EP1111386A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Test strip for the assay of an analyte in a liquid sample
Assignee: Siemens Healthcare Diagnostics Inc
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Filing: 2000-12-05
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Granted: —
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Expires: 2020-12-05
Abstract
Abstract An improved test strip for determining the presence or concentration of unknown or a constituent in a liquid test sample is disclosed. The test strip comprises a support strip and a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with the constituent of interest to produce a detectable or measurable response. The test strip further comprises an infrared dye, applied either to the support strip or incorporated into a test pad, which ensures proper alignment of the test strip in an apparatus having a detection system for the detectable or measurable response. The improved test strip reduces the number of erroneous assays for the constituent of interest.
Inventors
- 👤 Paul F. Corey
- 👤 Michael J. Pugia
- 👤 Gary E. Rehm
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 04:46
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/173076
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
75 words
A test strip for determining the
presence or concentration of one or more predetermined
analytes in a liquid test sample comprising: (a) a support handle; (b) one or more test pads positioned on
the support handle, each test pad comprising (i) a
carrier matrix incorporating (ii) a reagent composition
capable of interacting with a predetermined
analyte to provide a detectable response; and (c) an infrared dye positioned at a predetermined
location on the test strip.
Claim 2
Dependent Claim
23 words
The test strip of claim 1 wherein
about 0.05 to about 0.3 micrograms of the infrared
dye are positioned on the test strip.
Claim 3
Dependent Claim
20 words
The test strip of claim 1 wherein the
infrared dye is positioned on the support handle of
the test strip.
Claim 4
Dependent Claim
18 words
The test strip of claim 1 wherein the
infrared dye is incorporated into one or more test
pad.
Claim 5
Dependent Claim
28 words
The test strip of claim 1 wherein the
infrared dye is incorporated into one or more test
pad and positioned on the support handle of the test
strip.
Claim 6
Dependent Claim
19 words
The test strip of claim 1 wherein the
infrared dye absorbs infrared radiation at least at
one infrared wavelength.
Claim 7
Dependent Claim
14 words
The test strip of claim 6 wherein the
infrared dye lacks a visible color.
Claim 8
Dependent Claim
47 words
The test strip of claim 1 wherein the
infrared dye is selected from the group consisting
of 5,5'-dichloro-11-diphenylamino-3,3'-diethyl-10,12-ethylenethiatricarbocyanine
perchlorate, 3-(5-carboxypentyl)
-2- [2- [3 [[3- (5-carboxypentyl) -1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-ethylidene]
-2- (2-sulfoethylthio)-1-cyclohexene-1-yl]ethenyl]1,1-dimethyl-1H-benz[e]
indolinium, 3-(5-carboxypentyl)
-2- [2- [3- [[3- (5-carboxypentyl) -1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-ethylidene]
-2- (n-hexylthio)-1-cyclohexen-1-yl]-ethenyl]-1,1-dimethyl-1H-benz
[e] indolium, copper
(II) 5,9,14,18,23,27,32,36-octabutoxy-2,3-napht-halocyanine,
5,9,14,18,23,27,32,36-octabutoxy-2,3-naphthalocyanine,
and mixtures thereof.
Claim 9
Dependent Claim
25 words
The test strip of claim 1 wherein the
infrared dye is incorporated into a test pad capable
of assaying for nitrite or for occult blood.
Claim 10
Dependent Claim
29 words
The test strip of claim 1 wherein the
infrared dye is applied to the support handle and is
positioned adjacent to a test pad capable of assaying
for nitrite.
Claim 11
Independent Claim
138 words
A method of monitoring alignment of a
test strip in an optical pathway of a detection
apparatus comprising: (a) providing a test strip, said test
strip comprising (i) a support handle; (ii) one or more test pads positioned
on the support handle, each test pad comprising
(i) a carrier matrix incorporating (ii) a reagent
composition capable of interacting with a
predetermined analyte to provide a detectable response;
and (iii) an infrared dye positioned at
a predetermined location on the test strip; (b) inserting the test strip in the detection
apparatus; (c) illuminating the predetermined location
of the infrared dye on the test strip with
infrared radiation; (d) measuring a reflectance of infrared
radiation from the predetermined location on the
test strip; and (e) correlating the reflectance measurement
to the alignment of the test strip in the detection
apparatus.
Claim 12
Dependent Claim
13 words
The method of claim 11 wherein the
detection apparatus is a scanning-type apparatus.
Claim 13
Dependent Claim
13 words
The method of claim 11 wherein the
detection apparatus is a camera-type apparatus.
Claim 14
Dependent Claim
23 words
The method of claim 11 wherein the
test strip is rejected by the detection apparatus
when misaligned by about 0.05 inch or greater.
Claim 15
Dependent Claim
25 words
The method of claim 11 wherein misalignment
of the test strip in the decection apparatus
by an amount of 0.030 inch or greater is detected.
References Cited (Backward Citations)
No citation records indexed.
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