US20010041865A1
Expired / Lapsed
US
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Catheter devices and methods for their use in the treatment of calcified vascular occlusions
Assignee: Cordis US Corp
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Filing: 2001-07-23
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Granted: —
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Expires: 2021-07-23
Abstract
Abstract Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
Inventors
- 👤 Dave Delaney
- 👤 Peter Johansson
- 👤 Brent Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:17
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14539; A61B17/00; A61B17/22; A61M; A61M29/00; A61M29/02; A61B2017/22082; A61B2017/22084; A61M25/00; A61M2025/0004; A61M25/0021; A61M25/0023; A61M25/0026; A61M2025/0034; A61M25/10; A61M2025/1043; A61M2025/1052; A61M2025/1093; A61M2025/1095
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
37 words
1 . A catheter device comprising: first, second and third lumens, wherein at least one of said lumens is fabricated from a material sufficient for delivery of an acidic dissolution solution; and a first vascular occlusion means.
Claim 2
Dependent Claim
37 words
1 . A catheter device comprising: first, second and third lumens, wherein at least one of said lumens is fabricated from a material sufficient for delivery of an acidic dissolution solution; and a first vascular occlusion means.
Claim 3
Dependent Claim
19 words
2 . The catheter device according to claim 1 , wherein at least two of said lumens are coaxial.
Claim 4
Dependent Claim
19 words
3 . The catheter device according to claim 1 , wherein said first, second and third lumens are coaxial.
Claim 5
Dependent Claim
41 words
4 . The catheter device according to claim 3 , wherein said first lumen is present in a first fluid delivery member having a distal end, wherein said first fluid delivery member is movable relative to said second and third lumens.
Claim 6
Dependent Claim
35 words
5 . The catheter device according to claim 3 , wherein said second lumen is present in a second fluid delivery member, where said second fluid delivery member is movable relative to said third lumen.
Claim 7
Dependent Claim
26 words
6 . The catheter device according to claim 4 , wherein said first lumen is open at said distal end of said first fluid delivery member.
Claim 8
Dependent Claim
34 words
7 . The catheter device according to claim 4 , wherein said first lumen opens at at least one location on said first fluid delivery member at a site proximal to said distal end.
Claim 9
Dependent Claim
26 words
8 . The catheter device according to claim 7 , wherein said first fluid delivery member comprises a second vascular occlusion means at said distal end.
Claim 10
Dependent Claim
64 words
9 . A catheter device comprising: (a) an inner first tubular member; (b) a middle second tubular member; and (c) a third outer tubular member having a first vascular occlusion means; wherein said tubular members are coaxial and are movable relative to each other, and further wherein each of said tubular members: (i) has a proximal and distal end; and (ii) comprises a lumen.
Claim 11
Dependent Claim
64 words
9 . A catheter device comprising: (a) an inner first tubular member; (b) a middle second tubular member; and (c) a third outer tubular member having a first vascular occlusion means; wherein said tubular members are coaxial and are movable relative to each other, and further wherein each of said tubular members: (i) has a proximal and distal end; and (ii) comprises a lumen.
Claim 12
Dependent Claim
28 words
10 . The catheter device according to claim 9 , wherein said lumen of said first tubular member opens at said distal end of said first tubular member.
Claim 13
Dependent Claim
32 words
11 . The catheter device according to claim 9 , wherein said lumen of said first tubular member opens at a site proximal to said distal end of said first tubular member.
Claim 14
Dependent Claim
25 words
12 . The catheter device according to claim 11 , wherein said first tubular member comprises a second vascular occlusion means at its distal end.
Claim 15
Dependent Claim
139 words
13 . A catheter system comprising: (a) an aspiration catheter comprising an elongated tube having an aspiration lumen ending in an open distal end and an inflatable balloon at said distal end; and (b) a second elongated tube coaxially positioned inside of said aspiration catheter; and (c) at least one of: (i) a total occlusion catheter insert comprising an elongated tube having an open distal end; and (ii) a partial occlusion catheter insert comprising an elongated tube having a sealed distal end, an inflatable balloon at said distal end and at least one infusion port proximal to said inflatable balloon; wherein at least said total and partial occlusion catheter inserts are capable of being slidably positioned within said second elongated tube to produce an annular space at the distal end of said elongated tube through which fluid may flow.
Claim 16
Dependent Claim
139 words
13 . A catheter system comprising: (a) an aspiration catheter comprising an elongated tube having an aspiration lumen ending in an open distal end and an inflatable balloon at said distal end; and (b) a second elongated tube coaxially positioned inside of said aspiration catheter; and (c) at least one of: (i) a total occlusion catheter insert comprising an elongated tube having an open distal end; and (ii) a partial occlusion catheter insert comprising an elongated tube having a sealed distal end, an inflatable balloon at said distal end and at least one infusion port proximal to said inflatable balloon; wherein at least said total and partial occlusion catheter inserts are capable of being slidably positioned within said second elongated tube to produce an annular space at the distal end of said elongated tube through which fluid may flow.
Claim 17
Dependent Claim
22 words
14 . The catheter system according to claim 13 , wherein said system comprises both said partial and total occlusion catheter inserts.
Claim 18
Dependent Claim
27 words
15 . The catheter system according to claim 13 , wherein at least one of said elements (a), (b) and (c) further comprises a separate guidewire lumen.
Claim 19
Dependent Claim
23 words
16 . The catheter system according to claim 13 , wherein said aspiration catheter is in fluid communication with a negative pressure source.
Claim 20
Dependent Claim
25 words
17 . The catheter system according to claim 13 , wherein said second elongate tubular member is in fluid communication with a buffer solution source.
Claim 21
Dependent Claim
23 words
18 . The catheter system according to claim 13 , wherein said catheter inserts are in fluid communication with an acidic solution source.
Claim 22
Dependent Claim
105 words
19 . A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an acidic dissolution fluid; and (ii) a buffer solution; for a period of time sufficient for fluid flow to be enhanced through said vascular site; wherein said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with said acidic dissolution fluid and the remainder of said vascular site is not contacted with solution having a pH of less than about 4; whereby fluid flow is enhanced through said vascular site.
Claim 23
Dependent Claim
105 words
19 . A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an acidic dissolution fluid; and (ii) a buffer solution; for a period of time sufficient for fluid flow to be enhanced through said vascular site; wherein said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with said acidic dissolution fluid and the remainder of said vascular site is not contacted with solution having a pH of less than about 4; whereby fluid flow is enhanced through said vascular site.
Claim 24
Dependent Claim
15 words
20 . The method according to claim 19 , wherein said vascular occlusion comprises calcium.
Claim 25
Dependent Claim
16 words
21 . The method according to claim 19 , wherein said occlusion is a total occlusion.
Claim 26
Dependent Claim
16 words
22 . The method according to claim 19 , wherein said occlusion is a partial occlusion.
Claim 27
Dependent Claim
27 words
23 . The method according to claim 19 , wherein a catheter device according to claim 1 is used to flush said surface of said vascular occlusion.
Claim 28
Dependent Claim
70 words
24 . A system for enhancing fluid flow through a vascular site occupied by a vascular occlusion, said system comprising: (a) a catheter device according to claim 1 ; (b) a manifold; (c) an acidic fluid dissolution reservoir in fluid communication said first lumen; (d) a buffer solution reservoir in fluid communication with said second lumen; and (e) a source of negative pressure in fluid communication with said third lumen.
Claim 29
Dependent Claim
18 words
25 . The system according to claim 24 , wherein said system further includes a balloon inflation means.
Claim 30
Dependent Claim
17 words
26 . The system according to claim 24 , wherein said balloon inflation means is a syringe.
Claim 31
Dependent Claim
16 words
27 . The system according to claim 24 , wherein said system further comprises a guidewire.
Claim 32
Dependent Claim
30 words
28 . A kit for use in enhancing fluid flow through a vascular site occupied by a vascular occlusion, said kit comprising: a catheter device according to claim 1 .
Claim 33
Dependent Claim
21 words
29 . The kit according to claim 28 , wherein said kit comprises the catheter system according to claim 13 .
Claim 34
Dependent Claim
16 words
30 . The kit according to claim 28 , wherein said kit further comprises a guidewire.
Claim 35
Dependent Claim
17 words
31 . The kit according to claim 28 , wherein said kit further comprises an imaging agent.
Claim 36
Dependent Claim
18 words
32 . The kit according to claim 28 , wherein said kit further comprises an acidic dissolution solution.
Claim 37
Dependent Claim
17 words
33 . The kit according to claim 28 , wherein said kit further comprises a buffer solution.
References Cited (Backward Citations)
US4329994A
Cited
US4573966A
Cited
US4610662A
Cited
US4636195A
Cited
US4445892A
Cited
US4681104A
Cited
US4838881A
Cited
US4690672A
Cited
US4824436A
Cited
US4655746A
Cited
US4911163A
Cited
US4976733A
Cited
US5059178A
Cited
US5195955A
Cited
US5090960A
Cited
US5222941A
Cited
US5785675A
Cited
US5370609A
Cited
US5496267A
Cited
US5207648A
Cited
US5167623A
Cited
US5149330A
Cited
US5443446A
Cited
US5167628A
Cited
US5380284A
Cited
US5462529A
Cited
US5542937A
Cited
US5833650A
Cited
US5681336A
Cited
US5624396A
Cited
US6013068A
Cited
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