GB2102811A
Expired / Lapsed
GB
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A tissue adhesive and a method of producing the same
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1982-07-06
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Granted: —
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Expires: 2002-07-06
Abstract
Abstract A tissue adhesive based on human or animal proteins contains factor XIII, fibrinogen and an antibiotic. In order to achieve a high straining capacity of the adherences and a retarded antimicrobial efficacy, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, amounts to at least 500. The antibiotic is chosen among amino-glucosides, beta- lactams, polypeptides or tetracyclines. In a method of producing the tissue adhesive the concentration ratio of factor XIII to fibrinogen is adjusted in a fibrinogen-containing blood plasma fraction by the addition of factor XIII. The antibiotic is added either before deepfreezing or lyophilization of the resulting preparation, or after thawing or reconstitution of the same.
Inventors
- 👤 Heinz Redl
- 👤 Thomas Seelich
- 👤 Yendra Linnau
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-10-22 23:20
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
58 words
A deepfrozen or lyophilized tissue adhesive based on human or animal proteins which comprises factor XIII, fibrinogen and an antibiotic, wherein the ratio of factor XIII to fibrinogen, expressed in units of factor Xlil per gram of fibrinogen, amounts to at least 500, and said antibiotic is selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines.
Claim 2
Dependent Claim
58 words
A deepfrozen or lyophilized tissue adhesive based on human or animal proteins which comprises factor XIII, fibrinogen and an antibiotic, wherein the ratio of factor XIII to fibrinogen, expressed in units of factor Xlil per gram of fibrinogen, amounts to at least 500, and said antibiotic is selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines.
Claim 3
Dependent Claim
23 words
A deepfrozen tissue adhesive as set forth in claim 1, wherein factor XIII is contained in an amount of at least 40 units/ml.
Claim 4
Dependent Claim
35 words
A lyophilized tissue adhesive as set forth in claim 1, wherein at least 33 % by weight of fibrinogen is contained, factor Xlil being present in an amount of at least 170 units/gram of lyophilisate.
Claim 5
Dependent Claim
32 words
A tissue adhesive as set forth in claim 1, further comprising a plasmin inhibitor or plasminogenactivator inhibitor selected from the group consisting of aprotinin, a2-antiplasmin, a2-macroglobulin, a1-antitrypsin, e-aminocaproic acid and tranexamic acid.
Claim 6
Dependent Claim
36 words
A tissue adhesive as set forth in claim 1, comprising a first component and a second component, said first component containing factor XIII and fibrinogen and said second component containing said antibiotic, thrombin and bivalent calcium.
Claim 7
Dependent Claim
42 words
A tissue adhesive as set forth in claim 4, comprising a first component and a second component, said first component containing factor XIII, fibrinogen and said plasmin inhibitor or plasminogen-activator inhibitor and said second component containing said antibiotic, thrombin and bivalent calcium.
Claim 8
Dependent Claim
21 words
A tissue adhesive as set forth in claim 1,wherein said antibiotic is present in the form of a hardly soluble derivative.
Claim 9
Independent Claim
85 words
A method of producing a tissue adhesive based on human or animal proteins and comprising factor
XIII, fibrinogen, a plasmin inhibitor or plasminogen-activator inhibitor, and an antibiotic selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines, which method comprises the steps of adjusting in a fibrinogen-containing blood plasma fraction a concentration ratio of factor XIII to fibrinogen, expressed in units of factor Xlil/gram of fibrinogen, of at least 500 by adding factor XIII, adding said antibiotic, and deepfreezing or lyophilizing the resulting preparation.
Claim 10
Independent Claim
85 words
A method of producing a tissue adhesive based on human or animal proteins and comprising factor
XIII, fibrinogen, a plasmin inhibitor or plasminogen-activator inhibitor, and an antibiotic selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines, which method comprises the steps of adjusting in a fibrinogen-containing blood plasma fraction a concentration ratio of factor XIII to fibrinogen, expressed in units of factor Xlil/gram of fibrinogen, of at least 500 by adding factor XIII, adding said antibiotic, and deepfreezing or lyophilizing the resulting preparation.
Claim 11
Independent Claim
96 words
A method of producing a tissue adhesive based on human or animal proteins and comprising factor
XIII, fibrinogen, a plasmin inhibitor or plasminogen-activator inhibitor, and an antibiotic selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines, which method comprises the steps of
adjusting in a fibrinogen-containing blood plasma fraction a concentration ratio of factor Xlil to fibrinogen, expressed in units of factor Xlil/gram of fibrinogen, of at least 500 by adding factor XIII,
deepfreezing or lyophilizing the resulting preparation,
thawing or reconstituting the preparation, and
combining the preparation with a solution containing said antibiotic.
Claim 12
Independent Claim
96 words
A method of producing a tissue adhesive based on human or animal proteins and comprising factor
XIII, fibrinogen, a plasmin inhibitor or plasminogen-activator inhibitor, and an antibiotic selected from the group consisting of aminoglucosides, betalactams, polypeptides and tetracyclines, which method comprises the steps of
adjusting in a fibrinogen-containing blood plasma fraction a concentration ratio of factor Xlil to fibrinogen, expressed in units of factor Xlil/gram of fibrinogen, of at least 500 by adding factor XIII,
deepfreezing or lyophilizing the resulting preparation,
thawing or reconstituting the preparation, and
combining the preparation with a solution containing said antibiotic.
Claim 13
Dependent Claim
72 words
A method as set forth in claim 8 or 9, further comprising washing said fibrinogen-containing blood plasma fraction with a buffer solution in a washing procedure, and wherein said washing procedure is carried out until a factor Xlil concentration of 200 units of factor Xlil/gram of fibrinogen is reached, whereupon factor Xlil is added in an amount of at least 300 units/gram of fibrinogen in the form of a concentrate or lyophilisate.
Claim 14
Dependent Claim
13 words
A tissue adhesive substantially as hereinbefore described with reference to the accompanying examples.
Claim 15
Dependent Claim
13 words
A tissue adhesive substantially as hereinbefore described with reference to the accompanying examples.
Claim 16
Independent Claim
12 words
A method substantially as hereinbefore described with reference to the accompanying examples.
Claim 17
Independent Claim
12 words
A method substantially as hereinbefore described with reference to the accompanying examples.
References Cited (Backward Citations)
No citation records indexed.
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