EP0287074A2
Expired / Lapsed
EP
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Disinfecting compositions
Assignee: Alcide Corp
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Filing: 1988-04-13
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Granted: —
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Expires: 2008-04-13
Abstract
Abstract There is disclosed, in one aspect, a composition for forming a protective barrier while disinfecting substrates such as human or animal skin. The composition comprises two gels adapted to be simultaneously applied and mixed in situ and to adhere onto the substrate. The first gel comprises an aqueous solution containing suitable amounts of a protic acid, preferably lactic acid. The second gel comprises an amount of a metal chlorite, such as sodium chlorite, such that the chlorite ion concentration in the form of chlorous acid in the combined gels is no more than about 15% by weight of the total amount of chlorite ion concentration. The second gel also contains a polysulfonic acid salt. The anion of that salt has the formula: wherein X has a value such that the molecular weight of the anionic portion of the polymer is from about 1,000,000 to about 5,000,000. In another aspect, there is disclosed a method for treating skin diseases. This method comprises applying to the skin an effective amount of the above-noted composition and for low concentration chlorous acid-generating compositions useful for oral hygiene. The compositions are effective oral disinfectants which do not have the strong unpleasant taste of chlorine and are useful in reducing plaque. The invention also concerns processes for making the inventive compositions and methods for using the same.
Inventors
- 👤 Robert D. Kross
- 👤 Carol A. Zamojcin
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:26
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/04; A61K8/042; A01; A01N; A01N25/00; A01N25/02; A01N25/04; A01N25/24; A01N59/00; A61K33/00; A61K33/20; A61K8/18; A61K8/19; A61K8/20; A61K8/30; A61K8/33; A61K8/36; A61K8/362; A61K8/365; A61K8/368; A61K8/72; A61K8/73; A61K8/731; A61K8/81; A61K8/8141; A61K8/8158; A61K9/00; A61K9/0012; A61K9/0041; A61Q; A61Q11/00; A61Q17/00; A61Q17/005; A61K2800/00; A61K2800/80; A61K2800/88
Claims Analysis
Total Claims: 45
Claim 1
Independent Claim
127 words
A composition for disinfecting substrates and forming a protective barrier comprising two gels adapted to be mixed and applied so as to adhere onto said substrate, said first gel comprising an aqueous solution containing suitable amounts of a protic acid, and said second gel comprising an amount of metal chlorite such that, when the gels are combined, the chlorite ion concentration is the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration and wherein said second gel also contains a polysulfonic acid salt wherein the anion of said salt has the formula: wherein X has a value such that the molecular weight of the anionic portion of the polymer is from about 1,000,000 to about 5,000,000.
Claim 2
Dependent Claim
127 words
A composition for disinfecting substrates and forming a protective barrier comprising two gels adapted to be mixed and applied so as to adhere onto said substrate, said first gel comprising an aqueous solution containing suitable amounts of a protic acid, and said second gel comprising an amount of metal chlorite such that, when the gels are combined, the chlorite ion concentration is the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration and wherein said second gel also contains a polysulfonic acid salt wherein the anion of said salt has the formula: wherein X has a value such that the molecular weight of the anionic portion of the polymer is from about 1,000,000 to about 5,000,000.
Claim 3
Dependent Claim
30 words
The composition of claim 1 wherein said composition of the second gel comprises from about 5% to about 15% of solid polysulfonic acid salt by weight of the total composition.
Claim 4
Dependent Claim
30 words
The composition of claim 1 wherein said composition of the second gel comprises from about 0.5% to about 5% of solid polysulfonic acid salt by weight of the total composition.
Claim 5
Dependent Claim
19 words
The composition of claim 1 wherein said protic acid has a pK of from about 2.8 to about 4.2
Claim 6
Dependent Claim
12 words
The composition of claim 4 wherein said protic acid is salicylic acid.
Claim 7
Dependent Claim
20 words
The composition of claim 2 wherein said composition contains sufficient amounts of fillers and binders to form a topical cream.
Claim 8
Dependent Claim
21 words
The composition of claim 2 wherein said composition comprises sufficient amounts and kinds of fillers and binders to form a toothpaste.
Claim 9
Dependent Claim
12 words
The composition of claim 1 wherein said first gel comprises hydroxyethyl cellulose.
Claim 10
Dependent Claim
23 words
The composition of claim 1 wherein the molecular weight of the anionic portion of said polymer is from about 2,500,000 to about 4,500,000.
Claim 11
Dependent Claim
29 words
The composition of claim 1 wherein the cation of the polymer is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, triethanolamine, and 2-amino-2-methyl-1-propanol and mixtures thereof.
Claim 12
Independent Claim
140 words
A method for treating skin diseases comprising applying to the affected area of the skin an effective amount of a composition comprising two gels adapted to be simultaneously applied and mixed in situ and to adhere onto said substrate, said first gel comprising an aqueous solution containing suitable amounts of a protic acid, and said second gel comprising an amount of metal chlorite such that when the gels are combined, the chlorite ion concentration in the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration and wherein said second gel also contains a polysulfonic acid salt wherein the anion of said salt has the formula: wherein X has a value such that the molecular weight of the anionic portion of the polymer is from about 1,000,000 to about 5,000,000.
Claim 13
Independent Claim
140 words
A method for treating skin diseases comprising applying to the affected area of the skin an effective amount of a composition comprising two gels adapted to be simultaneously applied and mixed in situ and to adhere onto said substrate, said first gel comprising an aqueous solution containing suitable amounts of a protic acid, and said second gel comprising an amount of metal chlorite such that when the gels are combined, the chlorite ion concentration in the form of chlorous acid is no more than about 15% by weight of the total amount of chlorite ion concentration and wherein said second gel also contains a polysulfonic acid salt wherein the anion of said salt has the formula: wherein X has a value such that the molecular weight of the anionic portion of the polymer is from about 1,000,000 to about 5,000,000.
Claim 14
Dependent Claim
25 words
The method of claim 11 wherein said composition comprises from about 5% to about 15% of polysulfonic acid salt by weight of the total composition.
Claim 15
Dependent Claim
25 words
The method of claim 11 wherein said composition comprises from about 0.5% to about 5% of polysulfonic acid salt by weight of the total composition.
Claim 16
Dependent Claim
19 words
The method of claim 11 wherein said protic acid has a pK of from about 2.8 to about 4.2.
Claim 17
Dependent Claim
12 words
The method of claim 14 wherein said protic acid is salicylic acid.
Claim 18
Dependent Claim
20 words
The method of claim 12 wherein said composition contains sufficient amounts of fillers and binders to form a topical cream.
Claim 19
Dependent Claim
21 words
The method of claim 12 wherein said composition comprises sufficient amounts and kinds of fillers and binders to form a toothpaste.
Claim 20
Dependent Claim
12 words
The method of claim 11 wherein said first gel comprises hydroxyethyl cellulose.
Claim 21
Dependent Claim
23 words
The method of claim 11 wherein the molecular weight of the anionic portion of said polymer is from about 2,500,000 to about 4,500,000.
Claim 22
Dependent Claim
29 words
The method of claim 11 wherein the cation of the polymer is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, triethanolamine, and 2-amino-2-methyl-1-propanol and mixtures thereof.
Claim 23
Dependent Claim
75 words
A disinfectant oral hygiene composition for reducing dental plaque comprising: a flavoring agent acceptable for oral hygiene compositions; an aqueous solution containing a suitable amount of an acid; and an amount of a metal chlorite such that the chlorite ion concentration in the form of chlorous acid is no more than about 15 percent by weight of the total amount of chlorite ion concentration, with the proviso that said composition contains substantially no lactic acid.
Claim 24
Dependent Claim
75 words
A disinfectant oral hygiene composition for reducing dental plaque comprising: a flavoring agent acceptable for oral hygiene compositions; an aqueous solution containing a suitable amount of an acid; and an amount of a metal chlorite such that the chlorite ion concentration in the form of chlorous acid is no more than about 15 percent by weight of the total amount of chlorite ion concentration, with the proviso that said composition contains substantially no lactic acid.
Claim 25
Dependent Claim
27 words
The composition of claim 21 wherein said composition contains from about 0.02% to about 0.5% by weight metal chlorite based upon the total weight of said composition.
Claim 26
Dependent Claim
55 words
The composition of claim 21 wherein said composition contains up to about 0.3 percent by weight metal chlorite based upon the total weight of said composition and a suitable amount of an acid having a pK of from about 2.8 to about 4.2, the pH of said composition being from about 2.2 to about 7.0.
Claim 27
Dependent Claim
29 words
The composition of claim 21 wherein said protic acid is at least one acid selected from the group consisting of citric, malic, tartaric, glycolic, mandelic, salicylic, and carbonic acids.
Claim 28
Dependent Claim
12 words
The composition of claim 21 wherein said composition is an aqueous solution.
Claim 29
Dependent Claim
31 words
The composition of claims 25, 32 or 33 wherein said composition contains at least a 10-fold molar excess of a water-soluble chloride ion compared to the total concentration of chlorite ion.
Claim 30
Dependent Claim
14 words
The composition of claims 25 or 36 wherein said metal chlorite is sodium chlorite.
Claim 31
Dependent Claim
35 words
The composition of claim 25 wherein said flavoring agent is at least one agent selected from the group consisting of 1-carvone, aspartame, sacharin, peppermint oil, wintergreen oil, cinnamon oil, clove oil, menthol, thymol or eucalyptol.
Claim 32
Dependent Claim
50 words
The composition of claim 21 wherein said composition comprises: a first aqueous solution of about 0.34% Na4EDTA, about 0.1% 1-carvone (mint flavor) and a suitable amount of a dye; and a second aqueous solution comprising about 0.275% anhydrous citric acid, about 10% glycerin and a suitable amount of a dye.
Claim 33
Dependent Claim
46 words
The composition of claim 21 wherein said composition comprises: a first aqueous solution of about 0.25% N sodium chlorite and about 0.10% sodium hydroxide; and a second aqueous solution of about 10.00% glycerine about 0.5% sodium benzoate, about 0.5% aspartame, a dye and a flavoring agent.
Claim 34
Dependent Claim
94 words
The composition of claim 21 wherein said composition comprises: a first base gel of about 45% polysulfonic acid, about 40% 1 N sodium hydroxide, about 2.0% bentonite, about 1.0% sodium lauryl sulfate, about 1.0% titanium dioxide, about 0.5% amorphous silica, about 0.25% sodium chlorite, and the balance water; and an activator gel comprising about 10.0% glycerin, about 5.0% magnesium aluminum silicate, about 2.0% hydroxyethyl cellulose, about 0.75% malic acid, about 0.4% wintergreen flavor, about 0.06% of a 0.5% solution of a dye, about 0.5% sodium benzoate, about 0.05% sodium saccharine, and the balance water.
Claim 35
Dependent Claim
86 words
A disinfectant oral hygiene composition for reducing dental plaque comprising: a flavoring agent acceptable for oral hygiene compositions; an aqueous solution containing a compound which contains at least two vicinal hydroxy groups; a suitable amount of a protic acid; and an amount of a metal chlorite such that the chlorite ion concentration in the form of chlorous acid is no more than about 15 percent by weight of the total amount of chlorite ion concentration, with the proviso that said composition contains substantially no lactic acid.
Claim 36
Dependent Claim
86 words
A disinfectant oral hygiene composition for reducing dental plaque comprising: a flavoring agent acceptable for oral hygiene compositions; an aqueous solution containing a compound which contains at least two vicinal hydroxy groups; a suitable amount of a protic acid; and an amount of a metal chlorite such that the chlorite ion concentration in the form of chlorous acid is no more than about 15 percent by weight of the total amount of chlorite ion concentration, with the proviso that said composition contains substantially no lactic acid.
Claim 37
Dependent Claim
74 words
A disinfectant oral hygiene composition for reducing dental plaque and controlling gingivitis and periodontitis comprising: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
Claim 38
Dependent Claim
74 words
A disinfectant oral hygiene composition for reducing dental plaque and controlling gingivitis and periodontitis comprising: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
Claim 39
Dependent Claim
23 words
The composition of claim 33 wherein said composition contains from about 0.02 to about 0.5 percent by weight, a chlorine dioxide liberating compound.
Claim 40
Dependent Claim
22 words
The composition of claim 33 wherein said composition contains from about 0.03% to about 0.3% by weight, a chlorine dioxide liberating compound.
Claim 41
Dependent Claim
15 words
The composition of claim 33 wherein said chlorine dioxide liberating compound is a water-soluble chlorite.
Claim 42
Dependent Claim
72 words
A process for producing a disinfectant oral hygiene composition, said process comprising admixing: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
Claim 43
Dependent Claim
72 words
A process for producing a disinfectant oral hygiene composition, said process comprising admixing: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
Claim 44
Dependent Claim
81 words
A process for reducing dental plaque and controlling gingivitis and periodontitis in the mouth comprising treating the mouth with a composition comprising: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
Claim 45
Dependent Claim
81 words
A process for reducing dental plaque and controlling gingivitis and periodontitis in the mouth comprising treating the mouth with a composition comprising: a flavoring agent acceptable for oral hygiene compositions; from about 0.03% to about 0.3% by weight of a chlorine dioxide liberating compound based upon the total weight of said composition; and a suitable amount of an organic acid having a pK of from about 2.8 to about 4.2, with the proviso that said composition contains substantially no lactic acid.
References Cited (Backward Citations)
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