EP0231573A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Improved ionic heparin coating
Assignee: Baxter International Inc
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Filing: 1986-07-03
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Granted: —
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Expires: 2006-07-03
Abstract
Abstract A non thrombogenic quarternary ammonium/heparin complex coating for a medical article is disclosed where the organic cationic salt is an alkylbenzyldimethyl ammonium ion present in an amount of at least 50%, by weight and having the following formula: where R is a uniform alkyl group containing between 16 to 18 carbon atoms.
Inventors
- 👤 Li Chen Hsu
- 👤 Sun De Tong
- 👤 David Paul Balding
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 17:23
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
54 words
1, A blood contacting medical article comprising: a) a substrate surface; and b) an anti - thrombogenic surface coating of a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt having the following formula: where R is an alkyl group having from. 16 to 18 carbon atoms.
Claim 2
Dependent Claim
54 words
1, A blood contacting medical article comprising: a) a substrate surface; and b) an anti - thrombogenic surface coating of a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt having the following formula: where R is an alkyl group having from. 16 to 18 carbon atoms.
Claim 3
Dependent Claim
11 words
The medical article of Claim 1 wherein complex is cetalkonium heparin.
Claim 4
Dependent Claim
12 words
The medical article of Claim 2 wherein the complex is stearylkonium heparin.
Claim 5
Dependent Claim
14 words
The medical article of Claim 1 wherein the substrate surface comprises a polymeric resin.
Claim 6
Dependent Claim
26 words
The medical article of Claim 1 wherein the organic cationic salt is present in an amount of 60 to 70% by weight of the complex composition.
Claim 7
Dependent Claim
59 words
A process for rendering the surfaces of blood contacting medical articles non - thrombogenic comprising: a) providing a medical article; and b) coating the medical article with a complex of heparin and at least 50% by weight of an alkylbenzyl dimethyl ammonium cationic salt of the formula: where R is an alkyl group from 16 to 18 carbon atoms.
Claim 8
Dependent Claim
59 words
A process for rendering the surfaces of blood contacting medical articles non - thrombogenic comprising: a) providing a medical article; and b) coating the medical article with a complex of heparin and at least 50% by weight of an alkylbenzyl dimethyl ammonium cationic salt of the formula: where R is an alkyl group from 16 to 18 carbon atoms.
Claim 9
Dependent Claim
43 words
The process of Claim 6 wherein the coating step comprises: (a) providing an organic solution of the heparin complex; (b) applying the solution to the surface of a medical article; and (c) drying the medical article to form an integral adhesive coating thereon.
Claim 10
Dependent Claim
60 words
A process of Claim 6'.wherein the coating step comprises: a) treating the medical article with a solution of a cationic quarternary ammonium organic salt having the following formula: where R is an alkyl group containing from 16 to 18 carbon atoms and X is a halogen; and b) subsequently treating the medical article with an aqueous solution of heparin salt.
Claim 11
Dependent Claim
20 words
The process of Claim 6 wherein the organic cationic salt consists of an alkyl R group of 16 carbon atoms.
Claim 12
Dependent Claim
20 words
The process of Claim 6 wherein the organic cationic salt consists of an alkyl R group of 18 carbon atoms.
References Cited (Backward Citations)
No citation records indexed.
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