EP0421419A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
Assignee: Bristol Myers Squibb Co
•
Filing: 1990-10-04
•
Granted: —
•
Expires: 2010-10-04
Abstract
Abstract This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.
Inventors
- 👤 John J. Wright
- 👤 Bradley C. Pearce
- 👤 Rex Parker
- 👤 Asaf A. Quereshi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/352; A61K31/353; A61K31/355; C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D311/70; C07D311/72
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
32 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum cholesterol levels in a bird or a mammal.
Claim 2
Dependent Claim
32 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum cholesterol levels in a bird or a mammal.
Claim 3
Dependent Claim
31 words
The use substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum LDL-cholesterol levels in a bird or a mammal.
Claim 4
Dependent Claim
31 words
The use substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum LDL-cholesterol levels in a bird or a mammal.
Claim 5
Dependent Claim
43 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, the platelet aggregation to ADP, EPI and Collagen in platelet rich plasma and whole blood.
Claim 6
Dependent Claim
43 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, the platelet aggregation to ADP, EPI and Collagen in platelet rich plasma and whole blood.
Claim 7
Dependent Claim
37 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, TXA2 and platelet factor 4 levels providing antithrombotic effectiveness.
Claim 8
Dependent Claim
37 words
The use of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, TXA2 and platelet factor 4 levels providing antithrombotic effectiveness.
Claim 9
Dependent Claim
30 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum cholesterol levels in a bird or a mammal.
Claim 10
Dependent Claim
30 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum cholesterol levels in a bird or a mammal.
Claim 11
Dependent Claim
30 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum LDL-cholesterol levels in a bird or a mammal.
Claim 12
Dependent Claim
30 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for lowering the serum LDL-cholesterol levels in a bird or a mammal.
Claim 13
Dependent Claim
41 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, the platelet aggregation to ADP, EPI and Collagen in platelet rich plasma and whole blood.
Claim 14
Dependent Claim
41 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, the platelet aggregation to ADP, EPI and Collagen in platelet rich plasma and whole blood.
Claim 15
Dependent Claim
35 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, TXA2 and platelet factor 4 levels providing antithrombotic effectiveness.
Claim 16
Dependent Claim
35 words
The use of a prodrug of gamma-tocotrienol, delta-tocotrienol, or tocotrienol, or mixtures thereof, for preparing a pharmaceutical composition for reducing, in a bird or a mammal, TXA2 and platelet factor 4 levels providing antithrombotic effectiveness.
Claim 17
Dependent Claim
15 words
The use of anyone of claims 1 to 8 wherein the tocotrienol is the d-isomer.
Claim 18
Dependent Claim
18 words
The use of anyone of claims 1 to 8 wherein the tocotrienol is the d, l racemic mixture.
Claim 19
Dependent Claim
27 words
A pharmaceutical composition comprising a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol or prodrugs thereof and a pharmaceutical acceptable carrier.
Claim 20
Dependent Claim
27 words
A pharmaceutical composition comprising a safe and effective amount of substantially pure gamma-tocotrienol, substantially pure delta-tocotrienol, substantially pure tocotrienol or prodrugs thereof and a pharmaceutical acceptable carrier.
Claim 21
Dependent Claim
12 words
The pharmaceutical composition of claim 11 wherein the tocotrienol is the d-isomer.
Claim 22
Dependent Claim
13 words
The pharmaceutical composition of claim 11 wherein the tocotrienol is the d,l-racemic mixture.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.