US3228841A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic reagent composition for determining blood coagulation factors and method of use
Assignee: Warner Lambert Co LLC
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Filing: 1965-06-10
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Granted: 1966-01-11
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Expires: 1985-06-10
Abstract
No abstract record available.
Inventors
- 👤 Cohen Raphael
- 👤 Jane G Lenahan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:46
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/56
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
135 words
A LYOPHILIZED DIAGNOSTIC COMPOSITION FOR USE IN DETERMINING BLOOD COAGULATION FACTORS COMPRISING A TISSUE THROMBOPLASTIN EXTRACT OF STRONG ACTIVITY, SAID THROMBOPLASTIN BEING PREPARED FROM RABBIT BRAIN TISSUE WHICH HAS BEEN PREVIOUSLY DRIED AND PULVERIZED IN THE PRESENCE OF ACETONE AND COMBINED WITH ABOUT AN EQUAL PART BY WEIGHT OF A FREEZE-DRIED RABBIT LUNG TISSUE, THE COMBINED TISSUES THEN BEING EXTRACTED WITH AN AQUEOUS SOLVENT AT 45 TO 50*C. TO PRODUCE SAID THROMBOPLASTIN EXTRACT; A SOURCE OF CALCIUM ION AT A CONCENTRATION OF ABOUT 0.0125 M; SALT AT A CONCENTRATION OF ABOUT 0.075M; AND PLASMA CONTAINING A HIGH CONCENTRATION OF FACTOR V AND FIBRINOGEN, SAID PLASMA BEING PREPARED BY TREATING PLASMA WITH BARIUM SULFATE TO ABSORB FACTORS VII, IX, X AND PROTHROMBIN, SAID LYOPHILIZED DIAGNOSTIC COMPOSITION BEING BUFFERED AT A PH FROM ABOUT 7.2 TO 7.6.
Claim 2
Dependent Claim
135 words
A LYOPHILIZED DIAGNOSTIC COMPOSITION FOR USE IN DETERMINING BLOOD COAGULATION FACTORS COMPRISING A TISSUE THROMBOPLASTIN EXTRACT OF STRONG ACTIVITY, SAID THROMBOPLASTIN BEING PREPARED FROM RABBIT BRAIN TISSUE WHICH HAS BEEN PREVIOUSLY DRIED AND PULVERIZED IN THE PRESENCE OF ACETONE AND COMBINED WITH ABOUT AN EQUAL PART BY WEIGHT OF A FREEZE-DRIED RABBIT LUNG TISSUE, THE COMBINED TISSUES THEN BEING EXTRACTED WITH AN AQUEOUS SOLVENT AT 45 TO 50*C. TO PRODUCE SAID THROMBOPLASTIN EXTRACT; A SOURCE OF CALCIUM ION AT A CONCENTRATION OF ABOUT 0.0125 M; SALT AT A CONCENTRATION OF ABOUT 0.075M; AND PLASMA CONTAINING A HIGH CONCENTRATION OF FACTOR V AND FIBRINOGEN, SAID PLASMA BEING PREPARED BY TREATING PLASMA WITH BARIUM SULFATE TO ABSORB FACTORS VII, IX, X AND PROTHROMBIN, SAID LYOPHILIZED DIAGNOSTIC COMPOSITION BEING BUFFERED AT A PH FROM ABOUT 7.2 TO 7.6.
References Cited (Backward Citations)
US3179567A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1969-01-10 | 1969-07-12 | 1970-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1973-01-10 | 1973-07-12 | 1974-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1977-01-10 | 1977-07-12 | 1978-01-11 | $7700.00 | Window Closed / Lapsed |