EP0230635A2
Expired / Lapsed
EP
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Tubular prosthesis having a composite structure
Assignee: Sumitomo Electric Industries Ltd
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Filing: 1986-12-22
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Granted: —
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Expires: 2006-12-22
Abstract
Abstract A tubular prosthesis having a composite structure comprising (i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present in the portion of the tube wall which is closest to the outer surface thereof while at least one of albumin and chitosan is present in the portion of the tube wall which is closest to the inner surface thereof, and heparin is present in the inner surface of the tube wall.
Inventors
- 👤 Koichi Osaka Works Okita
- 👤 Shigeru Osaka Works Asako
- 👤 Katsuya Osaka Works Yamada
- 👤 Kazuhiro Osaka Works Okabe
- 👤 Tohru Osaka Works Kashiwagi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:46
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/16
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
183 words
A tubular prosthesis having a composite structure comprising (i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present in the portion of the tube wall which is closest to the outer surface thereof while at least one of albumin and chitosan is present in the portion of the tube wall which is closest to the inner surface thereof, and heparin is present in the inner surface of the tube wall.
Claim 2
Dependent Claim
183 words
A tubular prosthesis having a composite structure comprising (i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present in the portion of the tube wall which is closest to the outer surface thereof while at least one of albumin and chitosan is present in the portion of the tube wall which is closest to the inner surface thereof, and heparin is present in the inner surface of the tube wall.
Claim 3
Dependent Claim
35 words
A tubular prosthesis having a composite structure as in claim 1, wherein the outer surface of said tubular polytetrafluoroethylene has an average fibril length which is at least 5 times that of the inner surface.
Claim 4
Dependent Claim
35 words
A tubular prosthesis having a composite structure as in claim 2, wherein the outer surface of said tubular polytetrafluoroethylene has an average fibril length which is at least 10 times that of the inner surface.
Claim 5
Dependent Claim
38 words
A tubular prosthesis having a composite structure as in claim 1, wherein the nodes in the outer surface of said tubular polytetrafluoroethylene have a thickness which is at least 10 times that of nodes in the inner surface.
Claim 6
Dependent Claim
35 words
A tubular prosthesis having a composite structure as in claim 1, wherein said collagen has been freed of any antigenic groups by the treatment with pepsin and has been crosslinked with glutaraldehyde or dialdehyle starch.
Claim 7
Dependent Claim
33 words
A tubular prosthesis having a composite structure as in claim 1, wherein said chitosan is made by the partial acetylation with alkali of chitin and has been crosslinked with glutaraldehyde or dialdehyde starch.
Claim 8
Dependent Claim
25 words
A tubular prosth esis having a composite structure as in claim 1, wherein said tubular prosthesis has an inner diameter of 5 mm or less.
Claim 9
Dependent Claim
25 words
A tubular prosthesis having a composite structure as in claim 7, wherein said tubular prosthesis has an inner diameter of from 1 to 3 mm.
Claim 10
Dependent Claim
47 words
A tubular prosthesis having a composite structuer as in claim 1, wherein said tubular polytetrafluoroethylene has an average pore size in the inner surface thereof of from 1 to 100 micrometers and an average pore size in the outer surface thereof of from 0.1 to 1.0 mm.
Claim 11
Dependent Claim
23 words
A tubular prosthesis having a composite structure as in claim 1, wherein said tubular polytetrafluoroethylene has a porosity of from 70 to 90%.
Claim 12
Dependent Claim
23 words
A tubular prosthesis having a composite structure as in claim 10, wherein said tubular polytetrafluoroethylene has a porosity of from 75 to 80%.
References Cited (Backward Citations)
No citation records indexed.
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