Process of preparing granulation of medicinal agents

Claim 1

IN A METHOD OF PREPARING GRANULATIONS SUITABLE FOR COMPRESSING INTO TABLETS ON AUTOMATIC HIGH SPEED PHARMACEUTICAL TABLETTING MACHINES THE IMPROVEMENT WHICH COMPRISES THE STEPS OF PREPARING A MICROPULVERIZED MIXTURE OF A MEDICAL AGENT AND A SOLID, NON-TOXIC, ORALLY ACCEPTABLE, BINDING AGENT, THE SAID MIXTURE HAVING PARTICLE SIZES WITHIN RANGE 400 TO 80 MESH, PLACING THE MIXED POWDERS IN A TABLE COATING PAN AND ROTATING THE PAN AT SPEEDS WITHIN THE RANGE 5 TO 30 REVOLUTIONS PER MINUTE, WHEREBY THE POWDERED MIXTURE IS CAUSED TO TUMBLE, SPRAYING SURFACE OF THE TUMBLING POWDERS WITH A FINE SPRAY OF SOLVENT FOR SAID BINDING AGENT, THE PARTICLES OF SAID SPRAY BEING LESS THAN 0.2 MM. IN DIAMETER, UNTIL GRANULES ARE FORMED BY ADHESION OF THE TUMBLING SOLID PARTICLES, AND WHEN THE GRANULES HAVE DE VELOPED TO A PARTICLE SIZE WITHIN THE RANGE 200 TO 12 MESH VEDUCING THE RATE OF ROTATION OF THE COATING PAN TO 1 TO 5 REVOLUTIONS PER MINUTE AND DRYING THE GRANULES TO A MOISTURE CONTENT OF 0.4 TO 8 PERCENT BY WEIGHT BY CONTACTING THE SURFACE OF THE SLOWLY TUMBLING GRANULES WITH A STREAM OF HEATED DRY AIR.