EP0247378B1
Expired / Lapsed
EP
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Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one derivatives
Assignee: Kanegafuchi Chemical Industry Co Ltd
•
Filing: 1987-04-29
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Granted: 1990-09-19
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Expires: 2007-04-29
Abstract
No abstract record available.
Inventors
- 👤 Kazunori Kan
- 👤 Noboru Ueyama
- 👤 Isao Sada
- 👤 Takehisa Ohashi
- 👤 Kiyoshi Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 17:10
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
98 words
A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): wherein R 1 is a protective group for the hydroxyl group, which comprises reacting a p-lactam compound having the formula (I): wherein R 1 is as defined above, and R 2 , R 3 and R 4 are a lower alkyl group having 1 to 6 carbon atoms, phenyl group or an aralkyl group, with acetic anhydride in an organic solvent in the presence of 0.2 to 3% by weight of a dialkylaminopyridine or a substituted pyridine, which has a heterocyclic group containing nitrogen atom as substituent.
Claim 2
Dependent Claim
98 words
A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): wherein R 1 is a protective group for the hydroxyl group, which comprises reacting a p-lactam compound having the formula (I): wherein R 1 is as defined above, and R 2 , R 3 and R 4 are a lower alkyl group having 1 to 6 carbon atoms, phenyl group or an aralkyl group, with acetic anhydride in an organic solvent in the presence of 0.2 to 3% by weight of a dialkylaminopyridine or a substituted pyridine, which has a heterocyclic group containing nitrogen atom as substituent.
Claim 3
Dependent Claim
34 words
The process of Claim 1, wherein said organic solvent contains a member selected from the group consisting of 0.1 to 1% by volume of water and 0.6 to 5% by volume of acetic acid.
Claim 4
Dependent Claim
32 words
The process of Claim 1, wherein R 1 is a group of the formula (III): wherein R5, R6 and R 7 are a lower alkyl group having 1 to 6 carbon atoms.
Claim 5
Dependent Claim
11 words
The process of Claim 1, wherein R 1 is t-butyldimethylsilyl group.
Claim 6
Dependent Claim
11 words
The process of Claim 1, wherein R 1 is isopropyldimethylsilyl group.
Claim 7
Dependent Claim
11 words
The process of Claim 1, wherein R 1 is dimethyl-1,1,2-trimethylpropylsilyl group.
Claim 8
Dependent Claim
16 words
The process of Claim 1, wherein R 2 , R 3 and R4 are methyl groups.
Claim 9
Dependent Claim
10 words
The process of Claim 1, wherein said dialkylaminopyridine is 4-dimethylaminopyridine.
Claim 10
Dependent Claim
11 words
The process of Claim 1, wherein said substituted pyridine is 4-pyrrolidinopyridine.
Claim 11
Dependent Claim
11 words
The process of Claim 1, wherein said substituted pyridine is 4-piperidinopyridine.
Claim 12
Dependent Claim
11 words
The process of Claim 1, wherein said organic solvent is tetrahydrofuran.
Claim 13
Dependent Claim
11 words
The process of Claim 1, wherein said organic solvent is pyridine.
References Cited (Backward Citations)
No citation records indexed.
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