Polyether antibiotic and process for its production

Claim 2

Antibiotic A80438 of the formula 1: or an acyl, alkyl ester, alkyl ether or urethane derivative, or a salt thereof.

Claim 3

A80438.

Claim 4

A80438.

Claim 5

The sodium salt of A80438.

Claim 6

The sodium salt of A80438.

Claim 7

A compound of formula 1 as claimed in any one of claims 1 to 3, for use in preventing or treating microbial infections.

Claim 8

A compound of formula 1 as claimed in any one of claims 1 to 3, for use as a growth promotor.

Claim 9

A process for preparing a compound of formula 1, as claimed in any one of claims l to 3, which comprises cultivating Streptomyces bobili NRRL 15971, or Streptomyces pactum NRRL 15970, or an A80438-producing variant, mutant or recombinant thereof, in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until antibiotic A80438 is produced, optionally followed by separating A80438 from the culture medium.

Claim 10

Streptomyces bobili NRRL 15971.

Claim 11

Streptomyces bobili NRRL 15971.

Claim 12

Streptomyces pactum NRRL 15970.

Claim 13

Streptomyces pactum NRRL 15970.

Claim 14

A poultry feedstuff composition comprising a first component which is a compound of formula 1 as claimed in any one of claims 1 to 3 and a second component which is selected from the group consisting of a) nicarbazin, b) 4,4'-dinitrocarbanilide, c) a naphthalenamine of the formula wherein: R 2 is C 1 -C 4 alkyl; R 3 is halogen, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy or C 1 -C 4 fluoroalkylthio; R 4 is halogen; R 5 is hydrogen or halogen; m is 0, 1 or 2; and n is 0 or 1; with the proviso that, when an R 4 substituent exists, it is at other than the 2-position; d) a benzenamine selected from 2,4-dinitro-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)benzenamine, 2,4-dinitro-N-[4-(1,1,2,2-tetrafluoroethoxy)-phenyl]-6-(trifluoromethyl)benzenamine or 2,4-dinitro-N-[4-(pentafluoroethoxy)phenyl]-6-(trifluoromethyl)-benzenamine; e) metichlorpindol; or f) a pharmaceutically acceptable salt of an (a)-(e) compound; the components being present in the feedstuff in amounts which, in combination, are synergistic as to at least one coccidiosis-causing strain of Eimeria.

Claim 15

A process for preparing antibiotic A80438 of the formula 1: or an acyl, alkyl ester, alkyl ether or urethane derivative, or a salt thereof, which comprises cultivating Streptomyces bobili NRRL 15971, or Streptomyces 2actum NRRL 15970, or an A80438-producing variant, mutant or recombinant thereof, in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until antibiotic A80438 is produced, optionally followed by separating A80438 from the culture medium.

Claim 16

A process for preparing antibiotic A80438 of the formula 1: or an acyl, alkyl ester, alkyl ether or urethane derivative, or a salt thereof, which comprises cultivating Streptomyces bobili NRRL 15971, or Streptomyces 2actum NRRL 15970, or an A80438-producing variant, mutant or recombinant thereof, in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until antibiotic A80438 is produced, optionally followed by separating A80438 from the culture medium.

Claim 17

A process according to claim 1 for preparing A80438 as its sodium salt.