GB2169386A
Expired / Lapsed
GB
⏱️ 0.0 years remaining
Prosthetic heart valve and method of manufacture
Assignee: MITRAL MED INT
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Filing: 1986-01-23
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Granted: —
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Expires: 2006-01-23
Abstract
Abstract The valve comprises an element (11) of natural tissue mounted on a cloth-covered stent and suture ring assembly (13), the stent having a series of circumferentially spaced commissure posts (25',25'',25''') separated by scalloped portions (26) above a common annular base. In making the valve a substantially rectangular section of natural tissue, e.g. bovine pericardium, is cut, cleaned in saline solution, and partially fixed in a glutaraldehyde solution. The tissue section is then secured by stitching (40,42,43) onto the box and posts of the stent, the latter being mounted on a mandrel (30). The assembly is then dipped in saline solution causing the tissue to conform to depressions (33) in the mandrel and form leaves (15) of the valve element; thereafter the element is fixed in glutaraldehyde solution and the valve removed from the mandrel. <IMAGE>
Inventors
- 👤 Robert P Totten
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-10-22 21:09
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61F2/2415; A61L27/36; A61L27/3683; A61F2220/00; A61F2220/0025; A61F2220/0075
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
218 words
A method of preparing a tissue valve element for a prosthetic heart valve in which a stent is formed having an outer fabric covering and circumferentially spaced commissure posts, comprising the steps of: forming a rec tangular strip of natural tissue;;,artially fixing the strip in a first fixative solution; positioning the strip on the stent with the length of the strip circumscribing the base of the stent and the stent being of a width to extend from the base of the stent beyond the terminal ends of the commissure posts; inserting a leaflet-form ing tool into the stent, such that recessed areas in the tool extend between the commis sure posts to define with the posts the de sired leaflet configuration to be assumed by the strip; immersing the assembled stent, leaflet-forming tool and tissue in a second so lution effective to cause the tissue to assume the leaflet configuration of the leaflet-forming tool; immersing the assembled stent, leaflet forming tool and tissue in a third, fixative, so lution for a sufficient length of time to perma nently shape the strip to conform to the leaflet configuration of the leaflet-forming tool without the application of pressure; and re moving the assembled stent, leaflet-forming tool and strip from the solution and removing the tool from the stent and strip.
Claim 2
Independent Claim
218 words
A method of preparing a tissue valve element for a prosthetic heart valve in which a stent is formed having an outer fabric covering and circumferentially spaced commissure posts, comprising the steps of: forming a rec tangular strip of natural tissue;;,artially fixing the strip in a first fixative solution; positioning the strip on the stent with the length of the strip circumscribing the base of the stent and the stent being of a width to extend from the base of the stent beyond the terminal ends of the commissure posts; inserting a leaflet-form ing tool into the stent, such that recessed areas in the tool extend between the commis sure posts to define with the posts the de sired leaflet configuration to be assumed by the strip; immersing the assembled stent, leaflet-forming tool and tissue in a second so lution effective to cause the tissue to assume the leaflet configuration of the leaflet-forming tool; immersing the assembled stent, leaflet forming tool and tissue in a third, fixative, so lution for a sufficient length of time to perma nently shape the strip to conform to the leaflet configuration of the leaflet-forming tool without the application of pressure; and re moving the assembled stent, leaflet-forming tool and strip from the solution and removing the tool from the stent and strip.
Claim 3
Dependent Claim
26 words
A method according to claim 1, wherein the first solution is a glutaraidehyde solution and the strip is partially fixed therein without the application of pressure.
Claim 4
Dependent Claim
32 words
A method according to claim 1 or 2, wherein the third fixative solution is a glutaral- dehyde solution and the assembly is repeatedly immersed in the fixative solution for spaced time intervals.
Claim 5
Dependent Claim
26 words
A method according to claim 3, wherein the stent and the strip are immersed in the third fixative solution following removal of the leafletforming tool therefrom.
Claim 6
Dependent Claim
33 words
A method according to any one of claim 1, 2, 3 or 4, wherein the second solution is a saline solution, the strip is immersed therein and shaped without the application of pressure.
Claim 7
Independent Claim
33 words
A method according to claims 1 to 5, wherein the positioning of the tissue strip on the stent is accomplished without pressure by immersing the stent and the strip in a saline solution.
Claim 8
Dependent Claim
42 words
A method according to claim 2 or any claim appendant thereto, wherein the tissue strip is trimmed above the terminal ends of the commissure posts following the immersion to define upper converging edges of the tissue strip in the said leaflet configuration.
Claim 9
Independent Claim
55 words
A method of preparing a tissue valve element for a prosthetic heart valve, substantially as described herein with reference to the accompanying drawings. Printed in the United Kingdom for Her Majesty's Stationery Office, Did 8818935, 1986, 4235. Published at The Patent Office, 25 Southampton Buildings, London, WC2A l AY, from which copies may be obtained.
Claim 10
Independent Claim
55 words
A method of preparing a tissue valve element for a prosthetic heart valve, substantially as described herein with reference to the accompanying drawings. Printed in the United Kingdom for Her Majesty's Stationery Office, Did 8818935, 1986, 4235. Published at The Patent Office, 25 Southampton Buildings, London, WC2A l AY, from which copies may be obtained.
References Cited (Backward Citations)
No citation records indexed.
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