EP0664125A1
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EP
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Inhibition of myeloperoxidase activity
Assignee: Eli Lilly and Co
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Filing: 1994-12-19
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Granted: —
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Expires: 2014-12-19
Abstract
Abstract A method of inhibiting myeloperoxidase activity or a physiological condition associated with an excess thereof, comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R¹ and R³ are independently hydrogen, -CH₃, wherein Ar is optionally substituted phenyl; R² is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Inventors
- 👤 Andrew Lawrence Glasebrook
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 03:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K31/40; A61K31/4025; A61K31/435; A61K31/44; A61K31/445; A61K31/4523; A61K31/4535; A61P; A61P13/00; A61P13/02; A61P15/00; A61P29/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C; C07; C07D; C07D409/00; C07D409/02; C07D409/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
53 words
The use of a compound having the formula wherein R¹ and R³ are independently hydrogen. -CH₃, or wherein Ar is optionally substituted phenyl; R² is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof, in the preparation of a medicament useful for inhibiting myeloperoxidase activity.
Claim 2
Dependent Claim
13 words
The use of Claim 1 wherein said compound is the hydrochloride salt thereof.
Claim 3
Dependent Claim
10 words
The use of Claim 1 wherein said medicament is prophylactic.
Claim 4
Dependent Claim
13 words
The use of Claim 1 wherein said compound is or its hydrochloride salt.
Claim 5
Dependent Claim
60 words
The use of a compound having the formula wherein R¹ and R³ are independently hydrogen, -CH₃, or wherein Ar is optionally substituted phenyl; R² is selected from the group consisting of pyrrolidino and piperidino; or a pharmaceutically acceptable salt or solvate thereof, in the preparation of a medicament useful for inhibiting a physiological disorder associated with an excess of myeloperoxidase.
Claim 6
Dependent Claim
13 words
The use of Claim 5 wherein said compound is the hydrochloride salt thereof.
Claim 7
Dependent Claim
10 words
The use of Claim 5 wherein said medicament is prophylactic.
Claim 8
Dependent Claim
13 words
The use of Claim 5 wherein said compound is or its hydrochloride salt.
Claim 9
Dependent Claim
27 words
The use of Claim 5 wherein said disorder is selected from systemic lupus erythrematosas, Hashimoto's thyroiditis, myasthenia gravis, rheumatoid arthritis, multiple sclerosis, Guillan Barre syndrome, or glomerulonephritis.
References Cited (Backward Citations)
US5075321A
Cited
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