EP0227400A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Inhibition of post-surgical adhesion formation by the topical administration of tissue plasminogen activator
Assignee: Ethicon Inc
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Filing: 1986-12-15
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Granted: —
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Expires: 2006-12-15
Abstract
Abstract Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of tissue plasminogen activator.
Inventors
- 👤 Warren D. Sheffield
- 👤 Gere D. Dizerega
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:16
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/49; A61K9/00; A61K9/10; A61K9/127; A61P; A61P17/00; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
27 words
A pharmaceutical composition for topical application comprising a topically effective amount of tissue plasminogen activator (t-PA) as the active ingredient in a topically applicable pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
27 words
A pharmaceutical composition for topical application comprising a topically effective amount of tissue plasminogen activator (t-PA) as the active ingredient in a topically applicable pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
27 words
The composition of claim 1 wherein the carrier is a controlled release carrier which releases the active ingredient in an effective amount over a period of time.
Claim 4
Dependent Claim
17 words
The composition of claim 2 wherein said period of time is from about one to seven days.
Claim 5
Dependent Claim
14 words
The composition of claim 2 or claim 3 wherein said carrier is a phospholipid.
Claim 6
Dependent Claim
12 words
The composition of claim 4 wherein said phospholipid is a phospholipid vesicle.
Claim 7
Dependent Claim
15 words
The composition of claim 2 or claim 3 wherein said carrier is an absorbable polymer.
Claim 8
Dependent Claim
17 words
The composition of claim 1 wherein the carrier is an aqueous composition including a surface active agent.
Claim 9
Dependent Claim
14 words
The composition of claim 1, wherein the carrier is an aqueous isotonic buffer solution.
Claim 10
Dependent Claim
25 words
The composition of any one of claims 1 to 8 wherein the concentration of active ingredient in said composition is about 0.015 milligrams per milliliter.
Claim 11
Dependent Claim
23 words
Use of t-PA in the production of a topically applicable medicament for topical use in inhibiting the formation of post-surgical adhesions in mammals.
Claim 12
Dependent Claim
23 words
Use of t-PA in the production of a topically applicable medicament for topical use in inhibiting the formation of post-surgical adhesions in mammals.
Claim 13
Dependent Claim
30 words
Use of t-PA in the production of a composition according to any one of claims 1 to 9 for topical use in inhibiting the formation of post-surgical adhesions in mammals.
References Cited (Backward Citations)
No citation records indexed.
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