Patent US4504519A successfully refreshed from Google Patents.
EP0645149A1
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Absorbable structures for ligament and tendon repair
Assignee: Ethicon Inc
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Filing: 1994-09-28
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Granted: —
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Expires: 2014-09-28
Abstract
Abstract A fully absorbable prosthesis (1) for the repair of damaged ligaments and/or tendons in the form of a multilayer spiral roll comprising the following spiral layers: a foraminous layer (2) of a synthetic bioabsorbable material; a bioabsorbable film (3); and a layer (4) of a bioabsorbable biopolymer sponge. The invention also provides a method of making such a prosthesis, comprising the steps of: providing a laminate of a foraminous layer of bioabsorbable material and a bioabsorbable film; coating the laminate with a layer of an aqueous gel comprising a bioabsorbable polymer; rolling up the laminate and the gel layer into a spiral roll, followed by drying the gel to form a layer of bioabsorbable sponge. The foraminous layer (2) preferably comprises a synthetic bioabsorbable polymer having high tensile strength. The bioabsorbable film (3) and sponge layer (4) preferably comprise a chemotactic biopolymer such as collagen.
Inventors
- 👤 Nicholas D. Light
- 👤 James Mcgregor
- 👤 Wilson Harvey
- 👤 Paul W. Watt
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:47
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/08; A61B; A61B17/00; A61B17/11; A61B17/1146; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61L27/58; A61B2017/00004; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30064; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30291; A61F2002/30293; A61F2/3094; A61F2002/30971; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2230/0091; A61F2240/00; A61F2240/001; A61L2430/00; A61L2430/10; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
37 words
A bioabsorbable ligament or tendon prosthesis in the form of a multilayered spiral roll comprising the following spiral layers: a foraminous layer of a synthetic bioabsorbable material; a bioabsorbable film, and a layer of a bioabsorbable sponge.
Claim 2
Dependent Claim
21 words
A bioabsorbable prosthesis according to claim 1, wherein the diameter of the multilayered spiral roll is from 1.2 to 21 mm.
Claim 3
Dependent Claim
47 words
A bioabsorbable prosthesis according to claim 1 or 2, wherein the foraminous layer comprises a polymer or copolymer of lactic acid and/or glycolic acid, oxidised regenerated cellulose, polydioxanone (PDS), a copolymer of lactic acid and ε-caprolactam, polyhydroxybutyric acid or a copolymer of hydroxybutyric acid and hydroxyvaleric acid.
Claim 4
Dependent Claim
25 words
A bioabsorbable prosthesis according to claim 1, 2 or 3, wherein the foraminous layer is embedded in the bioabsorbable film or in the sponge layer.
Claim 5
Dependent Claim
24 words
A bioabsorbable prosthesis according to any preceding claim wherein the maximum thickness of the foraminous layer is in the range 0.02 to 0.3 mm.
Claim 6
Dependent Claim
21 words
A bioabsorbable prosthesis according to any preceding claim, wherein the bioabsorbable film comprises a biopolymer or a chemically cross-linked biopolymer derivative.
Claim 7
Dependent Claim
15 words
A bioabsorbable prosthesis according to claim 6, wherein the biopolymer comprises collagen or a glycosaminoglycan.
Claim 8
Dependent Claim
17 words
A bioabsorbable prosthesis according to any preceding claim, wherein oil microdroplets are dispersed in the bioabsorbable film.
Claim 9
Dependent Claim
30 words
A bioabsorbable prosthesis according to claim 8, wherein the oil is present in an amount of from 1% to 90% by weight, based on the weight of the bioabsorbable film.
Claim 10
Dependent Claim
23 words
A bioabsorbable prosthesis according to any preceding claim, wherein the thickness of the bioabsorbable film is in the range 0.01 to 0.1 mm.
Claim 11
Dependent Claim
21 words
A bioabsorbable prosthesis according to any preceding claim, wherein the bioabsorbable sponge comprises a biopolymer or a chemically cross-linked biopolymer derivative.
Claim 12
Dependent Claim
16 words
A bioabsorbable prosthesis according to claim 11, wherein the bioabsorbable sponge comprises collagen or a glycosaminoglycan.
Claim 13
Dependent Claim
20 words
A bioabsorbable prosthesis according to any preceding claim, further comprising microdroplets of a bioabsorbable oil dispersed in the bioabsorbable sponge.
Claim 14
Dependent Claim
32 words
A bioabsorbable prosthesis according to claim 13, wherein the bioabsorbable oil which is present in the amount of from 1% to 90% by weight, based on the weight of the bioabsorbable sponge.
Claim 15
Dependent Claim
24 words
A bioabsorbable prosthesis according to any preceding claim, wherein the thickness of the bioabsorbable sponge layer is in the range 0.5 to 2.5 mm.
Claim 16
Dependent Claim
13 words
A bioabsorbable prosthesis substantially as hereinbefore described with reference to the Figure 1.
Claim 17
Dependent Claim
26 words
Use of a bioabsorbable prosthesis according to any preceding claim for the preparation of a surgical implant for the repair of a damaged tendon or ligament.
Claim 18
Independent Claim
76 words
A method of making a bioabsorbable prosthesis for use in surgical repair of a damaged ligament or tendon, the method comprising the steps of: providing a laminate of a foraminous layer of bioabsorbable material and a bioabsorbable film; coating the laminate with a layer of an aqueous gel comprising a bioabsorbable polymer; rolling up the laminate and the gel layer into a spiral roll, followed by drying the gel to form a layer of bioabsorbable sponge.
Claim 19
Dependent Claim
29 words
A method of making a bioabsorbable prosthesis according to claim 18, wherein the said step of rolling up comprises rolling up through between 2 and 6 complete 360° revolutions.
Claim 20
Dependent Claim
42 words
A method of making a bioabsorbable prosthesis according to claim 18 or 19, wherein the step of providing a bioabsorbable film comprises the steps of: providing a layer of an aqueous solution or suspension of bioabsorbable material, and drying the said layer.
Claim 21
Dependent Claim
59 words
A method of making a bioabsorbable prosthesis according to claim 20, wherein the said layer of an aqueous solution or suspension of the bioabsorbable material is coated onto the foraminous layer of a synthetic bioabsorbable material, or wherein the layer of a synthetic bioabsorbable material is immersed in the layer of an aqueous solution or suspension of bioabsorbable material.
Claim 22
Dependent Claim
31 words
A method of making a bioabsorbable prosthesis according to claim 20 or 21, further comprising the steps of emulsifying a bioabsorbable oil in said aqueous solution or suspension of bioabsorbable material.
Claim 23
Independent Claim
22 words
A method of making a bioabsorbable prosthesis according to any of claims 18 to 22, wherein the aqueous gel comprises acid-swollen collagen.
Claim 24
Independent Claim
28 words
A method of making a bioabsorbable prosthesis according to any of claims 18 to 23, further comprising the step of emulsifying a bioabsorbable oil in the aqueous gel.
Claim 25
Independent Claim
46 words
A method of making a bioabsorbable prosthesis according to any of claims 18 to 24, wherein the step of drying the gel to form a bioabsorbable sponge comprises the steps of freezing the gel, followed by freeze-drying the gel by evaporation of water under reduced pressure.
Claim 26
Independent Claim
41 words
A method of making a bioabsorbable prosthesis according to any of claims 18 to 25, wherein the step of drying the gel to form a bioabsorbable sponge comprises the steps of freezing the gel, followed by solvent drying the frozen gel.
Claim 27
Independent Claim
16 words
A method of making a bioabsorbable prosthesis substantially as hereinbefore described with reference to the Examples.
References Cited (Backward Citations)
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