Long-acting wax-like talc pillage of penicillin

Claim 1

A PROLONGED ACTION MEDICAL PENICILLIN TABLET COMULES COMPRISED OF A MAJOR AMOUNT OF A WATER-SOLUBLE AGENT HAVING SWELLING PROPERTIES AND A WATER-INSOLUBLE BINDER, SAID GRANULES HAVING BEEN COATED WITH A MIXTURE OF DRY SOLIDS COMPRISING A HYDROPHILIC FIBROUS MATERIAL, A HYDROPHILIC AGENT HAVING SWELLING PROPERTIES AND A SOLID HYDROPHOBIC AGENT SELECTED FROM THE GROUP CONSISTING OF ALKALINE EARTH METAL SALTS OF STEARIC AND PALMITIC ACIDS AND SOLID HYDROGENATED VEGETABLE FATS, AND THE COATED GRANULES HAVING THEN BEEN COMPRESSED, SAID CORE BEING SURROUNDED BY A FIRST BARRIER LAYER OF MIXTURE OF A MAJOR AMOUNT OF TALC WITH READILY WATER-SOLUBLE WAX-LIKE MATERIALS SELECTED FROM THE GROUP CONSISTING OF POLYETHYLENE GLYCOLS HAVING A MOLECULAR WEIGHT OF FROM 1500 TO 6000 AND THE CORRESPONDING MIXED POLYMERS OF ETHYLENE AND PROPYLENE GLYCOLS, AND AN ENTERIC COATING SURROUNDING SAID FIRST BAR RIER LAYER, AND AN OUTER LAYER OF A WATER-SOLUBLE PENICILLIN SALT SEPARATED FROM SAID CORE BY THE BARRIER AND ENTERIC LAYERS DISPOSED BETWEEN THE CORE AND THE OUTER LAYER, SAID PENICILLIN SALT OUTER LAYER CONTAINING APPRECIABLY LESS PENICILLIN THAN SAID CORE AND BEING RELEASED IN THE STOMACH THROUGH THE SOLVENT ACTION OF THE STOMACH JUICES TO CREATE AND ENTERIC LAYERS BEING SOLUBLE AND DISPERSABLE IN THE INTESTINAL FLUIDS WHEREBY SAID CORE IS EXPOSED TO THE ACTION OF THE INTESTINAL FLUIDS AND THERAPEUTIC BLOOD LEVEL OF PENICILLIN IS MAINTAINED BY THE RELEASE IN THE INTESTINES OF THE PENICILLIN IN THE CORE OVER AN EXTENDED PERIOD OF TIME, THE SOLUBLE PENICILLIN SALT BEING PRESENT IN SUBSTANTIALLY THE PROPORTIONS OF AT LEAST ABOUT 400,000 INTERNATIONAL UNITS IN THE CORE TO ABOUT 50,000 TO 200,000 INTERNATIONAL UNITS IN THE OUTER LAYER.