US2761810A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of blood fraction for use in rh testing procedures
Assignee: Ortho Pharmaceutical Corp
•
Filing: 1954-07-22
•
Granted: 1956-09-04
•
Expires: 1974-07-22
Abstract
No abstract record available.
Inventors
- 👤 Heron O Singher
- 👤 Alfred B Kupferberg
- 👤 Richard S Lowy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:56
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/80; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
207 words
THE PROCESS OF PREPARING BLOOD SERUM PROTEINS SUITABLE FOR USE IN DEMONSTRATING INCOMPLETE RH ANTIBODIES BY SUSPENDING REACTING BLOOD CELLS IN A SOLUTION OF THE BLOOD SERUM PROTEINS WHICH COMPRISES: ADDING TO MAMMALIAN BLOOD SERUM AN ALKALI METAL SALT OF AN ORGANIC ACID SELECTED FROM THE GROUP CONSISTING OF FATTY ACIDS HAVING FROM 4 TO 10 CARBON ATOMS AND ACETYLTRYPTOPHANE IN AN AMOUNT SUFFICIENT TO BRING THE MOLARITY OF THE SERUM WITH RESPECT THERETO TO WITHIN THE RANGE OF 0.13-0.17; ADJUSTING THE PH OF THE SOLUTION TO 6.8-8.2; HEATING THE SOLUTION; COOLING THE SOLUTION; ADJUSTING THE PH OF THE SOLUTION TO 5.55-5.60, WHEREBY A PRECIPITATE OF DENATURED GLOBULINS IS FORMED; REMOVING THE PRECIPITATED DENATURED GLOBULINS FROM THE SOLUTION; ADJUSTING THE PH OF THE SOLUTION TO 3.0-5.5, WHEREBY ALPHA-GLOBULINS ARE PRECIPITATED; COOLING THE SOLUTION TO A TEMPERATURE NOT SUBSTANTIALLY ABOVE 5* C.; ADDING A LOW TEMPERATURE NOT SUBSTANTIALLY ALCOHOL TO THE SOLUTION IN AN AMOUNT SUFFICIENT TO BRING THE CONCENTRATION OF ALCOHOL IN THE SOLUTION TO AT LEAST 10 MOLS PER LITER AND AT SUCH A RATE THAT THE TEMPERATURE OF THE SOLUTION DOES NOT RISE ABOVE 5* C. DURING THE COURTSE OF THE ADDITION, WHEREBY ALBUMIN IS PRECIPITATED; AND REMOVING PRECIPITATED ALPHA-GLOBULINS AND ALBUMIN FROM THE SOLUTION.
Claim 2
Dependent Claim
207 words
THE PROCESS OF PREPARING BLOOD SERUM PROTEINS SUITABLE FOR USE IN DEMONSTRATING INCOMPLETE RH ANTIBODIES BY SUSPENDING REACTING BLOOD CELLS IN A SOLUTION OF THE BLOOD SERUM PROTEINS WHICH COMPRISES: ADDING TO MAMMALIAN BLOOD SERUM AN ALKALI METAL SALT OF AN ORGANIC ACID SELECTED FROM THE GROUP CONSISTING OF FATTY ACIDS HAVING FROM 4 TO 10 CARBON ATOMS AND ACETYLTRYPTOPHANE IN AN AMOUNT SUFFICIENT TO BRING THE MOLARITY OF THE SERUM WITH RESPECT THERETO TO WITHIN THE RANGE OF 0.13-0.17; ADJUSTING THE PH OF THE SOLUTION TO 6.8-8.2; HEATING THE SOLUTION; COOLING THE SOLUTION; ADJUSTING THE PH OF THE SOLUTION TO 5.55-5.60, WHEREBY A PRECIPITATE OF DENATURED GLOBULINS IS FORMED; REMOVING THE PRECIPITATED DENATURED GLOBULINS FROM THE SOLUTION; ADJUSTING THE PH OF THE SOLUTION TO 3.0-5.5, WHEREBY ALPHA-GLOBULINS ARE PRECIPITATED; COOLING THE SOLUTION TO A TEMPERATURE NOT SUBSTANTIALLY ABOVE 5* C.; ADDING A LOW TEMPERATURE NOT SUBSTANTIALLY ALCOHOL TO THE SOLUTION IN AN AMOUNT SUFFICIENT TO BRING THE CONCENTRATION OF ALCOHOL IN THE SOLUTION TO AT LEAST 10 MOLS PER LITER AND AT SUCH A RATE THAT THE TEMPERATURE OF THE SOLUTION DOES NOT RISE ABOVE 5* C. DURING THE COURTSE OF THE ADDITION, WHEREBY ALBUMIN IS PRECIPITATED; AND REMOVING PRECIPITATED ALPHA-GLOBULINS AND ALBUMIN FROM THE SOLUTION.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1959-09-04 | 1960-03-05 | 1960-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1963-09-04 | 1964-03-05 | 1964-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1967-09-04 | 1968-03-05 | 1968-09-04 | $7700.00 | Window Closed / Lapsed |