EP0810004A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Radiation-emitting flow-through temporary stent
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 1997-05-08
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Granted: —
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Expires: 2017-05-08
Abstract
Abstract The invention is directed to an intravascular catheter with an expandable region suitable for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen. The expandable region centers the radiation dose within the body lumen, such as a coronary artery, and permits blood flow through the expandable region while radiation therapy is provided. <IMAGE>
Inventors
- 👤 Joseph P. Loeffler
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 23:53
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002; A61M; A61M25/00; A61M25/01; A61M2025/0183; A61M25/10; A61M2025/1043; A61M2025/1047; A61M29/00; A61M29/02; A61N2005/1003
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
224 words
An intravascular catheter (10) for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation dose to the body lumen, comprising: an elongated catheter body (11) having a proximal end and a distal end; an expandable region (12) disposed at the distal end of the elongated catheter body, the expandable region having a proximal end (14) and a distal end (15); a guide wire lumen (20) extending through the elongated catheter body (11) from the proximal end to the distal end for receiving a guide wire (24); a control wire lumen (17) disposed in the elongated catheter body and extending from the proximal end to the expandable region, the control wire lumen adapted to receive a control wire (13) for effecting axial movement of the expandable region; and a blind lumen (50) disposed in the elongated catheter body and extending from the proximal end and terminating at a position near the distal end of the expandable region, the blind lumen adapted to receive a radiation source wire (51), whereby the control wire is moved proximally to expand the expandable region into contact with the body lumen and permit perfusion of blood through the expandable region while the radiation source wire is inserted in the blind lumen to provide a radiation source to the body lumen.
Claim 2
Dependent Claim
270 words
An intravascular catheter for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation dose to the body lumen, comprising: an elongated catheter body (60) having a proximal end and a distal end and having an outer shaft (61) and an inner shaft (62) in a coaxial configuration; an expandable region (66) disposed at the distal end of the elongated catheter body, the expandable region having a proximal end (65) and a distal end (69), the proximal end (65) of the expandable region being attached to a distal end (64) of the outer shaft, and the distal end (69) of the expandable region being attached to the distal end (68) of the inner shaft; means for providing relative axial movement between the outer shaft and the inner shaft for expanding and contracting the expandable region; a guide wire lumen (20) extending through the elongated catheter body from the proximal end to the distal end for receiving a guide wire (24); and a blind lumen (50) disposed in the elongated catheter body and extending from the proximal end of the catheter body and terminating at a position near the distal end of the expandable region, the blind lumen adapted to receive a radiation source wire (51), whereby the outer shaft (61) is moved axially in relation to the inner shaft (62) to expand the expandable region into contact with the body lumen and permit perfusion of blood through the expandable region while the radiation source wire (51) is inserted in the blind lumen to provide a radiation source to the body lumen.
Claim 3
Dependent Claim
185 words
An intravascular catheter for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen, comprising: an elongated catheter body having a proximal end and a distal end; an expandable region disposed at the distal end of the elongated catheter body, the expandable region having a proximal end and a distal end; a guide wire lumen extending through the elongated catheter body from the proximal end to the distal end for receiving a guide wire; means for expanding and contracting the expandable region; and a blind lumen disposed in the elongated catheter body and extending from the proximal end and terminating at a position near the distal end of the expandable region, the blind lumen adapted to receive a radiation source wire, whereby the means for expanding the expandable region is engaged to expand the expandable region into contact with the body lumen and permit perfusion of blood through the expandable region while the radiation source wire is inserted in the blind lumen to provide a radiation source to the body lumen.
Claim 4
Dependent Claim
30 words
The catheter of any of claims 1 to 3, wherein the expandable region (12) is formed from the distal end of the elongated catheter body (11) in a one-piece configuration.
Claim 5
Dependent Claim
78 words
The catheter of claim 4 when dependent on claim 1, wherein the control wire (13) is attached to the distal end (15) of the expandable region and withdrawing the control wire proximally will shorten the expandable region (12) thereby expanding it into contact with the body lumen, the distal end (15) of the expandable region moving axially in the proximal direction while the proximal end (14) of the expandable region remains fixed relative to the elongated catheter body.
Claim 6
Dependent Claim
40 words
The catheter of claim 2, wherein the relative axial movement between the outer shaft and inner shaft shortens or lengthens the expandable region thereby expanding it into contact with the inner wall of the body lumen or contracting it, respectively.
Claim 7
Dependent Claim
24 words
The catheter of claim 2, wherein the relative axial movement between the outer shaft and inner shaft is controlled by a rack and pinion.
Claim 8
Dependent Claim
22 words
The catheter of claim 2, wherein the relative axial movement between the outer shaft and inner shaft is controlled by ratcheting means.
Claim 9
Dependent Claim
22 words
The catheter of claim 2, wherein the relative axial movement between the outer shaft and inner shaft is controlled by gearing means.
Claim 10
Dependent Claim
32 words
The catheter of any of claims 1 to 3, wherein the radiation source wire has a proximal end and a distal end, the distal end having a radiation source (52) associated therewith.
Claim 11
Dependent Claim
35 words
The catheter of any of claims 1 to 3 wherein radiation source wire (51) delivers a low dosage of radiation to the body lumen at position adjacent the distal end of the blind lumen (50).
Claim 12
Dependent Claim
36 words
The catheter of claim 11, wherein the level of radiation delivered by the radiation source wire (51) is in the range of about 20 to 3000 rads over a period of no less than two minutes.
Claim 13
Dependent Claim
40 words
The catheter of any of claims 1 to 3, wherein the expandable region (12) is configured to center the radiation source wire within the body lumen so that substantially equal amounts of radiation energy are directed to the body lumen.
Claim 14
Dependent Claim
39 words
The catheter of claim 13, wherein the expandable region has a plurality of expandable members (12) disposed along the distal end of the elongated catheter body (11) to further center the radiation source wire (51) in the body lumen.
Claim 15
Dependent Claim
33 words
The catheter of any of claims 1 to 3, wherein the blind lumen (50) terminates in the distal end of the elongated catheter body (11) and does not open to the body lumen.
Claim 16
Dependent Claim
28 words
The catheter of any of claims 1 to 3, wherein the elongated catheter body is formed of a relatively stiff proximal section and a substantially flexible distal end.
Claim 17
Dependent Claim
36 words
The catheter of any of claims 1 to 3, wherein the proximal end of the elongated catheter body has a guide wire port (23) for receiving a guide wire (24) for over-the-wire delivery of the catheter.
Claim 18
Dependent Claim
45 words
The catheter of any of claims 1 to 3, wherein a guide wire port (21) for receiving a guide wire is disposed in a sidewall (22) of the catheter so that the catheter can be rapidly exchanged when it is withdrawn from the body lumen.
Claim 19
Dependent Claim
48 words
The catheter of claim 18, wherein a slit (25) is formed in the sidewall (22) of the elongated catheter body from the guide wire port (21) toward the distal end of the elongated catheter body (11) to facilitate rapid exchange upon withdrawing the catheter from the body lumen.
Claim 20
Dependent Claim
186 words
An intravascular catheter (10) for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen, comprising: an elongated catheter body (11) having a proximal end and a distal end; an expandable region (12) disposed at the distal end of the elongated catheter body, the expandable region having a proximal end (14) and a distal end (15); a guide wire lumen (20) extending through the elongated catheter body from the proximal end to the distal end for receiving a guide wire (24); a control wire lumen (17) disposed in the elongated catheter body and extending from the proximal end to the expandable region, the control wire lumen adapted to receive a control wire (13) for effecting axial movement of the expandable region; and the expandable region having the radiation source (52) associated therewith so that the control wire can be moved axially to expand the expandable region into contact with the body lumen and provide perfusion of blood through the expandable region while the radiation source is being exposed to the body lumen.
Claim 21
Dependent Claim
37 words
The catheter of any of claims 1 to 3, wherein the radiation source wire (51) includes a radiation source (52) taken from the group of radiation sources having a half life of less than one hundred days.
Claim 22
Dependent Claim
34 words
The catheter of claim 20 or 21, wherein the radiation source (52) is taken from the group including iridium 192 , cobalt 60 , vanadium 48 , gold 198 , and phosphorus 32 .
Claim 23
Dependent Claim
21 words
The catheter of claim 21 or claim 22, wherein the group of radiation sources (52) includes alpha-, beta- and gamma-emitting radiation.
Claim 24
Dependent Claim
31 words
The catheter of any of claims 1, 2, 3 or 20 wherein the body lumen is a coronary artery and the catheter is sized for intraluminal delivery into the coronary artery.
Claim 25
Dependent Claim
20 words
The catheter of claim 20, wherein at least a portion of the expandable region is formed from the radiation source.
Claim 26
Dependent Claim
20 words
The catheter of claim 20, wherein at least a portion of the expandable region is impregnated with the radiation source.
Claim 27
Dependent Claim
20 words
The catheter of claim 20, wherein at least a portion of the expandable region is coated with the radiation source.
Claim 28
Dependent Claim
38 words
The catheter of claim 20, wherein at least a portion of the expandable region is formed from a metal alloy taken from the group of metal alloys including stainless steel, tungsten, gold, palladium, platinum, tantalum, iridium, and nickel-titanium.
Claim 29
Dependent Claim
20 words
The catheter of claim 20, wherein at least a portion of the expandable region is formed from a polymeric material.
Claim 30
Dependent Claim
23 words
The catheter of claim 29, wherein the polymeric material is taken from the group of polymeric materials including polyethylene, polyethylene teraphthalate, and nylon.
Claim 31
Independent Claim
269 words
A method for maintaining the patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen, comprising: a) providing a catheter having: an elongated catheter body (11) having a proximal end and a distal end; an expandable region (12) disposed at the distal end of the elongated catheter body, the expandable region having a proximal end (14) and a distal end (15); a guide wire lumen (20) extending through the elongated catheter body from the proximal end to the distal end for receiving a guide wire (24); means for expanding and contracting the expandable region; and a blind lumen (50) disposed in the elongated catheter body and extending from the proximal end and terminating at a position near the distal end (15) of the expandable region, the blind lumen adapted to receive a radiation source wire (51); b) positioning the guide wire in the body lumen; c) advancing the catheter over the guide wire by inserting the guide wire in the distal end of the catheter and into the guide wire lumen; d) advancing the elongated catheter body over the guide wire until the expandable region is positioned in the body lumen; e) expanding the expandable region into contact with the body lumen; f) centering the blind lumen in the body lumen; g) perfusing blood flow through the expandable region; h) inserting the radiation source wire in the blind lumen for delivering a radiation dose to the body lumen; i) contracting the expandable region; and j) withdrawing the catheter and the radiation source wire from the body lumen.
References Cited (Backward Citations)
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