EP0360452A2
Expired / Lapsed
EP
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Latex particles in analytical reagents, elements and methods
Assignee: Eastman Kodak Co
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Filing: 1989-09-05
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Granted: —
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Expires: 2009-09-05
Abstract
Abstract There is disclosed a method of making a latex comprising an aqueous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having benzaldehyde groups on the surfaces thereof wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units. The method comprises the step of reacting a polymer having recurring vinylbenzylic halide units with an alkali nitroalkanenitronate and an alkoxide in the presence of water and a water-miscible organic solvent. The polymeric particles of the latex are useful in immunoassays.
Inventors
- 👤 Abraham C/O Eastman Kodak Company Warshawsky
- 👤 Marsha Denise C/O Eastman Kodak Company Bale
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 07:55
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/26; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
69 words
A method of making a latex comprising an aqueous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having aldehyde groups on the surfaces thereof; wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units, characterized in that a polymer having recurring vinylbenzylic halide units with an alkali nitroalkanenitronate is reacted with an alkoxide in the presence of water and a water-miscible organic solvent.
Claim 2
Independent Claim
69 words
A method of making a latex comprising an aqueous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having aldehyde groups on the surfaces thereof; wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units, characterized in that a polymer having recurring vinylbenzylic halide units with an alkali nitroalkanenitronate is reacted with an alkoxide in the presence of water and a water-miscible organic solvent.
Claim 3
Dependent Claim
42 words
A latex composition characterized in that it comprises an aqueous continuous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having aldehyde groups on the surfaces thereof; wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units.
Claim 4
Dependent Claim
42 words
A latex composition characterized in that it comprises an aqueous continuous phase having dispersed therein non-porous monodisperse surfactant-free polymeric particles having aldehyde groups on the surfaces thereof; wherein the polymer particles comprise from 5 to 100 weight percent of recurring benzaldehyde units.
Claim 5
Dependent Claim
99 words
The composition of claim 2 wherein the polymer of the particles is represented by the formula: (̵A x )̵(̵B)̵ y (̵C)̵ z - wherein A represents recurring units derived from one or more hydrophobic ethylenically unsaturated monomers, B represents recurring units derived from an ethylenically unsaturated monomer having the formula: C represents recurring units derived from one or more ethylenically unsaturated monomers other than those represented by A or B; and x is from 0 to about 95 weight percent, y is from 5 to about 100 weight percent, and z is from 0 to about 20 weight percent.
Claim 6
Dependent Claim
17 words
The composition of claim 3 wherein the polymer particles range in size from 0.1 to 3.0 u.m.
Claim 7
Dependent Claim
22 words
The composition of claim 3 wherein the polymer is selected from the group consisting of poly-(vinylbenzaldehyde), poly(vinylbenzaldehyde-co-vinylbenzyi chloride), poly(styrene-co-vinylbenzaldehyde), and poly(styrene-co-vinylbenzaldehyde-co-vinylbenzyl chloride).
Claim 8
Dependent Claim
57 words
A reagent comprising: (a) non-porous surfactant-free polymeric particles having benzaldehyde groups on the surface thereof and the polymeric particles comprising from 5 to 100 weight percent recurring benzaldehyde units; and the particles are covalently attached through the aldehyde groups to (b) an immunological species which is capable of participating in an immunological reaction with a corresponding receptor.
Claim 9
Dependent Claim
57 words
A reagent comprising: (a) non-porous surfactant-free polymeric particles having benzaldehyde groups on the surface thereof and the polymeric particles comprising from 5 to 100 weight percent recurring benzaldehyde units; and the particles are covalently attached through the aldehyde groups to (b) an immunological species which is capable of participating in an immunological reaction with a corresponding receptor.
Claim 10
Dependent Claim
16 words
The reagent of claim 6 wherein said immunological species is an enzyme, drug, antibiotic or antibody.
Claim 11
Dependent Claim
93 words
The reagent of claim 6 wherein the polymer has the formula: (̵A)̵ x (̵B)̵ y (̵C)̵ z wherein A represents recurring units derived from one or more hydrophobic ethylenically unsaturated monomers, B represents recurring units derived from an ethylenically unsaturated monomer having the formula: C represents recurring units derived from one or more ethylenically unsaturated monomers other than those represented by A or B; and x is from 0 to about 95 weight percent, y is from about 5 to 100 weight percent, and z is from 0 to about 20 weight percent.
Claim 12
Dependent Claim
11 words
The reagent of claim 6 wherein the polymer is poly(styrene-co-vinylbenzaldehyde-co-vinylbenzyl chloride).
Claim 13
Dependent Claim
16 words
The reagent of claim 9 wherein the polymer particle size is from 0.1 to 3.0 µm.
Claim 14
Dependent Claim
25 words
The reagent of claim 6 wherein the antibody is selected from antibodies directed against digoxin, phenytoin, phenobarbital, thyroxine, triiodothyronine, gentamicin, carbamazepine, primidone, tobramycin or theophylline.
Claim 15
Dependent Claim
34 words
An analytical element comprising an absorbent carrier material having one or more zones, and containing in one or more of said zones a reagent according to claims 6, 7, 8, 9, 10 and 11.
References Cited (Backward Citations)
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