EP0236949A2
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Blood preservation
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1987-03-05
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Granted: —
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Expires: 2007-03-05
Abstract
Abstract The physiological activity of red blood cells is prolonged when stored by an aqueous solution containing oxalic acid or its salt. Therefore, a composition for blood preservation containing oxalic acid or its salt are useful for long-term storage of blood, especially red blood cells.
Inventors
- 👤 Isuke Imada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:02
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/18
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
55 words
A method for preserving red blood cells, characterized by suspending said red blood cells in an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof to render a concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared.red blood cells suspension 0.1 to 1 mM.
Claim 2
Independent Claim
55 words
A method for preserving red blood cells, characterized by suspending said red blood cells in an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof to render a concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared.red blood cells suspension 0.1 to 1 mM.
Claim 3
Dependent Claim
28 words
A method according to claim 1, wherein the concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared suspension is 0.1 to '0.4 mM.
Claim 4
Dependent Claim
34 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) glucose, (2) sodium chloride, (3) mannitol, (4) adenine and (5) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 5
Dependent Claim
33 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) sodium citrate, (2) citric acid, (3) glucose and (4) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 6
Dependent Claim
37 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) sodium citrate, (2) citric acid, (3) sodium dihydrogen phosphate, (4) glucose and (5) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 7
Dependent Claim
35 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) sodium citrate, (2) citric acid, (3) glucose, (4) adenine and (5) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 8
Dependent Claim
39 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) sodium citrate, (2) citric acid, (3) sodium dihydrogen phosphate, (4) glucose, (5) adenine and (6) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 9
Dependent Claim
36 words
A method according to claim 1, wherein the aqueous solution for blood preservation comprises (1) glucose, (2) scdium chloride, (3) sodium citrate, (4) citric acid and (5) oxalic acid or a physiologically acceptable water-soluble salt thereof.
Claim 10
Independent Claim
50 words
A method for preserving blood, characterized by adding an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof to said blood to render a concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared blood suspension 0.1 to 1 mM.
Claim 11
Independent Claim
50 words
A method for preserving blood, characterized by adding an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof to said blood to render a concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared blood suspension 0.1 to 1 mM.
Claim 12
Dependent Claim
29 words
A method according to claim 9, wherein the concentration of oxalic acid or a physiologically acceptable water-soluble salt thereof in the prepared blood suspension is 0.1 to 0.4 mM.
Claim 13
Dependent Claim
49 words
An improved composition for preservation of blood or red blood cells containing an anticoagulant or a preservative for red blood cells, the improvement which comprises incorporating oxalic acid or a physiologically acceptable water-soluble salt thereof to the composition to maintain the physiological activity of blood or red blood cells.
Claim 14
Dependent Claim
49 words
An improved composition for preservation of blood or red blood cells containing an anticoagulant or a preservative for red blood cells, the improvement which comprises incorporating oxalic acid or a physiologically acceptable water-soluble salt thereof to the composition to maintain the physiological activity of blood or red blood cells.
Claim 15
Dependent Claim
32 words
A suspension of red blood cells in an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof of which the concentration is 0.1 to 1 mM.
Claim 16
Dependent Claim
32 words
A suspension of red blood cells in an aqueous solution for blood preservation containing oxalic acid or a physiologically acceptable water-soluble salt thereof of which the concentration is 0.1 to 1 mM.
References Cited (Backward Citations)
No citation records indexed.
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