EP0253472A1
Expired / Lapsed
EP
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Ophthalmic flurbiprofen preparation
Assignee: Kaken Pharmaceutical Co Ltd
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Filing: 1987-05-15
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Granted: —
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Expires: 2007-05-15
Abstract
Abstract An ophthalmic preparation comprises a fat emulsion containing flurbiprofen or a soybean oil-soluble derivative thereof such as an ester, as an active ingredient, a phospholipid emulsifier and soybean oil, the flurbiprofen or derivative thereof being dissolved in the soybean oil.
Inventors
- 👤 Yutaka Mizushima
- 👤 Hiroyuki Okamoto
- 👤 Shigetoshi Sugio
- 👤 Kazumasa Yokoyama
- 👤 Tadakazu Suyama
- 👤 Masao Tono
- 👤 Makoto Okumura
- 👤 Yoshiaki Konishi
- 👤 Kiyonoshin Ichikawa
- 👤 Katsuhiro Uchida
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K31/00; A61K31/185; A61K31/19; A61K9/10; A61K9/107; A61K9/1075; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
42 words
A fat emulsion containing a phospholipid emulsifier and emulsified soybean oil in which flurbiprofen or its derivative is dissolved, the derivative being a soybean oil-soluble ester of flurbiprofen; characterized in that the fat emulsion is used for manufacturing an ophthalmic medicine preparation.
Claim 2
Dependent Claim
42 words
A fat emulsion containing a phospholipid emulsifier and emulsified soybean oil in which flurbiprofen or its derivative is dissolved, the derivative being a soybean oil-soluble ester of flurbiprofen; characterized in that the fat emulsion is used for manufacturing an ophthalmic medicine preparation.
Claim 3
Dependent Claim
106 words
A fat emulsion of claim 1, characterized in that the derivative is an ester of flurbiprofen represented by the formula wherein R is a C₁-C₈ alkyl group or a group of the formula wherein R₁ is a hydrogen atom or a C₁-C₃ alkyl group, R₂ is a C₁-C₁₅ alkyl group or a C₂-C₈ alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula wherein R₃ and R₄ are same as or different from each other and are a hydrogen atom or a C₁-C₃ alkyl group, and n is an integer of 1 or 2; and an aqnueous medium.
Claim 4
Dependent Claim
47 words
A fast emulsion of claim 1, characterized in that it contains 0.001 - 5% (W/V) of flurbiprofen, 1 - 20% (W/V) of soybean oil, 1 - 50 parts by weight of phospholipid based on 100 parts by weight of the soybean oil and the balance aqueous medium.
Claim 5
Dependent Claim
34 words
A fat emulsion of claim 1, characterized in that effective amount as an emulsifying adjuvant of a fatty acid having 6 to 22 carbon atoms or a physiologically acceptable salt thereof is also included.
Claim 6
Dependent Claim
25 words
A fat emulsion of claim 1, characterized in that a stabilizing amount of cholesterol, phosphatidic acid or mixture thereof is further contained as a stabilizer.
Claim 7
Dependent Claim
47 words
A fat emulsion of claim 1, characterized in that stabilizing amount of an albumin, a dextran, a polyvinyl pyrrolidone, a polyalkylene glycol having a molecular weight of 1,000 to 10,000, a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 1,000 to 20,000, gelatin or hydroxyethylstarch is also included.
Claim 8
Dependent Claim
20 words
A fat emulsion of claim 1, characterized in that the emulsion of itself is used for manufacturing an ophthalmic lation.
Claim 9
Dependent Claim
28 words
A fat emulsion of claim 1, characterized in that a freeze-dried powder of the fat emulsion is used for manufacturing a ophthalmic ointment together with an ointment base.
Claim 10
Dependent Claim
21 words
A fat emulsion of any one of claims 1 to 6, characterized in that the flurbiprofen is used for the purpose.
Claim 11
Dependent Claim
33 words
A fat emulsion of any one of claims 1 to 6, characterized in that as the flurbiprofen derivative flurbiprofen cetyl ester, flurbiprofen acetoxymethyl ester or flurbiprofen acetoxyethyl ester is used for the purpose.
Claim 12
Dependent Claim
31 words
Use of a fat emulsion containing a phospholipid emulsifier and emulsified soybean oil in which flurbiprofen or a soybean oil-soluble ester of flurbiprofen is dissolved, for manufacturing an ophthalmic medicine preparation.
Claim 13
Dependent Claim
31 words
Use of a fat emulsion containing a phospholipid emulsifier and emulsified soybean oil in which flurbiprofen or a soybean oil-soluble ester of flurbiprofen is dissolved, for manufacturing an ophthalmic medicine preparation.
Claim 14
Dependent Claim
18 words
A method of ophthalmic treatment which comprises applying the fat emulsion of claim 1 to eye suffering inflammation.
Claim 15
Dependent Claim
20 words
A method according to claim 12 wherein the ophthalmic preparation is in the form of a lotion or an ointment.
Claim 16
Dependent Claim
20 words
A method according to claim 12 wherein dosage of the preparation is 0.1 - 1000 µg/day in terms of flurbiprofen.
Claim 17
Dependent Claim
43 words
The use of a fat emulsion in the manufacture of an ophthalmic medicament for topical treatment of the eye, which fat emulsion contains a phospholipid emulsifier, an emulsified soybean oil and flurbiprofen, or a soybean oil-soluble derivative thereof, dissolved in the soybean oil.
Claim 18
Dependent Claim
43 words
The use of a fat emulsion in the manufacture of an ophthalmic medicament for topical treatment of the eye, which fat emulsion contains a phospholipid emulsifier, an emulsified soybean oil and flurbiprofen, or a soybean oil-soluble derivative thereof, dissolved in the soybean oil.
Claim 19
Dependent Claim
14 words
The use according to claim 15, wherein the fat emulsion contains an aqueous medium.
Claim 20
Dependent Claim
12 words
The use according to claim 15, wherein the fat emulsion is freeze-dried.
Claim 21
Dependent Claim
23 words
The use according to claim 15, wherein the fat emulsion contains a flurbiprofen ester of the formula given and defined in claim 2.
Claim 22
Dependent Claim
24 words
The use according to claim 15, wherein the fat emulsion is as defined in any one of claims 2 to 6, 9 and 10.
Claim 23
Dependent Claim
18 words
The use according to any one of claims 15 to 19, wherein the medicament comprises an ophthalmic lotion.
Claim 24
Dependent Claim
18 words
The use according to any one of claims 15 to 19, wherein the medicament comprises an ophthalmic ointment.
References Cited (Backward Citations)
EP0082921A1
Cited
EP0129435A2
Cited
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