EP0472205A1
Expired / Lapsed
EP
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Assays using a soluble fibrin-like monomer
Assignee: New York Blood Center
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Filing: 1991-08-23
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Granted: —
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Expires: 2011-08-23
Abstract
Abstract An assay method that requires a soluble fibrin monomer or a soluble fibrin monomer reagent as one of the components of the assay. The reagent is a fibrin-like material having a solubility and stability similar to fibrinogen in that it remains soluble and stable at physiological conditions at a concentration employed in the assay in the absence of fibrin polymerization inhibitors or reagents for maintaining solubility.
Inventors
- 👤 Roman Procyk
- 👤 Bohdan J. Kudryk
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:04
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; C; C12; C12Q; C12Q1/00; C12Q1/56; G01N33/86; G01N2333/00; G01N2333/435; G01N2333/745; G01N2333/75; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/972; G01N2333/9726
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
70 words
In an assay method that requires a soluble fibrin or a soluble fibrin monomer reagent as one of the components of the assay, the improvement wherein the reagent is a fibrin-like material having a solubility and stability similar to fibrinogen in that it remains soluble and stable at physiological conditions at a concentration employed in said assay in the absence of fibrin polymerization inhibitors or reagents for maintaining said solubility.
Claim 2
Dependent Claim
70 words
In an assay method that requires a soluble fibrin or a soluble fibrin monomer reagent as one of the components of the assay, the improvement wherein the reagent is a fibrin-like material having a solubility and stability similar to fibrinogen in that it remains soluble and stable at physiological conditions at a concentration employed in said assay in the absence of fibrin polymerization inhibitors or reagents for maintaining said solubility.
Claim 3
Dependent Claim
14 words
The method of claim 1, wherein the concentration is 0.08 mg/ml to 15 mg/ml.
Claim 4
Dependent Claim
18 words
The method according to claim 1, wherein the assay is for the quantitative determination of soluble fibrin monomers.
Claim 5
Dependent Claim
15 words
The method according to claim 1, wherein the assay is for plasmin activator inhibitor activity.
Claim 6
Dependent Claim
14 words
The method according to claim 1, wherein the assay is for tissue-plasminogen activator activity.
Claim 7
Dependent Claim
12 words
The method according to claim 1, wherein the assay is an immunoassay.
Claim 8
Dependent Claim
24 words
The method according to claim 1, wherein the fibrin-like material remains soluble and stable in physiological buffers at a pH of 3 to 10.
Claim 9
Dependent Claim
34 words
The method according to claim 1, wherein the fibrin-like material remains soluble and stable in physiological buffers at a pH of 3 to 10 and at a concentration of 0.08 mg/ml to 15 mg/ml.
References Cited (Backward Citations)
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