US20010039411A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
Assignee: Cordis US Corp
•
Filing: 2001-01-30
•
Granted: —
•
Expires: 2021-01-30
Abstract
Abstract Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
Inventors
- 👤 Peter Johansson
- 👤 David Delaney
- 👤 Brent Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:52
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14539; A61B17/00; A61B17/22; A61K; A61K31/00; A61K33/00; A61K45/00; A61K45/06; A61M; A61M25/00; A61M25/10; A61M25/1011; A61B2017/22082; A61B2017/22084; A61M2025/0004; A61M25/0021; A61M25/0023; A61M25/0026; A61M2025/0034; A61M25/01; A61M2025/0175; A61M2025/1015; A61M2025/1043; A61M2025/105; A61M2025/1052; A61M2025/109; A61M25/0067; A61M25/0068; A61M25/007
Claims Analysis
Total Claims: 57
Claim 1
Independent Claim
102 words
1 . A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) a dissolution fluid; and (ii) a dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 2
Dependent Claim
102 words
1 . A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) a dissolution fluid; and (ii) a dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 3
Dependent Claim
18 words
2 . The method according to claim 1 , wherein said vascular occlusion at least comprises organic matter.
Claim 4
Dependent Claim
18 words
3 . The method according to claim 1 , wherein said vascular occlusion at least comprises inorganic matter.
Claim 5
Dependent Claim
19 words
4 . The method according to claim 1 , wherein said vascular occlusion comprises both organic and inorganic matter.
Claim 6
Dependent Claim
19 words
5 . The method according to claim 1 , wherein said dissolution fluid is an organic matter dissolution fluid.
Claim 7
Dependent Claim
32 words
6 . The method according to claim 1 , wherein said organic matter dissolution fluid comprises an active agent selected from the group consisting of enzymes, surfactants, oxidizing agents and thrombolytic agents.
Claim 8
Dependent Claim
19 words
7 . The method according to claim 1 , wherein said dissolution fluid is an inorganic matter dissolution fluid.
Claim 9
Dependent Claim
20 words
8 . The method according to claim 7 , wherein said inorganic matter dissolution fluid is an acidic dissolution fluid.
Claim 10
Dependent Claim
16 words
9 . The method according to claim 1 , wherein said occlusion is a total occlusion.
Claim 11
Dependent Claim
16 words
10 . The method according to claim 1 , wherein said occlusion is a partial occlusion.
Claim 12
Dependent Claim
23 words
11 . The method according to claim 1 , wherein a catheter device is used to flush said surface of said vascular occlusion.
Claim 13
Dependent Claim
19 words
12 . The method according to claim 11 , wherein said catheter device comprises at least three different lumens.
Claim 14
Dependent Claim
19 words
13 . The method according to claim 11 , wherein said catheter device comprises at least four different lumens.
Claim 15
Dependent Claim
116 words
14 . A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an organic matter dissolution fluid; and (ii) an organic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 16
Dependent Claim
116 words
14 . A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an organic matter dissolution fluid; and (ii) an organic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 17
Dependent Claim
31 words
15 . The method according to claim 14 , wherein said organic matter dissolution fluid comprises an active agent selected from the group consisting of enzymes, surfactants, oxidizing and thrombolytic agents.
Claim 18
Dependent Claim
21 words
16 . The method according to claim 14 , wherein said organic matter dissolution fluid attenuating agent is an aqueous fluid.
Claim 19
Dependent Claim
19 words
17 . The method according to claim 14 , wherein said organic matter dissolution fluid comprises an oxidizing agent.
Claim 20
Dependent Claim
22 words
18 . The method according to claim 17 , wherein said organic matter dissolution fluid attenuating agent comprises an aqueous buffer solution.
Claim 21
Dependent Claim
19 words
19 . The method according to claim 18 , wherein said wherein said organic matter dissolution fluid comprises surfactant.
Claim 22
Dependent Claim
17 words
20 . The method according to claim 14 , wherein said vascular occlusion is a total occlusion.
Claim 23
Dependent Claim
17 words
21 . The method according to claim 14 , wherein said vascular occlusion is a partial occlusion.
Claim 24
Dependent Claim
116 words
22 . A method of enhancing fluid flow through a vascular site occupied by an inorganic matter comprising vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an inorganic matter dissolution fluid; and (ii) an inorganic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated inorganic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated inorganic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 25
Dependent Claim
116 words
22 . A method of enhancing fluid flow through a vascular site occupied by an inorganic matter comprising vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) an inorganic matter dissolution fluid; and (ii) an inorganic matter dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated inorganic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated inorganic matter dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 26
Dependent Claim
18 words
23 . The method according to claim 22 , wherein said inorganic matter is a calcium phosphate mineral.
Claim 27
Dependent Claim
19 words
24 . The method according to claim 22 , wherein said inorganic matter dissolution fluid is an acidic solution.
Claim 28
Dependent Claim
21 words
25 . The method according to claim 24 , wherein said inorganic matter dissolution fluid attenuating fluid is a buffer solution.
Claim 29
Dependent Claim
17 words
26 . The method according to claim 22 , wherein said vascular occlusion is a total occlusion.
Claim 30
Dependent Claim
17 words
27 . The method according to claim 22 , wherein said vascular occlusion is a partial occlusion.
Claim 31
Dependent Claim
111 words
28 . A method of enhancing fluid flow through a vascular site occupied by vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) a dissolution fluid that dissolves both organic and inorganic matter; and (ii) a dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 32
Dependent Claim
111 words
28 . A method of enhancing fluid flow through a vascular site occupied by vascular occlusion, said method comprising: simultaneously flushing said vascular site with: (i) a dissolution fluid that dissolves both organic and inorganic matter; and (ii) a dissolution fluid attenuating fluid; for a period of time sufficient for fluid flow to be enhanced through said vascular site; with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid; whereby fluid flow is enhanced through said vascular site.
Claim 33
Dependent Claim
16 words
29 . The method according to claim 28 , wherein said dissolution fluid comprises an acid.
Claim 34
Dependent Claim
16 words
30 . The method according to claim 28 , wherein said dissolution fluid comprises a surfactant.
Claim 35
Dependent Claim
19 words
31 . The method according to claim 28 , wherein said dissolution fluid attenuating fluid is a buffer solution.
Claim 36
Dependent Claim
17 words
32 . The method according to claim 28 , wherein said vascular occlusion is a total occlusion.
Claim 37
Dependent Claim
17 words
33 . The method according to claim 28 , wherein said vascular occlusion is a partial occlusion.
Claim 38
Dependent Claim
49 words
34 . A system for use in enhancing fluid flow through a vascular site occupied by an vascular occlusion, said system comprising: a means for simultaneously flushing said vascular site with a dissolution fluid and a dissolution fluid attenuating fluid; a dissolution fluid; and an dissolution fluid attenuating fluid.
Claim 39
Dependent Claim
49 words
34 . A system for use in enhancing fluid flow through a vascular site occupied by an vascular occlusion, said system comprising: a means for simultaneously flushing said vascular site with a dissolution fluid and a dissolution fluid attenuating fluid; a dissolution fluid; and an dissolution fluid attenuating fluid.
Claim 40
Dependent Claim
38 words
35 . The system according to claim 34 , wherein said means for simultaneously flushing said vascular site with a dissolution fluid and a dissolution attenuating fluid comprises two different fluid introducing means and a fluid aspiration means.
Claim 41
Dependent Claim
17 words
36 . The system according to claim 34 , wherein said flushing means is a catheter means.
Claim 42
Dependent Claim
34 words
37 . The system according to claim 34 , wherein said system further comprises: (a) a manifold; (b) a dissolution fluid reservoir; (d) a dissolution fluid attenuating; and (e) a source of negative pressure.
Claim 43
Dependent Claim
18 words
38 . The system according to claim 34 , wherein said system further includes a balloon inflation means.
Claim 44
Dependent Claim
17 words
39 . The system according to claim 38 , wherein said balloon inflation means is a syringe.
Claim 45
Dependent Claim
16 words
40 . The system according to claim 34 , wherein said system further comprises a guidewire.
Claim 46
Dependent Claim
49 words
41 . A kit for use in enhancing fluid flow through a vascular site occupied by a vascular occlusion, said kit comprising: a means for flushing said vascular site with a dissolution fluid and a dissolution fluid attenuating fluid; and instructions for practicing the method of claim 1 .
Claim 47
Dependent Claim
21 words
42 . The kit according to claim 41 , wherein said kit further comprises a dissolution fluid or a precursor(s) thereof.
Claim 48
Dependent Claim
22 words
43 . The kit according to claim 41 , wherein said kit further comprises a dissolution fluid attenuating fluid or precursors thereof.
Claim 49
Dependent Claim
16 words
44 . The kit according to claim 41 , wherein said kit further comprises a guidewire.
Claim 50
Dependent Claim
12 words
45 . A lesion dissolution fluid comprising: an acid; and a surfactant.
Claim 51
Dependent Claim
12 words
45 . A lesion dissolution fluid comprising: an acid; and a surfactant.
Claim 52
Dependent Claim
16 words
46 . The fluid according to claim 45 , wherein said fluid further comprises a salt.
Claim 53
Dependent Claim
16 words
47 . The fluid according to claim 45 , wherein said acid is an inorganic acid.
Claim 54
Dependent Claim
16 words
48 . The fluid according to claim 45 , wherein said inorganic acid is hydrogen chloride.
Claim 55
Dependent Claim
28 words
49 . The fluid according to claim 45 , wherein said surfactant is selected from the group consisting of cationic surfactants, anionic surfactants, zwitterionic surfactants and nonionic surfactants.
Claim 56
Dependent Claim
16 words
50 . The fluid according to claim 49 , wherein said surfactant is a cationic surfactant.
Claim 57
Dependent Claim
17 words
51 . The fluid according to claim 50 , wherein said cationic surfactant is sodium dodecyl sulfate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.