Patent US1841347A successfully refreshed from Google Patents.
EP0364799B1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Cancer treatment
Assignee: Delcath Systems Inc
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Filing: 1989-09-30
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Granted: 1995-05-03
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Expires: 2009-09-30
Abstract
Abstract Perfusing a high concentration of an agent to treat an organ (3), such as anti-cancer agents through a body organ containing a tumor, without their entering the body's general circulation (supplied from syringe (4)), removing them from the organ (3) with effluent blood and transporting the contaminated blood to an extracorporeal circuit (tubing (17), pump (21), detoxification zone (43), tube (44) where the blood is treated to remove the contamination, and returning the treated blood to the body (3). The process prevents toxic levels of the agents from entering the body's general circulation while delivering lethal doses of the agents to the tumor. There are described various apparatus for effecting the intra- and extracorporeal treatment of such contaminated blood.
Inventors
- 👤 William L Bodden
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 00:52
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0067; A61M25/0074; A61M25/0075; A61M1/00; A61M1/36; A61M1/3615; A61M1/3621; A61M25/10; A61M25/1011; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/205; A61M60/216; A61M60/226; A61M60/232; A61M60/30; A61M60/31; A61M60/36; A61M60/37; A61M60/50; A61M60/508; A61M60/515; A61M60/531; A61M60/538; A61M60/554; A61M60/80; A61M60/802; A61M60/818; A61M60/833; A61M60/845; A61M60/849; A61M2025/0001; A61M2025/0003; A61M2025/1043; A61M2025/1052; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/3344; A61M2205/3355
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
262 words
Apparatus for perfusing a high concentration of therapeutic agents through a site in a body organ without their entering the body's general circulation, removing them from the environment of said site with effluent blood, transporting the contaminated effluent blood to an extracorporeal circuit where the blood is treated to remove the contamination, and the treated blood is returned to the body, which comprises an intracorporeal circuit means comprising means for transporting the contaminated blood to means for separating the contamination from the blood and returning the blood to the body, and the intracorporeal circuit means comprising a double balloon catheter (9) connected through tubing (17) into a pump (21) that assists the passage of the contaminated blood to the means (43) for separating the contamination from the blood and a second catheter for returning the blood to the body, characterized in, that the double balloon catheter (9) comprises: a single plastic tube (102) having a cranial end and a caudal end, said plastic tube (102) defining a main lumen (120, 169) for outflowing blood, two balloons (110, 114), fixedly spaced apart about said plastic tube (102) and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube (102), fenestrations (104) in said plastic tube (102) between said balloons (110, 114) to said main lumen (120, 169), at least one further lumen (124, 170) within the plastic tube for effecting inflation or deflation of said balloons (110, 114), the lumens of said plastic tube (102) being closed at the cranial end to any appreciable inflow of blood.
Claim 2
Dependent Claim
262 words
Apparatus for perfusing a high concentration of therapeutic agents through a site in a body organ without their entering the body's general circulation, removing them from the environment of said site with effluent blood, transporting the contaminated effluent blood to an extracorporeal circuit where the blood is treated to remove the contamination, and the treated blood is returned to the body, which comprises an intracorporeal circuit means comprising means for transporting the contaminated blood to means for separating the contamination from the blood and returning the blood to the body, and the intracorporeal circuit means comprising a double balloon catheter (9) connected through tubing (17) into a pump (21) that assists the passage of the contaminated blood to the means (43) for separating the contamination from the blood and a second catheter for returning the blood to the body, characterized in, that the double balloon catheter (9) comprises: a single plastic tube (102) having a cranial end and a caudal end, said plastic tube (102) defining a main lumen (120, 169) for outflowing blood, two balloons (110, 114), fixedly spaced apart about said plastic tube (102) and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube (102), fenestrations (104) in said plastic tube (102) between said balloons (110, 114) to said main lumen (120, 169), at least one further lumen (124, 170) within the plastic tube for effecting inflation or deflation of said balloons (110, 114), the lumens of said plastic tube (102) being closed at the cranial end to any appreciable inflow of blood.
Claim 3
Dependent Claim
46 words
The apparatus of Claim 1 wherein the means for separating the contamination from the blood comprises blood detoxification means (43) including one or more of hemoperfusion, hemodialysis, hemofiltration, hemoadsorbtion through antibodies or biological ligands or molecules able to render them nontoxic, or to clear the blood.
Claim 4
Dependent Claim
20 words
The apparatus of Claim 1 or 2 wherein the means for transporting the contaminated blood comprises a smooth rotator pump.
Claim 5
Dependent Claim
23 words
The apparatus of Claim 1 or 2 wherein the means for transporting the contaminated blood comprises a centrifugal pump having a vane design.
Claim 6
Independent Claim
15 words
The apparatus of any of the preceding claims wherein the extracorporeal circuit possesses pressure monitoring.
Claim 7
Dependent Claim
22 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) the cranial end is tapered.
Claim 8
Dependent Claim
32 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) said plastic tube (102) has a further lumen adapted to accommodate an angiographic guide wire.
Claim 9
Dependent Claim
29 words
Apparatus according to any of the preceding claims, characterized in, that the at least one further lumen connects and is common to the interiors of said balloons (110, 114).
Claim 10
Dependent Claim
31 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) said plastic tube (102) contains an additional lumen (171) adapted to monitor blood pressure.
Claim 11
Dependent Claim
50 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) the length of said plastic tube (102) containing said fenestrations (104) is in the range of up to ten centimeters and said plastic tube (102) has a maximum outside diameter of 24 French.
Claim 12
Dependent Claim
47 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) the caudal end is long enough to extend through the skin of the patient to the outside of the body and terminates in a Luer fitting and a cut-off valve.
Claim 13
Dependent Claim
61 words
Apparatus according to any of the preceding claims, characterized in, that in the double balloon catheter (9) said balloons (110, 114) are spaced apart a distance sufficient to bridge the hepatic veins when said catheter (9) is inserted in the inferior vena cava and said fenestrations (104) are sufficient to remove blood issuing from said hepatic veins without elevating blood pressure.
Claim 14
Dependent Claim
27 words
A disposable kit comprising a double balloon catheter (9), a detoxification means (43), piping and valves to provide an apparatus according to any of the preceding claims.
Claim 15
Dependent Claim
21 words
The kit of Claim 13 comprising one or more of guidewires, heparin, pressure monitoring device and the capacity to add medication.
Claim 16
Dependent Claim
183 words
The kit according to Claims 13 or 14 for removing a treating agent from blood perfused through a body organ of a patient, comprising: a catheter (9) for isolating and removing the blood issuing from said body organ and containing said treating agent; a detoxification means (43) for treating said blood so removed to remove said treating agent; and return catheter means for returning the blood so treated to said patient; said catheter (9) comprising: a single plastic tube (102) having a cranial end and a caudal end, said plastic tube (102) defining a main lumen for outflowing blood, two balloons (110, 114), fixedly spaced apart about said plastic tube (104) and bonded thereto for inflation therabout, one being contiguous to the cranial end of said plastic tube (102), fenestrations (104) in said plastic tube (102) between said balloons (110, 114) to said main lumen (120, 169), at least one further lumen (124, 170) for effecting inflation or deflation of said balloons (110, 114), the lumens of said plastic tube (102) being closed at the cranial end to any appreciable inflow of blood.
Claim 17
Dependent Claim
24 words
The kit of Claim 15 wherein said kit is effective for a treatment selected from the group consisting of hemoperfusion, hemodialysis, hemofiltration and hemoabsorption.
Claim 18
Dependent Claim
57 words
The kit of Claim 15 wherein said return catheter fits within said plastic tube (102) and said lumen of said plastic tube tapers to fit thereabout such that the treated blood is returned past the cranial balloon and said kit includes arterial injection means for introducing said treating agent into an artery leading to said body organ.
Claim 19
Dependent Claim
20 words
The kit of Claim 15 wherein said body organ is the liver and said treating agent is an anti-cancer agent.
Claim 20
Dependent Claim
26 words
The kit of Claim 15 including, in addition, an angiographic guide wire and said cranial end is tapered to the caliber of said angiographic guide wire.
Claim 21
Dependent Claim
153 words
A catheter (9) adapted for percutaneous insertion into a vein or artery for the use in an apparatus according to any of Claims 1 to 12 as well as in a kit according to any of Claims 13 to 19, comprising: a single plastic tube (102) having a cranial end and a caudal end, said plastic tube (102) defining a main lumen for outflowing blood, two balloons (110, 114), fixedly spaced apart about said plastic tube (104) and bonded thereto for inflation thereabout, one being contiguous to the cranial end of said plastic tube (102), fenestrations (104) in said plastic tube (102) between said balloons (110, 114) to said main lumen (120, 169), at least one further lumen (124, 170) within said plastic tube for effecting inflation or deflation of said balloons (110, 114), the lumens of said plastic tube (102) being closed at the cranial end to any appreciable inflow of blood.
References Cited (Backward Citations)
US28742A
Cited
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