EP0475077A2
Expired / Lapsed
EP
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Bone regeneration membrane
Assignee: AO Technology AG
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Filing: 1991-08-07
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Granted: —
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Expires: 2011-08-07
Abstract
Abstract A bone regeneration membrane containing resorbable or degradable, polymeric and/or polymeric-ceramic material with a glass transition temperature in the range of -30 DEG to + 200 DEG C. The novel membrane can be used for the spontaneous regeneration of bone and for the improved application of autologous or allogenic graft materials and therapeutic agents. <IMAGE>
Inventors
- 👤 Sylwester Gogolewski
- 👤 Stephan M. Perren
- 👤 Richard M. Meinig
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:21
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/80; A61B17/8085; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2846; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L31/04; A61L31/06; A61L31/12; A61L31/125; A61L31/127; A61L31/16; C; C08; C08L; C08L5/00; C08L67/00; C08L67/04; C08L73/00; C08L73/02; C08L79/00; C08L79/02; C08L89/00; A61B17/60; A61B17/64; A61B17/84; A61B17/842; A61B2017/00831; A61B2017/00867; A61F2/0077; A61F2/30; A61F2/30767; A61F2/3094; A61F2/30965; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30092; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2002/30291; A61F2002/30293; A61F2002/30316; A61F2002/30329; A61F2002/30462; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0014; A61F2220/00; A61F2220/0025; A61F2220/0075; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2230/0091; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
39 words
A bone regeneration membrane comprising resorbable or degradable polymeric and/or polymeric-ceramic material, characterized in that the glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of -30 to + 200°C, said membrane having micropores therein.
Claim 2
Dependent Claim
33 words
A membrane according to claim 1, characterized in that said glass transition temperature of said polymeric and/or polymeric-ceramic material is in the range of +10° to + 90°C, preferably between +30 to +70°C.
Claim 3
Dependent Claim
43 words
A membrane according to claim 1 or 2, characterized in that at least 90 percent of said micropores have a diameter below 500 µm, preferably in the range of 0.01 to 50.0 µm, most preferably in the range of 0.1 to 5 µm.
Claim 4
Dependent Claim
18 words
A membrane according to one of the claims 1 to 3, characterized in that said micropores are interconnected.
Claim 5
Dependent Claim
40 words
A membrane according to one of the claims 1 to 4, characterized in that at least 90 weight percent, preferably 99 weight percent of said polymeric and/or polymeric-ceramic material has a molecular weight in the range of 5'000 to 1'000'000.
Claim 6
Dependent Claim
23 words
A membrane according to one of the claims 1 to 5, characterized in that it further comprises reinforcement including resorbable and/or degradable fibers.
Claim 7
Dependent Claim
37 words
A membrane according to one of the claims 1 to 6, characterized in that it has a thickness of between 0,05 to 5,0 mm, preferably between 0,2 to 3,0 mm, most preferably between 0,4 to 1,5 mm.
Claim 8
Dependent Claim
42 words
A membrane according to one of the claims 1 to 7, characterized in that at least 90 weight percent of said polymeric material has a molecular weight in the range of 25'000 to 150'000, preferably in the range of 30'000 to 70'000.
Claim 9
Dependent Claim
35 words
A membrane according to one of the claims 1 to 8, characterized in that said polymeric material comprises highly purified polyhydroxyacids, polysaccharides, polyamines, polyaminoacids, polyorthoesters, polyanhydrides, collagen or composites thereof with tricalcium phosphate and/or hydroxyapatite.
Claim 10
Dependent Claim
19 words
A membrane according to one of the claims 1 to 9, characterized in that it further contains antibiotic agents.
Claim 11
Dependent Claim
19 words
A membrane according to one of the claims 1 to 10, characterized in that it further contains antiosteomyelitis agents.
Claim 12
Dependent Claim
19 words
A membrane according to one of the claims 1 to 11, characterized in that it further contains antineoplastic agents.
Claim 13
Dependent Claim
26 words
A membrane according to one of the claims 1 to 12, characterized in that it further contains osteoconductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 14
Dependent Claim
26 words
A membrane according to one of the claims 1 to 13, characterized in that it further contains osteoinductive agents of autogenic, allogenic, xenogenic, or synthetic origin.
Claim 15
Dependent Claim
23 words
A membrane according to one of the claims 1 to 14, characterized in that it has a curved surface, preferably a rectilinear surface.
Claim 16
Dependent Claim
20 words
A membrane according to claim 15, characterized in that said rectilinear surface is an adaptable surface, preferably a cylindrical surface.
Claim 17
Dependent Claim
19 words
A membrane according to one of the claims 1 to 16, characterized in that it has a shape memory.
Claim 18
Dependent Claim
26 words
A membrane according to one of the claims 1 to 16 characterized in that it is formable into a tubular form, preferably with a longitudinal slit.
Claim 19
Dependent Claim
31 words
A membrane according to claim 18, characterized in that it is adapted to form semi-occlusive fits at the two extremities of the tube formed by said membrane for fixation to bones.
Claim 20
Dependent Claim
30 words
A membrane according to claim 18, characterized in that it has ends shaped to form semi-occlusive fits over cortical bone ends and within medullary canals of long or tubular bones.
Claim 21
Dependent Claim
19 words
A membrane according to claim 18 , characterized in that it comprises a sheet prefashioned into a tubular form.
Claim 22
Dependent Claim
19 words
A membrane according to claim 18 , characterized in that it is rolled up to form a multilayer tube.
Claim 23
Dependent Claim
39 words
A membrane according to one of the claims 1 to 22, characterized in that said polymeric and/or polymeric-ceramic material has a molecular weight distribution in the range of 1,2 to 100,0, preferably in the range of 1,9 to 2,5.
Claim 24
Dependent Claim
29 words
Use of the membrane according to one of the claims 1 to 23, characterized in that it is used as a tissue separator which promotes and protects osseous regeneration.
Claim 25
Dependent Claim
33 words
Use of the membrane according to one of the claims 1 to 23, characterized in that it is used for the treatment of osseous defects secondary to trauma, infection, neoplasm, or surgical resection.
Claim 26
Dependent Claim
25 words
Use of the membrane according to one of the claims 1 to 23, characterized in that it is used as cortical spacer across bone defects.
Claim 27
Dependent Claim
42 words
Use of the membrane according to one of the claims 1 to 23, characterized in that it is used as an osseous activity barrier that confines bone regeneration to desired regions and prevents the formation of synostosis, physeal bars, or ectopic bone.
Claim 28
Dependent Claim
32 words
Use of the membrane according to one of the claims 1 to 23, characterized in that it is used as a spacer for skeletal resection, revision arthroplasty, or arthrodesis of human joints.
Claim 29
Dependent Claim
23 words
Use of the membrane according to claim 18, characterized in that it is used as a container for autologous or allogenic graft materials.
References Cited (Backward Citations)
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