EP0361928A2
Expired / Lapsed
EP
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Emulsified composition
Assignee: Shiseido Co Ltd
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Filing: 1989-09-28
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Granted: —
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Expires: 2009-09-28
Abstract
Abstract An emulsified composition having an average particle size of 0.010 to 0.070 µm contains at least the following components (A), (B) and (C): (A) a lipid-soluble drug and a lipid; (B) glycerol and water; (C) a phospholipid and/or a water-soluble nonionic surfactant having a molecular weight of 1000 or more; with (A)/(C) being 0.5/1 to 5/1 (weight ratio).
Inventors
- 👤 Hideo C/O Shiseido Laboratories Nakajima
- 👤 Miyuki C/O Shiseido Laboratories Kohchi
- 👤 Satoshi C/O Shiseido Laboratories Tomomasa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 17:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/734; Y10S977/735; Y10S977/737; Y10S977/738; Y10S977/788; Y10S977/797; Y10S977/798; Y10S977/799; Y10S977/801; Y10S977/84; Y10S977/895; Y10S977/902; Y10S977/904; Y10S977/915
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
68 words
An emulsified composition having an average particle size of 0.010 to 0.070 µm and comprising at least the following components (A), (B) and (C); (A) a lipid-soluble drug and a lipid; (B) glycerol and water; (C) at least one component selected from the group consisting of phospholipids and water-soluble nonionic surfactants having a molecular weight of 1000 or more, the weight ratio of (A)/(C) being 0.5/1 to 5/1.
Claim 2
Dependent Claim
68 words
An emulsified composition having an average particle size of 0.010 to 0.070 µm and comprising at least the following components (A), (B) and (C); (A) a lipid-soluble drug and a lipid; (B) glycerol and water; (C) at least one component selected from the group consisting of phospholipids and water-soluble nonionic surfactants having a molecular weight of 1000 or more, the weight ratio of (A)/(C) being 0.5/1 to 5/1.
Claim 3
Dependent Claim
24 words
An emulsified composition as claimed in claim 1, wherein the weight ratio of glycerol/water in the component (B) during emulsification is 3/7 to 9/1.
Claim 4
Dependent Claim
30 words
An emulsified composition as claimed in claim 1 or 2, wherein the component (C) comprises a phospholipid and a water-soluble nonionic surfactant at a weight ratio of 9.5/0.5 to 1/9.
Claim 5
Dependent Claim
47 words
An emulsified composition as claimed in any of claims 1 to 3, wherein the contents of the components (A), (B) and (C) are 1 to 40% by weight, 40 to 95% by weight and 0.5 to 20% by weight, respectively, based on the weight of the composition.
Claim 6
Dependent Claim
31 words
An emulsified composition as claimed in any of claims 1 to 4, wherein the content of the lipid-soluble drug in the component (A) is 1 x 10⁻⁶% to 99.9% by weight.
Claim 7
Dependent Claim
22 words
An emulsified composition as claimed in any of claims 1 to 5, wherein the weight ratio of (A)/(C) is 1/1 to 3/1.
Claim 8
Dependent Claim
37 words
An emulsified composition as claimed in any of claims 1 to 6, wherein the emulsification has been carried out in a high-pressure homogeniser or sonication emulsifying machine and the average particle size is 0.01 to 0.05 µm.
Claim 9
Dependent Claim
62 words
An emulsified composition as claimed in any of claims 1 to 7, wherein component (A) comprises a mono-, di-, or tri-glyceride having more than 33 carbon atoms or a mono-, di-, or tri-glyceride monoester having more than 22 carbon atoms as lipid and an antitumor agent or antifungal agent or non-steroidal antiphlogistic or hormone agent or vitamin dissolved therein as lipid-soluble drug.
References Cited (Backward Citations)
No citation records indexed.
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