Preparation of prolonged action complex with polylayer structure

Abstract

Abstract PURPOSE:A prolonged action complex capable of releasing a physiologically active substance at long intervals, obtained by forming a core including a physiologically active substance, an interval layer not including it, and an outermost layer including it successively in this order. CONSTITUTION:A physiologically active substance (e.g., testrone) is blended with a vinyl type polymerizable monomer (e.g., hydroxyethyl acrylate) to be supercooled, a natural or synthetic high polymer substance (e.g., polymethyl methacrylate) and a substance system selected from their mixture, to give a blend which is formed into a given shape and processed by a physical operation to give a prolonged action complex. A film consisting of a substance system equal to the above-mentioned substance system is formed on the surface of the prolonged action complex, to form an interval layer having no physiologically active substance. A layer including a physiologically active substance is made on the interval layer. Formation of polylayer is carried out arbitrarily in the order. The release of the physiologically active substance is carried out periodically.

Inventors

• 👤 Isao Kaetsu
• 👤 Masaru Yoshida

Bibliographic Details