EP0525475A2
Expired / Lapsed
EP
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A beta-blocker and carbachol containing antiglaucoma composition
Assignee: Alcon Vision LLC
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Filing: 1992-07-10
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Granted: —
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Expires: 2012-07-10
Abstract
Abstract Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker to reduce the production of aqueous humor and carbachol to enhance the outflow of aqueous humor. A method of controlling elevated intraocular pressure with those compositions is also described.
Inventors
- 👤 Louis Desantis, Jr.
- 👤 Rajni Jani
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 22:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/21; A61K31/27; A61K31/335; A61K31/34; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/435; A61K31/44; A61K31/445; A61K31/535; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P27/06
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
26 words
A topical ophthalmic composition for the treatment of glaucoma and ocular hypertension, comprising: a beta-blocker, carbachol, an anionic mucomimetic polymer and a finely-divided cation exchange resin.
Claim 2
Dependent Claim
72 words
The composition of claim 1, wherein: the final composition concentration of the beta-blocker is less than or equal to about 2.0 wt%; the final composition concentration of carbachol is less than or equal to about 5.0 wt%; the final composition concentration of the anionic mucomimetic polymer is between about 0.05 and about 8.0 wt%; and the final composition concentration of the cation exchange resin is between about 0.05 and about 10.0 wt%.
Claim 3
Dependent Claim
21 words
The composition of claim 2, wherein the final composition concentration of the beta-blocker is between about 0.1 and about 1.0 wt%.
Claim 4
Dependent Claim
21 words
The composition of claim 3, wherein the final composition concentration of the beta-blocker is between about 0.25 and about 0.5 wt%.
Claim 5
Dependent Claim
16 words
The composition of claim 4, wherein the final composition concentration of the beta-blocker is 0.25 wt%.
Claim 6
Dependent Claim
20 words
The composition of claim 2, wherein the final composition concentration of carbachol is between about 0.25 and about 3.0 wt%.
Claim 7
Dependent Claim
15 words
The composition of claim 6, wherein the final composition concentration of carbachol is 0.75 wt%.
Claim 8
Dependent Claim
15 words
The composition of claim 6, wherein the final composition concentration of carbachol is 1.5 wt%.
Claim 9
Dependent Claim
15 words
The composition of claim 6, wherein the final composition concentration of carbachol is 3.0 wt%.
Claim 10
Dependent Claim
60 words
The composition of claim 2, wherein the beta-blocker is selected from the racemic and enantiomeric forms of: betaxolol, timolol, metoprolol, befunolol, falintolol, levobunolol, carteolol, mepindolol, pindolol, bisoprolol, bopindolol, atenolol, arotinolol, acebutolol, nadolol, celiprolol, metipranolol, bevantolol, ICI 118,551, pamatolol, penbutolol, toliprolol, tiprenolol, practololm procinolol, exaprolol, cicloprolol, carazolol, tazolol, tienoxolol, oxprenolol, propranolol, IPS 329, labetolol, dilevalol, esmolol, bupranolol, bunolol, isoxaprolol and diacetolol.
Claim 11
Dependent Claim
10 words
The composition of claim 10, wherein the beta-blocker is betaxolol.
Claim 12
Dependent Claim
25 words
The composition of claim 11, wherein the final composition concentration of betaxolol is 0.25 wt% and the final composition concentration of carbachol is 0.75 wt%.
Claim 13
Dependent Claim
25 words
The composition of claim 11, wherein the final composition concentration of betaxolol is 0.25 wt% and the final composition concentration of carbachol is 1.5 wt%.
Claim 14
Dependent Claim
25 words
The composition of claim 11, wherein the final composition concentration of betaxolol is 0.25 wt% and the final composition concentration of carbachol is 3.0 wt%.
References Cited (Backward Citations)
No citation records indexed.
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