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EP0184470A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Hydrophilic, pressure sensitive biomedical adhesive composition

Assignee: Medtronic Inc
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Filing: 1985-12-06
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Granted: —
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Expires: 2005-12-06
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Abstract

Abstract @ A hydrophilic, skin-compatible, pressure sensitive, adhesive gel/hydrogel composition comprising: 25 to 50 weight pecent polyvinyl pyrrolidone (PVP) having a weight average molecular weight of at least about 100000, and preferably in the range of about 100,000 to 600,000; 2 to 5 weight percent polyvinyl alcohol (PVA) preferably having a weight average molecular weight in the range of about 150,000 to 300,000; 5 to 41 weight percent polar plasticizer or humectant; 3 to 50 weight percent water; and about 0 to about 50 weight percent of a further ionic or non-ionic species. In a preferred aspect, the composition of the invention is suitable for use in an iontophoresis device to provide a hydrophilic gel matrix from which a drug is iontophoretically delivered.

Inventors

  • 👤 Allan H. Jevne
  • 👤 Brett R. Vegoe
  • 👤 Carolann M. Holmblad
  • 👤 Patrick T. Cahalan

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 19:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L15/585; C; C09; C09J; C09J139/00; C09J139/04; C09J139/06; C08; C08L; C08L2666/00; C08L2666/02; C08L2666/04; C08L29/00; C08L29/02; C08L29/04; C09J2301/00; C09J2301/30; C09J2301/302

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 60 words
A skin-compatible, hydrophilic adhesive composition comprising: 25 to 50 weight percent polyvinyl pyrrolidone having a weight average molecular weight of at least about 100000; 2 to 5 weight percent polyvinyl alcohol; 5 to 41 weight percent polar plasticizer or humectant; 3 to 50 weight percent water: and about 0 to 50 weight percent of a further ionic or nonionic species.
Claim 2
Dependent Claim 60 words
A skin-compatible, hydrophilic adhesive composition comprising: 25 to 50 weight percent polyvinyl pyrrolidone having a weight average molecular weight of at least about 100000; 2 to 5 weight percent polyvinyl alcohol; 5 to 41 weight percent polar plasticizer or humectant; 3 to 50 weight percent water: and about 0 to 50 weight percent of a further ionic or nonionic species.
Claim 3
Dependent Claim 19 words
A composition as claimed in claim 1 wherein there is from about 30 to 40 weight percent polyvinyl pyrrolidone.
Claim 4
Dependent Claim 22 words
A composition as claimed in either of claims 1 and 2 wherein there is about 3 to 4 weight percent polyvinyl alcohol.
Claim 5
Dependent Claim 30 words
A composition as claimed in any one of claims 1 to 3 wherein the polyvinyl pyrrolidone has a weight average molecular weight in the range of about 100,000 to 600,000.
Claim 6
Dependent Claim 30 words
A composition as claimed in any one of claims 1 to 4 wherein the polyvinyl pyrrolidone has a weight average molecular weight in the range of about 300,000 to 400,000.
Claim 7
Dependent Claim 30 words
A composition as claimed in any one of claims 1 to 5 wherein the polyvinyl alcohol has a weight average molecular weight in the range of about 150,000 to 300,000.
Claim 8
Dependent Claim 30 words
A composition as claimed in any one of claims 1 to 6 wherein the polyvinyl alcohol has a weight average molecular weight in the range of about 170,000 to 220,000.
Claim 9
Dependent Claim 26 words
A composition as claimed in any one of claims 1 to 7 wherein the polar plasticizer comprises a material selected from glycerol, sorbitol, and poly(ethylene) glycol.
Claim 10
Dependent Claim 25 words
A composition as claimed in any one of claims 1 to 8 further containing from about 0 to about 22 weight percent of an additive.
Claim 11
Dependent Claim 55 words
A composition as claimed in claim 9 where said additive is selected from the group consisting of hydroxy propyl methyl cellulose, carboxy methyl cellulose, cellulose, hydroxy propyl quar, dextran, silica, poly(AMPS) and salts thereof, polyacrylic acid and salts thereof, polystyrene sulfonic acid and salts thereof, karaya gum, xanthan gum, quar gum and locust bean gum.

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