US20050177068A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Debulking catheters and methods
Assignee: Covidien LP
•
Filing: 2004-07-21
•
Granted: —
•
Expires: 2024-07-21
Abstract
Abstract A debulking catheter comprising a tissue debulking assembly for removing a contiguous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking assembly is radially movable to expose at least a portion of the assembly through a window on the catheter body. The catheter is advanced transluminally through the body lumen to contact material in the body lumen and remove a plane of contiguous material that has a length that is typically longer than a length of the window on the catheter. The contiguous material may be directed into a collection chamber. Thereafter, the material may be removed from the collection chamber and preserved or tested.
Inventors
- 👤 John Simpson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:42
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/32; A61B17/3205; A61B17/3207; A61B17/320758; A61B17/320783; A61B2017/00681; A61B2017/00685; A61B17/28; A61B17/29; A61B2017/2926; A61B2017/2927; A61B17/320016; A61B17/32002; A61B2017/320032
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
178 words
1 . A method of excising and testing material from a body lumen, the method comprising: providing a catheter having a rotating cutter, a collection chamber, and a cutting window, the rotating cutter being movable between a stored position and an exposed position, at least part of the rotating cutter becoming exposed through the cutting window when moving to the exposed position; exposing the cutter by moving the cutter to the exposed position; advancing the catheter to move the rotating cutter through material in a first site in the body lumen, the rotating cutter remaining in the exposed position so that the cutter and the window maintain their orientation with respect to one another when advancing the catheter through the material, the material cut by the rotating cutter comprising a contiguous strand and being directed through the cutting window and into the collection chamber as the catheter is advanced through the material; removing the material from the collection chamber; and performing one or more tests on at least a portion of the material removed from the collection chamber.
Claim 2
Dependent Claim
178 words
1 . A method of excising and testing material from a body lumen, the method comprising: providing a catheter having a rotating cutter, a collection chamber, and a cutting window, the rotating cutter being movable between a stored position and an exposed position, at least part of the rotating cutter becoming exposed through the cutting window when moving to the exposed position; exposing the cutter by moving the cutter to the exposed position; advancing the catheter to move the rotating cutter through material in a first site in the body lumen, the rotating cutter remaining in the exposed position so that the cutter and the window maintain their orientation with respect to one another when advancing the catheter through the material, the material cut by the rotating cutter comprising a contiguous strand and being directed through the cutting window and into the collection chamber as the catheter is advanced through the material; removing the material from the collection chamber; and performing one or more tests on at least a portion of the material removed from the collection chamber.
Claim 3
Dependent Claim
24 words
2 . The method of claim 1 comprising placing the material in a preserving agent, tissue fixative, or a preparation agent prior to testing.
Claim 4
Dependent Claim
37 words
3 . The method of claim 2 , wherein the preserving agent, tissue fixative, or preparing agent comprises saline, heparinized saline, liquid nitrogen, formalin, a membrane lysis agent, a RNA preparation agent, or a DNA preparation agent.
Claim 5
Dependent Claim
67 words
4 . The method of claim 1 , wherein the tests comprise genomic screening, DNA hybridization, RNA hybridization, gene expression analysis, PCR amplification, proteomic testing, drug efficacy screening, determining the presence of one or more DNA markers, determining the presence of one or more RNA markers, determining the presence of one or more protein markers, histological testing, histopathology, cytopathology, cell type analysis, tissue type analysis, or biopsy.
Claim 6
Dependent Claim
95 words
5 . The method of claim 1 , wherein performing one or more tests comprises analyzing the material for the presence of DNA RNA, or a protein marker comprising a smooth muscle proliferative promoter, a smooth muscle proliferative inhibitor, a cellular marker, an apoptotic marker, a cell cycle protein, a transcriptional factor, a proliferative marker, an endothelial growth factor, an adhesion molecule, a cytokine, a chemokine, a chemokine receptor, an inflammation marker, an extracellular matrix molecule, an interleukin, a growth factor, a glycoprotein, a proteoglycan, a cell-surface marker, a serum marker, or an immune factor.
Claim 7
Dependent Claim
117 words
6 . The method of claim 1 , wherein prior to removing the material form the collection chamber the method further comprises: moving the cutter to the stored position; repositioning the catheter at a second site; exposing the cutter by moving the cutter to the exposed position; advancing the catheter to move the rotating cutter through material in the second site, the rotating cutter remaining in the exposed position so that the cutter and the window maintain their orientation with respect to one another when advancing the catheter through the material, the material cut by the rotating cutter being directed through the cutting window and into the collection chamber as the catheter is advanced through the material.
Claim 8
Dependent Claim
22 words
7 . The method of claim 6 , wherein the first site and the second site are in the same body lumen.
Claim 9
Dependent Claim
21 words
8 . The method of claim 6 , wherein the first site and the second site are in different body lumens.
Claim 10
Dependent Claim
51 words
9 . The method of claim 1 , wherein advancing the catheter to move the rotating cutter through the material excises at least one contiguous strand of material from the inner surface of the body lumen, wherein the contiguous strands comprise from about 1 mg to about 2000 mg of material.
Claim 11
Dependent Claim
46 words
10 . The method of claim 1 , wherein advancing the catheter moves the cutter through the material excises at least one contiguous strand of material from the body lumen, wherein the length of the strands is longer than a largest dimension of the cutting window.
Claim 12
Dependent Claim
98 words
11 . The method of claim 9 , wherein the contiguous strands comprise from about 1 mg to about 100 mg of material, from about 100 to about 200 mg of material, from about 200 mg to about 300 mg of material, from about 300 to about 400 mg of material, from about 400 to about 500 mg of material, from about 500 to about 600 mg of material, from about 600 to about 700 mg of material, from about 700 to about 800 mg of material, or from about 800 mg to about 2000 mg of material.
Claim 13
Dependent Claim
14 words
12 . The method of claim 1 , wherein the material comprises plaque tissue.
Claim 14
Dependent Claim
199 words
13 . A method for excising and testing material from a vascular location, comprising the steps of: providing a catheter having a body, an opening leading to a collection chamber, and a rotatable cutter, the cutter being movable between a stored position and an exposed position, the cutter becoming at least partially exposed when moving from the stored position to the exposed position; introducing the catheter into a patient's vascular system with the cutter in the stored position, the catheter being introduced to the vascular location where material is to be excised; exposing the cutter by moving the cutter to the exposed position; rotating the cutter; advancing the catheter after the exposing step and the rotating step, wherein the rotating cutter and the opening advance together so that material cut by the rotating cutter is directed through the opening and into the collection chamber as the catheter is advanced; removing the catheter from the vascular location; harvesting the material from the collection chamber after the catheter has been removed from the vascular location and the vascular system of the patient; and performing one or more tests on at least a portion of the material removed from the collection chamber.
Claim 15
Dependent Claim
199 words
13 . A method for excising and testing material from a vascular location, comprising the steps of: providing a catheter having a body, an opening leading to a collection chamber, and a rotatable cutter, the cutter being movable between a stored position and an exposed position, the cutter becoming at least partially exposed when moving from the stored position to the exposed position; introducing the catheter into a patient's vascular system with the cutter in the stored position, the catheter being introduced to the vascular location where material is to be excised; exposing the cutter by moving the cutter to the exposed position; rotating the cutter; advancing the catheter after the exposing step and the rotating step, wherein the rotating cutter and the opening advance together so that material cut by the rotating cutter is directed through the opening and into the collection chamber as the catheter is advanced; removing the catheter from the vascular location; harvesting the material from the collection chamber after the catheter has been removed from the vascular location and the vascular system of the patient; and performing one or more tests on at least a portion of the material removed from the collection chamber.
Claim 16
Dependent Claim
24 words
14 . The method of claim 13 comprising placing the material in a preserving agent, tissue fixative, or a preparation agent prior to testing.
Claim 17
Dependent Claim
37 words
15 . The method of claim 14 , wherein the preserving agent, tissue fixative, or preparing agent comprises saline, heparinized saline, liquid nitrogen, formalin, a membrane lysis agent, a RNA preparation agent, or a DNA preparation agent.
Claim 18
Dependent Claim
67 words
16 . The method of claim 13 , wherein the tests comprise genomic screening, DNA hybridization, RNA hybridization, gene expression analysis, PCR amplification, proteomic testing, drug efficacy screening, determining the presence of one or more DNA markers, determining the presence of one or more RNA markers, determining the presence of one or more protein markers, histological testing, histopathology, cytopathology, cell type analysis, tissue type analysis, or biopsy.
Claim 19
Dependent Claim
95 words
17 . The method of claim 13 , wherein performing one or more tests comprises analyzing the material for the presence of DNA RNA, or a protein marker comprising a smooth muscle proliferative promoter, a smooth muscle proliferative inhibitor, a cellular marker, an apoptotic marker, a cell cycle protein, a transcriptional factor, a proliferative marker, an endothelial growth factor, an adhesion molecule, a cytokine, a chemokine, a chemokine receptor, an inflammation marker, an extracellular matrix molecule, an interleukin, a growth factor, a glycoprotein, a proteoglycan, a cell-surface marker, a serum marker, or an immune factor.
Claim 20
Dependent Claim
117 words
18 . The method of claim 1 , wherein prior to removing the material form the collection chamber the method further comprises: moving the cutter to the stored position; repositioning the catheter at a second site; exposing the cutter by moving the cutter to the exposed position; advancing the catheter to move the rotating cutter through material in the second site, the rotating cutter remaining in the exposed position so that the cutter and the window maintain their orientation with respect to one another when advancing the catheter through the material, the material cut by the rotating cutter being directed through the cutting window and into the collection chamber as the catheter is advanced through the material.
Claim 21
Dependent Claim
22 words
19 . The method of claim 18 , wherein the first site and the second site are in the same body lumen.
Claim 22
Dependent Claim
21 words
20 . The method of claim 18 , wherein the first site and the second site are in different body lumens.
Claim 23
Dependent Claim
51 words
21 . The method of claim 13 , wherein advancing the catheter to move the rotating cutter through the material excises at least one contiguous strand of material from the inner surface of the body lumen, wherein the contiguous strands comprise from about 1 mg to about 2000 mg of material.
Claim 24
Dependent Claim
46 words
22 . The method of claim 13 , wherein advancing the catheter moves the cutter through the material excises at least one contiguous strand of material from the body lumen, wherein the length of the strands is longer than a largest dimension of the cutting window.
Claim 25
Dependent Claim
98 words
23 . The method of claim 21 , wherein the contiguous strands comprise from about 1 mg to about 100 mg of material, from about 100 to about 200 mg of material, from about 200 mg to about 300 mg of material, from about 300 to about 400 mg of material, from about 400 to about 500 mg of material, from about 500 to about 600 mg of material, from about 600 to about 700 mg of material, from about 700 to about 800 mg of material, or from about 800 mg to about 2000 mg of material.
Claim 26
Dependent Claim
14 words
24 . The method of claim 13 , wherein the material comprises plaque tissue.
Claim 27
Dependent Claim
27 words
25 . A lumenectomy material composition comprising at least one contiguous tissue strand collected in vivo from an inner surface of a body lumen of a subject.
Claim 28
Dependent Claim
27 words
25 . A lumenectomy material composition comprising at least one contiguous tissue strand collected in vivo from an inner surface of a body lumen of a subject.
Claim 29
Dependent Claim
15 words
26 . The composition of claim 25 , wherein the body lumen is an artery.
Claim 30
Dependent Claim
15 words
27 . The composition of claim 26 , wherein the tissue strand comprises arterial plaque.
Claim 31
Dependent Claim
20 words
28 . The composition of claim 25 further comprising a preserving agent, a tissue fixative, or a test preparation agent.
Claim 32
Dependent Claim
37 words
29 . The composition of claim 28 , wherein the preserving agent, tissue fixative or preparation agent comprises saline, heparinized saline, liquid nitrogen, formalin, a membrane lysis agent, a RNA preparation agent, or a DNA preparation agent.
Claim 33
Dependent Claim
29 words
30 . The composition of claim 25 , wherein the material comprises a plurality of contiguous tissue strands collected from a location in a blood vessel of the subject.
Claim 34
Dependent Claim
19 words
31 . The composition of claim 30 , wherein the location is in a single vessel of the subject.
Claim 35
Dependent Claim
30 words
32 . The composition of claim 30 , wherein the location is a first location in a first vessel and a second location in the same vessel of the subject.
Claim 36
Dependent Claim
30 words
33 . The composition of claim 30 , wherein the location is a first location in a first vessel and a second location in a different vessel of the subject.
Claim 37
Dependent Claim
91 words
34 . The composition of claim 25 , wherein the amount of material collected from the subject is an amount sufficient to successfully perform one or more tests comprising genomic screening, DNA hybridization, RNA hybridization, gene expression analysis, PCR amplification, proteomic testing, drug efficacy screening, a determination of the presence of one or more protein markers, a determination of the presence of one or more DNA markers, a determination of the presence of one or more RNA markers, histological testing, histopathology testing, cytopathology, cell type analysis, tissue type analysis, or biopsy.
Claim 38
Dependent Claim
19 words
35 . The composition of claim 34 , wherein the amount of material collected is greater than 1 mg.
Claim 39
Dependent Claim
23 words
36 . The composition of claim 35 , wherein the amount of material collected is from about 1 mg to about 2000 mg.
Claim 40
Dependent Claim
88 words
37 . The composition of claim 36 , wherein the amount of material collected is from about 1 mg to about 100 mg, from about 100 mg to about 200 mg, from about 200 mg to about 300 mg, from about 300 mg to about 400 mg, from about 400 mg to about 500 mg, from about 500 mg to about 600 mg, from about 600 mg to about 700 mg, from about 700 mg to about 800 mg, or from about 800 mg to about 2000 mg.
Claim 41
Dependent Claim
41 words
38 . A method of diagnosing a condition of a patient comprising performing one or more diagnostic test on the composition of claim 25; and proposing a therapeutic protocol based on information derived from one or more of the diagnostic tests.
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