Nguyen Phuc Buu-Hoi
• 👤 Georges Emile Lambelin
• 👤 Claude Leon Gillet
• 👤 Jacques Emile Thiriaux
• 👤 Georges Joseph Mees

Bibliographic Details