US2875130A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing sustained release particles and the product of the method
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1956-11-20
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Granted: 1959-02-24
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Expires: 1976-11-20
Abstract
No abstract record available.
Inventors
- 👤 Jr George M Grass
- 👤 Manford J Robinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
235 words
THE METHOD OF PREPARING A SUSTANED RELEASE PHARMACEUTICAL POWDER WHICH COMPRISES REDUCING A SOLID MEDICAMENT TO A PARTICLE SIZE OF A MAXIMUM OF ABOUT 10 MICRONS, MIXING THE THUS FORMED PARTICLES IN FROM ABOUT 5% TO ABOUT 35% BY WEIGHT OF A LIQUEFIED LIPID MATERIAL WHICH IS SUBSTANITALLY WATER INSOLUBLE AND HAS A MELTING POINT OF ABOVE 85*C., SOLUBLE AND HAD THUS FORMED A PRIMARY POWDER HAVING A MAXIMUM PARTURE TO FORM A PRIMARY POWDERHAVING A MIXIMUM PARTICLE SIZE IN THE RANGE OF FROM ABOUT 5 TO 25 MICRONS MIXING THE THUS FORMED POWDER WITH A MELT OF FORM ABOUT 25% TO ABOUT 85% BY WEIGHT OF A LIPID MATERIAL WHICH IS SUBSTANTIALLY WATER INSSOLIDIFIED MIXPOINT WHICH IS A MINIMUM OF ABOUT 5*C, LOWER THAN THE MELTING POINT OF THE FIRST MENTIONED LIPID MATERIAL MAINTAINING THE TEMPERATURE OF THE MATERIAL AND ABOVE ING POINT OF THE FIRST MENTIONED LIPID MATERIAL AND ABOVE THE MELTING POINT OF THE SECOND MENTIONED LIPID MATERIAL, MIXING THE POWDER-LIPID MIXTURE WITH WATER TO FORM AN EMULSION WHILE MAINTAINING THE WATER-POWER-LIPID MIXTURE AT A TEMPERATURE ABOVE THE MELTING POINT OF MENTIONED LIPID MATERIAL AND BELOW THE MELTING POINT OF THE FIRST MENTIONED LIPID MATERIAL, COOLING THE EMULSION TO A TEMPERATURE BELOW THE MELTING POINT OF THE SECOND MENTIONED LIPID MATERIAL TO PRECIPITATE THE SUSTAINED RELEASE PHARMACEUTICAL POWDER, SAID SOLID MEDICAMENT HAVING A MELTING POINT HIGHER THAN THE SECOND MENTIONED LIPID MATERIAL.
Claim 2
Independent Claim
235 words
THE METHOD OF PREPARING A SUSTANED RELEASE PHARMACEUTICAL POWDER WHICH COMPRISES REDUCING A SOLID MEDICAMENT TO A PARTICLE SIZE OF A MAXIMUM OF ABOUT 10 MICRONS, MIXING THE THUS FORMED PARTICLES IN FROM ABOUT 5% TO ABOUT 35% BY WEIGHT OF A LIQUEFIED LIPID MATERIAL WHICH IS SUBSTANITALLY WATER INSOLUBLE AND HAS A MELTING POINT OF ABOVE 85*C., SOLUBLE AND HAD THUS FORMED A PRIMARY POWDER HAVING A MAXIMUM PARTURE TO FORM A PRIMARY POWDERHAVING A MIXIMUM PARTICLE SIZE IN THE RANGE OF FROM ABOUT 5 TO 25 MICRONS MIXING THE THUS FORMED POWDER WITH A MELT OF FORM ABOUT 25% TO ABOUT 85% BY WEIGHT OF A LIPID MATERIAL WHICH IS SUBSTANTIALLY WATER INSSOLIDIFIED MIXPOINT WHICH IS A MINIMUM OF ABOUT 5*C, LOWER THAN THE MELTING POINT OF THE FIRST MENTIONED LIPID MATERIAL MAINTAINING THE TEMPERATURE OF THE MATERIAL AND ABOVE ING POINT OF THE FIRST MENTIONED LIPID MATERIAL AND ABOVE THE MELTING POINT OF THE SECOND MENTIONED LIPID MATERIAL, MIXING THE POWDER-LIPID MIXTURE WITH WATER TO FORM AN EMULSION WHILE MAINTAINING THE WATER-POWER-LIPID MIXTURE AT A TEMPERATURE ABOVE THE MELTING POINT OF MENTIONED LIPID MATERIAL AND BELOW THE MELTING POINT OF THE FIRST MENTIONED LIPID MATERIAL, COOLING THE EMULSION TO A TEMPERATURE BELOW THE MELTING POINT OF THE SECOND MENTIONED LIPID MATERIAL TO PRECIPITATE THE SUSTAINED RELEASE PHARMACEUTICAL POWDER, SAID SOLID MEDICAMENT HAVING A MELTING POINT HIGHER THAN THE SECOND MENTIONED LIPID MATERIAL.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1962-02-23 | 1962-08-25 | 1963-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1966-02-23 | 1966-08-25 | 1967-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1970-02-23 | 1970-08-25 | 1971-02-24 | $7700.00 | Window Closed / Lapsed |