US20020055143A1
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Bone precursor compositions
Assignee: TEL BIOSCIENCES Inc
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Filing: 2001-05-29
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Granted: —
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Expires: 2021-05-29
Abstract
Abstract Bone precursor compositions, methods of preparation and use are described. Bone precursor compositions include a calcium cement which is suitable for injection, wherein the calcium cement includes monobasic calcium phosphate monohydrate and beta-tricalcium phosphate. The bone precursor compositions can further include biopolymer foams, collagen, extracellular matrix components, therapeutic agents, or biopolymer fibers. The bone precursor compositions can also include or be conditioned with cells, such as connective tissue cells, preferably bone tissue cells.
Inventors
- 👤 Eugene Bell
- 👤 Tracy Sioussat
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/3843; A61L27/3847; A61L27/02; A61L27/12; A61L27/3604; A61L27/3633; A61L27/3641; A61L27/3645; A61L27/3804; A61L27/40; A61L27/44; A61L27/46; A61L2400/00; A61L2400/06; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 61
Claim 1
Independent Claim
27 words
1 . A bone precursor composition, comprising a calcium cement which is suitable for injection, wherein the calcium cement includes monobasic calcium phosphate monohydrate and beta-tricalcium phosphate.
Claim 2
Dependent Claim
27 words
1 . A bone precursor composition, comprising a calcium cement which is suitable for injection, wherein the calcium cement includes monobasic calcium phosphate monohydrate and beta-tricalcium phosphate.
Claim 3
Dependent Claim
16 words
2 . The composition of claim 1 , further comprising calcium pyrophosphate and alpha-calcium sulfate hemihydrate.
Claim 4
Dependent Claim
25 words
3 . The composition of claim 2 , wherein the ratio by weight of monobasic calcium phosphate monohydrate to beta-tricalcium phosphate is 1:2 to 1:3.75.
Claim 5
Dependent Claim
29 words
4 . The composition of claim 1 , wherein the calcium cement is in the form of granules with a diameter of between about 1 to 500 μm inclusive.
Claim 6
Dependent Claim
15 words
5 . The composition of claim 4 , which includes or is conditioned with cells.
Claim 7
Dependent Claim
17 words
6 . The composition of claim 5 , wherein the cells are tissue cells or mesenchymal cells.
Claim 8
Dependent Claim
19 words
7 . The composition of claim 6 , wherein the mesenchymal cells are connective tissue cells or bone cells.
Claim 9
Dependent Claim
27 words
8 . The composition of claim 7 , wherein the connective tissue cells are selected from the group consisting of ligament cells and chondrocytes and tendon cells.
Claim 10
Dependent Claim
27 words
9 . The composition of claim 7 , wherein the bone cells are selected from the group consisting of bone marrow stem cells, osteocytes, osteoblasts and osteoclasts.
Claim 11
Dependent Claim
13 words
10 . The composition of claim 1 , further comprising an injection vehicle.
Claim 12
Dependent Claim
25 words
11 . The composition of claim 10 , wherein the injection vehicle is selected from the group consisting of microfibrillar collagen and unassembled liquid collagen.
Claim 13
Dependent Claim
27 words
12 . The composition of claim 11 , wherein said injection vehicle is unassembled liquid collagen in a concentration from about 0.5 mg/ml to about 40 mg/ml.
Claim 14
Dependent Claim
26 words
13 . The composition of claim 10 , wherein said injection vehicle further comprises collagen foam, collagen fiber particles, methyl cellulose, or a pharmaceutically acceptable vehicle.
Claim 15
Dependent Claim
27 words
14 . The composition of claim 10 , wherein said calcium cement comprises calcium pyrophosphate, alpha calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate and beta tricalcium phosphate.
Claim 16
Dependent Claim
51 words
15 . The composition of claim 2 , wherein said calcium cement comprises, by weight, between about 1 and 5 percent calcium pyrophosphate, between about 5 and 15 percent alpha-calcium sulfate hemihydrate, between about 5 and 25 percent monobasic calcium phosphate monohydrate and between about 55 and 75 percent beta-tricalcium phosphate.
Claim 17
Dependent Claim
15 words
16 . The composition of claim 1 , further comprising a therapeutic or analgesic agent.
Claim 18
Dependent Claim
15 words
17 . The composition of claim 11 , wherein the collagen is fetal porcine collagen.
Claim 19
Dependent Claim
20 words
18 . The composition of claim 1 , further comprising macromolecules necessary for cell growth, morphogenesis, differentiation and tissue building.
Claim 20
Dependent Claim
19 words
19 . The composition of claim 18 , wherein the macromolecules are in the form of extracellular matrix particulates.
Claim 21
Dependent Claim
26 words
20 . The composition of claim 19 , wherein the extracellular matrix particulates comprise between about 0.05 to 20 weight percent of the composition when dry.
Claim 22
Dependent Claim
12 words
21 . The composition of claim 1 , further comprising pore-generating particles.
Claim 23
Dependent Claim
26 words
22 . The composition of claim 21 , wherein said pore-generating particles are selected from the group consisting of gelatin and calcium sulfate, or mixtures thereof
Claim 24
Dependent Claim
14 words
23 . A bone precursor composite, comprising a calcium cement; and a biopolymer structure.
Claim 25
Dependent Claim
14 words
23 . A bone precursor composite, comprising a calcium cement; and a biopolymer structure.
Claim 26
Dependent Claim
14 words
24 . The composite of claim 23 , wherein said biopolymer structure is collagen.
Claim 27
Dependent Claim
15 words
25 . The composite of claim 24 , wherein the collagen is fetal porcine collagen.
Claim 28
Dependent Claim
19 words
26 . The composite of claim 23 wherein the biopolymer structure is a sponge or a single density foam.
Claim 29
Dependent Claim
16 words
27 . The composite of claim 23 wherein the biopolymer structure is a fiber or fibers.
Claim 30
Dependent Claim
14 words
28 . The composite of claim 23 wherein the biopolymer structure is a matt.
Claim 31
Dependent Claim
16 words
29 . The composite of claim 23 wherein the biopolymer structure is a double density foam.
Claim 32
Dependent Claim
21 words
30 . The composite of claim 23 wherein the biopolymer structure is a composite of a biopolymer structure and another structure.
Claim 33
Dependent Claim
22 words
31 . The composite of claim 23 , wherein the biopolymer foam and/or the calcium cement includes or is conditioned with cells.
Claim 34
Dependent Claim
14 words
32 . The composite of claim 31 , wherein said composition is mechanically conditioned.
Claim 35
Dependent Claim
16 words
33 . A bone precursor composition, comprising a calcium cement; and acid or pepsin extracted collagen.
Claim 36
Dependent Claim
16 words
33 . A bone precursor composition, comprising a calcium cement; and acid or pepsin extracted collagen.
Claim 37
Dependent Claim
18 words
34 . The composition of claim 33 , wherein the collagen is in the form of lyophilized collagen.
Claim 38
Dependent Claim
14 words
35 . The composition of claim 33 , wherein the collagen is microfibrillar collagen.
Claim 39
Dependent Claim
35 words
36 . The composition of claim 33 , wherein the calcium cement includes calcium salts selected from the group consisting of calcium pyrophosphate, alpha-calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate, beta-tricalcium phosphate, and mixtures thereof.
Claim 40
Dependent Claim
24 words
37 . The composition of claim 34 , wherein the collagen comprises between about 0.1 to 2.5 weight percent of the composition when dry.
Claim 41
Dependent Claim
25 words
38 . The composition of claim 36 , wherein the ratio by weight of monobasic calcium phosphate monohydrate to beta-tricalcium phosphate is 1:2.5 to 1:3.75.
Claim 42
Dependent Claim
29 words
39 . The composition of claim 33 , wherein the calcium cement is in the form of granules with a diameter of between about 1 to 500 μm inclusive.
Claim 43
Dependent Claim
34 words
40 . A method for preparing an injectable bone precursor composition, comprising combining calcium pyrophosphate, alpha-calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate and beta-tricalcium phosphate, such that an injectable bone precursor composition is prepared.
Claim 44
Dependent Claim
34 words
40 . A method for preparing an injectable bone precursor composition, comprising combining calcium pyrophosphate, alpha-calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate and beta-tricalcium phosphate, such that an injectable bone precursor composition is prepared.
Claim 45
Dependent Claim
25 words
41 . The method of claim 40 , wherein the ratio by weight of monobasic calcium phosphate monohydrate to beta-tricalcium phosphate is 1:2.5 to 1:3.75.
Claim 46
Dependent Claim
35 words
42 . The method of claim 40 , further comprising the step of producing the bone precursor composition as granules of reacted, hardened cement having a diameter of between about 1 to 500 μm inclusive.
Claim 47
Dependent Claim
31 words
43 . The method of claim 40 , further comprising the step of contacting the bone precursor composition with a neutralizing solution such that a neutralized bone precursor composition is prepared.
Claim 48
Dependent Claim
35 words
44 . The method of claim 43 , wherein the neutralizing solution is selected from the group consisting of CAPS, triethanolamine, TES, tricine, HEPES, glycine, phosphate buffer solution, bis tris propane, TAPS, AMP and TRIS.
Claim 49
Dependent Claim
16 words
45 . The method of claim 43 , wherein the neutralizing solution is tribasic sodium phosphate.
Claim 50
Dependent Claim
42 words
46 . A method for producing or repairing connective tissue in a subject, comprising administering an injectable bone precursor composition to the subject, wherein the injectable bone precursor composition comprises calcium pyrophosphate, calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate and beta-tricalcium phosphate.
Claim 51
Dependent Claim
42 words
46 . A method for producing or repairing connective tissue in a subject, comprising administering an injectable bone precursor composition to the subject, wherein the injectable bone precursor composition comprises calcium pyrophosphate, calcium sulfate hemihydrate, monobasic calcium phosphate monohydrate and beta-tricalcium phosphate.
Claim 52
Dependent Claim
25 words
47 . The method of claim 46 , wherein the ratio by weight of monobasic calcium phosphate monohydrate to beta-tricalcium phosphate is 1:2 to 1:3.75.
Claim 53
Dependent Claim
30 words
48 . The method of claim 46 , wherein the bone precursor composition is in the form of granules with a diameter of between about 1 to 500 μm inclusive.
Claim 54
Dependent Claim
19 words
49 . The method of claim 46 , wherein the bone precursor composition includes or is conditioned with cells.
Claim 55
Dependent Claim
17 words
50 . The method of claim 46 , wherein the cells are tissue cells or mesenchymal cells.
Claim 56
Dependent Claim
18 words
51 . The method of claim 46 , wherein the bone precursor composition further comprises an injection vehicle.
Claim 57
Dependent Claim
18 words
52 . The method of claim 46 , wherein the bone precursor composition further comprises a biopolymer structure.
Claim 58
Dependent Claim
20 words
53 . The method of claim 46 , wherein the bone precursor composition further comprises a therapeutic and/or analgesic agent.
Claim 59
Dependent Claim
20 words
54 . The method of claim 46 , wherein the bone precursor composition further comprises acid or pepsin extracted collagen.
Claim 60
Dependent Claim
18 words
55 . The method of claim 46 , wherein the bone precursor composition further comprises extracellular matrix particulates.
Claim 61
Dependent Claim
17 words
56 . The method of claim 46 , wherein the bone precursor composition further comprises pore-generating particles.
References Cited (Backward Citations)
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