EP0450812A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Antihypercholesterolemics
Assignee: Merck and Co Inc
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Filing: 1991-03-21
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Granted: —
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Expires: 2011-03-21
Abstract
Abstract This invention relates to compounds of structural formula (I): <IMAGE> which are useful for treating hypercholesterolemia and inhibiting fungal growth. <IMAGE>
Inventors
- 👤 James D. Bergstrom
- 👤 Jerrold M. Liesch
- 👤 Otto D. Hensens
- 👤 Janet C. Onishi
- 👤 Leeyuan Huang
- 👤 Frank L. Vanmiddlesworth
- 👤 Maria T. Diez
- 👤 Kenneth F. Bartizal
- 👤 Mary Nallin
- 👤 Walter Rozdilsky
- 👤 Fernando Pelaez Perez
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 23:57
CPC Classifications
C; C12; C12P; C12P1/00; C12P1/02; C07; C07D; C07D493/00; C07D493/02; C07D493/08; A; A01; A01N; A01N43/00; A01N43/90; A61; A61P; A61P3/00; A61P3/06; A61P31/00; A61P31/04; A61P43/00; C12N; C12N1/00; C12N1/14; C12N1/145; C12N9/00; C12N9/10; C12N9/1085; C12P17/00; C12P17/18; C12P17/181; C12P9/00; C12R; C12R2001/00; C12R2001/645
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
71 words
A compound of structural formula I. wherein Z₁, Z₂ and Z₃ are each independently selected from a) H; b) C₁₋₅ alkyl; c) C₁₋₅ alkyl substituted with a member of the group consisting of i) phenyl, ii) phenyl substituted with methyl, methoxy, halogen (Cl, Br, I, F) or hydroxy; or a pharmaceutically acceptable salt of a compound of formula (I) in which at least one of Z₁, Z₂ and Z₃ is hydrogen.
Claim 2
Dependent Claim
14 words
A compound of Claim 1 wherein the relative configuration of structural formula (I) is:
Claim 3
Dependent Claim
20 words
A compound of Claim 2 in which Z₁, Z₂ and Z₃ are each hydrogen or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
A compound of Claim 2 in which Z₁, Z₂ and Z₃ are each methyl.
Claim 5
Dependent Claim
20 words
A pharmaceutical composition comprising a nontoxic therapeutically effective amount of a compound of Claim 1 and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
17 words
The use of a compound of Claim 1 for the manufacture of a medicament for treating hypercholesterolemia.
Claim 7
Dependent Claim
21 words
A culture of MF5453 (ATCC 20986) or an active mutant thereof, capable of producing a compound of structure: in recoverable amounts.
Claim 8
Dependent Claim
31 words
A process of making a compound of structure: comprising cultivating MF5453 (ATCC 20986) or an active mutant thereof, under conditions suitable for the formation of said compound and recovering the compound.
Claim 9
Dependent Claim
38 words
A method for inhibiting fungal growth in soil or plant parts, or in inanimate objects, comprising applying to the area where growth is to be controlled an antifungally effective amount of a compound as claimed in Claim 1.
Claim 10
Dependent Claim
25 words
The use of a compound as claimed in Claim 1 for the manufacture of a medicament suitable for inhibiting fungal growth in a living organism.
Claim 11
Dependent Claim
17 words
The use as claimed in Claim 10 wherein the compound is selected from the group consisting of:
References Cited (Backward Citations)
US4276216A
Cited
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