US3583230A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sample injection method and apparatus
Assignee: Sondell Research and Development Co
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Filing: 1968-06-12
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Granted: 1971-06-08
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Expires: 1988-06-12
Abstract
Abstract Injector cartridges having filter material are placed in receiving holes around the periphery of a rotating turntable after a sample has been centrifuged into the filter material and the sample is filtered during the centrifuging. The sample within the cartridge is preeluted and then the turntable is rotated sequentially positioning the cartridges beneath an extendable and retractable loader which engages the cartridge. Desired zones of the chromatographic spectrum of the preeluted sample are injected through a capillary outlet in the cartridge into a chromatographic system.
Inventors
- 👤 James A Patterson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:10
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/04; G01N30/24; G01N30/60; G01N30/6091; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
256 words
A sample injector assembly for automatically injecting samples into a chromatographic system comprising: a plurality of sample injector cartridges each having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein, and a capillary outlet opening at the other end of said cartridge communicating with said channel ejecting a sample therethrough; a turntable having a plurality of holes therethrough from one side to the other around the periphery thereof adapted to receive said injector cartridges from one side, and retain said cartridges therein, each said hole including spring biasing means tO bias an injector cartridge inserted therein in the direction of the side of the turntable from which said injector cartridge is inserted; means for rotating said turntable; means stationary relative to said rotating turntable positioned on one side at the periphery thereof comprising an extendable and retractable loader adapted to engage in sealing relationship the inlet opening of an injector cartridge received in a hole in the periphery of the turntable and extend in a direction against the biasing spring means in said hole; a receiving base stationary relative to said rotating turntable positioned on the side of the turntable opposite and in alignment with the extendable and retractable loader, said receiving base having an orifice therein adapted to receive the capillary outlet opening of an injector cartridge in sealing relationship upon engagement of a cartridge by said loader and extension of said loader against a biasing spring means.
Claim 2
Dependent Claim
256 words
A sample injector assembly for automatically injecting samples into a chromatographic system comprising: a plurality of sample injector cartridges each having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein, and a capillary outlet opening at the other end of said cartridge communicating with said channel ejecting a sample therethrough; a turntable having a plurality of holes therethrough from one side to the other around the periphery thereof adapted to receive said injector cartridges from one side, and retain said cartridges therein, each said hole including spring biasing means tO bias an injector cartridge inserted therein in the direction of the side of the turntable from which said injector cartridge is inserted; means for rotating said turntable; means stationary relative to said rotating turntable positioned on one side at the periphery thereof comprising an extendable and retractable loader adapted to engage in sealing relationship the inlet opening of an injector cartridge received in a hole in the periphery of the turntable and extend in a direction against the biasing spring means in said hole; a receiving base stationary relative to said rotating turntable positioned on the side of the turntable opposite and in alignment with the extendable and retractable loader, said receiving base having an orifice therein adapted to receive the capillary outlet opening of an injector cartridge in sealing relationship upon engagement of a cartridge by said loader and extension of said loader against a biasing spring means.
Claim 3
Independent Claim
84 words
A method of preparing a sample and injecting the sample into a chromatographic system comprising: centrifuging the sample into a chromatographic filter material contained in an injector cartridge and filtering the sample during centrifuging of the sample into the injector cartridge; preeluting the sample in the chromatographic filter material in the injector cartridge; positioning the injector cartridge for injecting the sample into a chromatographic system; and injecting desired zones of the chromatographic spectrum of the sample from the injector cartridge into the chromatographic system.
Claim 4
Independent Claim
84 words
A method of preparing a sample and injecting the sample into a chromatographic system comprising: centrifuging the sample into a chromatographic filter material contained in an injector cartridge and filtering the sample during centrifuging of the sample into the injector cartridge; preeluting the sample in the chromatographic filter material in the injector cartridge; positioning the injector cartridge for injecting the sample into a chromatographic system; and injecting desired zones of the chromatographic spectrum of the sample from the injector cartridge into the chromatographic system.
Claim 5
Independent Claim
92 words
A method of preparing a sample and injecting the sample into a chromatographic system comprising: centrifuging the sample through a membrane filter into a chromatographic filter material contained in an injector cartridge; centrifuging a buffer solution through the membrane filter and into the chromatographic filter contained in the injector cartridge; preeluting the sample in the chromatographic filter material in the injector cartridge; positioning the injector cartridge for injecting the sample into a chromatographic system; injecting predetermined zones of the chromatographic spectrum of the sample from the injector cartridge into the chromatographic system.
Claim 6
Independent Claim
92 words
A method of preparing a sample and injecting the sample into a chromatographic system comprising: centrifuging the sample through a membrane filter into a chromatographic filter material contained in an injector cartridge; centrifuging a buffer solution through the membrane filter and into the chromatographic filter contained in the injector cartridge; preeluting the sample in the chromatographic filter material in the injector cartridge; positioning the injector cartridge for injecting the sample into a chromatographic system; injecting predetermined zones of the chromatographic spectrum of the sample from the injector cartridge into the chromatographic system.
Claim 7
Dependent Claim
194 words
A sample injector assembly for automatically injecting samples into a chromatographic system comprising: a fluid line arranged for directing fluid and sample material to said chromatographic system; a plurality of sample injector cartridges, each having a chamber therein, chromatographic filter material located in said chamber, means defining an inlet into said chamber for loading a sample therein, and means defining an outlet from said chamber for ejecting a sample therefrom; table means having a plurality of holes formed therethrough to receive the injector cartridges, each said hole including resilient biasing means to bias an injector cartridge inserted therein in a direction away from the table; said fluid line connected at one end to said chromatographic system and at its other end to a position adjacent said table means; means translating said table means relative to the fluid line for successively positioning said holes in alignment therewith; and means engaging an injector cartridge contained within a hole in the table in alignment wit said fluid line to depress the injector cartridge against the resilient biasing means, thereby to engage the outlet from said injector cartridge and the end of the fluid passageway in sealing relationship.
Claim 8
Dependent Claim
194 words
A sample injector assembly for automatically injecting samples into a chromatographic system comprising: a fluid line arranged for directing fluid and sample material to said chromatographic system; a plurality of sample injector cartridges, each having a chamber therein, chromatographic filter material located in said chamber, means defining an inlet into said chamber for loading a sample therein, and means defining an outlet from said chamber for ejecting a sample therefrom; table means having a plurality of holes formed therethrough to receive the injector cartridges, each said hole including resilient biasing means to bias an injector cartridge inserted therein in a direction away from the table; said fluid line connected at one end to said chromatographic system and at its other end to a position adjacent said table means; means translating said table means relative to the fluid line for successively positioning said holes in alignment therewith; and means engaging an injector cartridge contained within a hole in the table in alignment wit said fluid line to depress the injector cartridge against the resilient biasing means, thereby to engage the outlet from said injector cartridge and the end of the fluid passageway in sealing relationship.
Claim 9
Dependent Claim
99 words
A sample injector for a chromatographic system comprising: an elongated injector cartridge having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein and a capillary outlet opening at the other end of said cartridge communicating with said channel for ejecting a sample therethrough, a membrane filter in the inlet opening end of said cartridge, and at least one screen placed in the iNlet opening end of said injector cartridge to prevent pressure buildup in the injector cartridge on the chromatographic filter material.
Claim 10
Dependent Claim
99 words
A sample injector for a chromatographic system comprising: an elongated injector cartridge having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein and a capillary outlet opening at the other end of said cartridge communicating with said channel for ejecting a sample therethrough, a membrane filter in the inlet opening end of said cartridge, and at least one screen placed in the iNlet opening end of said injector cartridge to prevent pressure buildup in the injector cartridge on the chromatographic filter material.
Claim 11
Dependent Claim
100 words
A sample injector for a chromatographic system comprising: an elongated injector cartridge having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein and a capillary outlet opening at the other end of said cartridge communicating with said channel for ejecting a sample therethrough, said chromatographic filter material comprising a plurality of microspherical cross-linked polymer resin beads, and a tubular support column coaxially mounted within the channel and fine mesh screening fixed at each end of the support column for containing said resin beads.
Claim 12
Dependent Claim
100 words
A sample injector for a chromatographic system comprising: an elongated injector cartridge having a channel therethrough containing a chromatographic filter material, an inlet opening at one end of said cartridge communicating with said channel for loading a sample therein and a capillary outlet opening at the other end of said cartridge communicating with said channel for ejecting a sample therethrough, said chromatographic filter material comprising a plurality of microspherical cross-linked polymer resin beads, and a tubular support column coaxially mounted within the channel and fine mesh screening fixed at each end of the support column for containing said resin beads.
References Cited (Backward Citations)
US3194400A
Cited
US3215500A
Cited
US3201971A
Cited
US3240068A
Cited
US3397965A
Cited
FR1507455A
Cited
US3415627A
Cited
US3444722A
Cited
US3437266A
Cited
US3395093A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-06-07 | 1974-12-07 | 1975-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-06-07 | 1978-12-07 | 1979-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-06-07 | 1982-12-07 | 1983-06-08 | $7700.00 | Window Closed / Lapsed |