GB2167662A
Expired / Lapsed
GB
⏱️ 0.0 years remaining
Sustained release devices
Assignee: CRB Virbac SA
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Filing: 1985-11-12
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Granted: —
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Expires: 2005-11-12
Abstract
Abstract Sustained release devices have an insoluble polymer and glycerol ester matrix containing an active substance. Preferred devices are solid implants for subcutaneous administration, containing one or more anabolic substances incorporated in the matrix. The implants give sustained release of the anabolic substance especially in farm animals. The anabolic substance is e.g. estradiol, testosterone, progesterone, nandrolone, trembolone etc. The insoluble polymer may be polypropylene, polyethylene, pvc, polystyrene etc, and the ester can be glycerol palmitostearate, stearate or behenate.
Inventors
- 👤 Pierre Richard Dick
- 👤 Jacques Alexandre Cuvelier
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-10-23 04:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2022; A61K9/2027; A61K9/2009
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
27 words
A sustained-release device which consists of a solid matrix based on hydrophobic insoluble polymers associated with glycerol esters, so-called bulking substances and one or more active substances.
Claim 2
Dependent Claim
27 words
A sustained-release device which consists of a solid matrix based on hydrophobic insoluble polymers associated with glycerol esters, so-called bulking substances and one or more active substances.
Claim 3
Dependent Claim
33 words
A sustained-release device as claimed in claim 1, wherein the active substance or substances are anabolic agents (estrogens, androgens or progestogens) which can represent from 5 to 60% by weight of the composition.
Claim 4
Dependent Claim
45 words
A sustained-release device as claimed in claim 1, wherein the solid matrix is baded on insoluble polymers such as polypropylene, polyethylene, polyvinyl chloride, polystyrene, polymethacrylate and ethylvinyl acetate, associated with glycerol esters, which can together represent from 10 to 50% by weight of the composition.
Claim 5
Dependent Claim
28 words
A device as claimed in claim 1, produced for administration by subcutaneous implantation in animals and more especially cattle and sheep, and defined as a sustained-release anabolic implant.
Claim 6
Dependent Claim
26 words
A sustained-release anabolic implant as claimed in claims 2 to 4, characterized by its growth factor property whose physiological action lasts between 50 and 200 days.
Claim 7
Dependent Claim
17 words
A sustained-release anabolic implant as claimed in claims 2 to 4, manufactured industrially by the compression technique.
Claim 8
Dependent Claim
40 words
A sustained-release anabolic implant as claimed in claims 2 to 4, wherein the active substances are taken from the group comprising: 17ss-estradiol or its esters, progesterone or its esters, testosterone or its esters, nandrolone, trembolone or its esters and zeranol.
Claim 9
Dependent Claim
37 words
A sustained-release anabolic implant as claimed in claim 7, which consists of the anabolic substance 17ss-estradiol, an insoluble matrix based on polypropylene and glycerol stearate, and bulking agents enabling it to be manufactured industrially by direct compression.
Claim 10
Dependent Claim
37 words
A sustained-release anabolic implant which consists of a mixture of the anabolic substances 17ss- estradiol and testosterone, an insoluble matrix based on polypropylene and glycerol stearate, and bulking agents enabling it to be manufactured industrially by compression.
Claim 11
Dependent Claim
37 words
A sustained-release anabolic implant which consists of a mixture of the anabolic substances 17ss- estradiol and testosterone, an insoluble matrix based on polypropylene and glycerol stearate, and bulking agents enabling it to be manufactured industrially by compression.
Claim 12
Dependent Claim
37 words
A sustained-release anabolic implant which consists of a mixture of the anabolic substances 17(3- estradiol and progesterone, an insoluble matrix based on polypropylene and glycerol stearate, and bulking agents enabling it to be manufactured industrially by compression.
Claim 13
Dependent Claim
37 words
A sustained-release anabolic implant which consists of a mixture of the anabolic substances 17(3- estradiol and progesterone, an insoluble matrix based on polypropylene and glycerol stearate, and bulking agents enabling it to be manufactured industrially by compression.
References Cited (Backward Citations)
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