Patent WO1984001706A1 successfully refreshed from Google Patents.
US20070225747A1
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US
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Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction
Assignee: Pulmonx Corp
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Filing: 2007-03-07
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Granted: —
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Expires: 2027-03-07
Abstract
Abstract Lung conditions are treated by implanting a flow restrictor in a passageway upstream from a diseased lung segment. The restrictor will create an orifice at the implantation site which inhibits air exchange with the segment to induce controlled atelectasis and/or hypoxia. Controlled atelectasis can induce collapse of the diseased segment with a reduced risk of pneumothorax. Hypoxia can promote gas exchange with non-isolated, healthy regions of the lung even in the absence of lung collapse.
Inventors
- 👤 Rodney C. Perkins
- 👤 Nikolai Aljuri
- 👤 Ajit Nair
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:46
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12099; A61B17/12104; A61F2/95; A61F2002/043; A61F2/06; A61F2002/068
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
62 words
1 . A method for treating a lung condition, said method comprising: implanting an air flow restrictor in an airway of the lung, wherein said restrictor reduces air flow exchange between upstream of the restrictor and downstream of the restrictor, wherein such air flow restriction induces at least one of controlled atelectasis and localized hypoxia in a treated region beyond the restriction.
Claim 2
Dependent Claim
62 words
1 . A method for treating a lung condition, said method comprising: implanting an air flow restrictor in an airway of the lung, wherein said restrictor reduces air flow exchange between upstream of the restrictor and downstream of the restrictor, wherein such air flow restriction induces at least one of controlled atelectasis and localized hypoxia in a treated region beyond the restriction.
Claim 3
Dependent Claim
27 words
2 . A method as in claim 1 , wherein controlled atelectasis is induced which causes collapse of the treated region downstream of the air flow restrictor.
Claim 4
Dependent Claim
26 words
3 . A method as in claim 2 , wherein the treated region collapses over a period in the range from 12 hours to 30 days.
Claim 5
Dependent Claim
37 words
4 . A method as in claim 1 , wherein localized hypoxia is induced without collapse of the treated region, wherein the hypoxia shifts blood flow away from the treated region to other regions of the lung.
Claim 6
Dependent Claim
29 words
5 . A method as in claim 4 , wherein the treated region has collateral flow channels with adjacent lung regions, wherein collateral flow channels inhibit atelectasis and collapse.
Claim 7
Dependent Claim
37 words
6 . A method as in claim 1 , wherein the volumetric rate of the restricted air flow exchange is reduced by a percentage from 10% to 99.99% of the unrestricted volumetric rate of air flow exchange.
Claim 8
Dependent Claim
17 words
7 . A method as in claim 6 , wherein the percentage is from 99% to 99.9%.
Claim 9
Dependent Claim
23 words
8 . A method as in claim 1 , wherein the restrictor includes at least one open passage which permits air flow exchange.
Claim 10
Dependent Claim
17 words
9 . A method as in claim 8 , wherein the passage consists of a single orifice.
Claim 11
Dependent Claim
17 words
10 . A method as in claim 8 , wherein the restrictor includes a plurality of passages.
Claim 12
Dependent Claim
33 words
11 . A method as in claim 8 , wherein the open passage area is in the range from 0.01% to 90% of the area of the airway where the restrictor is implanted.
Claim 13
Dependent Claim
27 words
12 . A method as in claim 8 , wherein the open passage area is in the range from 0.01 mm 2 to 50 mm 2 .
Claim 14
Dependent Claim
29 words
13 . A method as in claim 1 , wherein implanting comprises releasing a self-expanding restrictor from a constraint so that the restrictor opens and anchors in the airway.
Claim 15
Dependent Claim
18 words
14 . A method as in claim 13 , wherein the restrictor is released from a tubular introducer.
Claim 16
Dependent Claim
18 words
15 . A method as in claim 1 , wherein the restrictor is expanded by an expansion member.
Claim 17
Dependent Claim
48 words
16 . A bronchial flow restrictor comprising a body having at least one open passage to permit bidirectional air flow therethrough, wherein the body is adapted to be expanded and anchored within a lung airway for the control of air exchange with a downstream region of the lung.
Claim 18
Dependent Claim
48 words
16 . A bronchial flow restrictor comprising a body having at least one open passage to permit bidirectional air flow therethrough, wherein the body is adapted to be expanded and anchored within a lung airway for the control of air exchange with a downstream region of the lung.
Claim 19
Dependent Claim
19 words
17 . A bronchial flow restrictor as in claim 16 , wherein the passage consists of a single orifice.
Claim 20
Dependent Claim
19 words
18 . A bronchial flow restrictor as in claim 16 , wherein the restrictor includes a plurality of passages.
Claim 21
Dependent Claim
33 words
19 . A bronchial flow restrictor as in claim 16 , wherein the open passage area is in the range from 0.01% to 90% of the cross-sectional area of the body when expanded.
Claim 22
Dependent Claim
29 words
20 . A bronchial flow restrictor as in claim 16 , wherein the open passage area is in the range from 0.01 mm 2 to 50 mm 2 .
Claim 23
Dependent Claim
28 words
21 . A bronchial flow restrictor as in claim 5 , wherein the at least one passage comprises a plurality of channels on the outside of the body.
Claim 24
Dependent Claim
42 words
22 . A bronchial flow restrictor as in claim 16 , wherein the body is elastic so that it can be constrained to a smaller width for introduction to the lung airway and released to self-expand and anchor at a designated location.
Claim 25
Dependent Claim
21 words
23 . A bronchial flow restrictor as in claim 16 , is malleable and expandable by application of an expansion force.
Claim 26
Dependent Claim
53 words
24 . A bronchial flow restrictor as in claim 16 , wherein the body comprises a plurality of woven elements adapted to radially self-expand and form a generally contiguous surface having a plurality of openings which provide a resistance to the bi-directional flow of air when deployed in an airway of a lung.
Claim 27
Dependent Claim
31 words
25 . A system comprising a bronchial flow restrictor as in claim 1 , and a delivery catheter adapted to deliver the bronchial flow restrictor in an airway of the lung.
Claim 28
Dependent Claim
57 words
26 . A system as in claim 25 , wherein the delivery catheter comprises an outer catheter tube and an inner pusher member, wherein the bronchial flow restrictor is receivable in a distal end of the outer catheter tube and the inner pusher member is adapted to advance and release the bronchial flow restrictor from the tube.
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