EP0171176A2
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EP
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Bone repair using collagen
Assignee: Collagen Aesthetics Inc
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Filing: 1985-07-03
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Granted: —
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Expires: 2005-07-03
Abstract
Abstract A composition for repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or a mixture thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats or sheets. The bone collagen powder and the formed reconstituted skin collagen are aspects of the invention.
Inventors
- 👤 Donald G. Wallace
- 👤 Karl A. Piez
- 👤 Thomas L. Smestad
- 👤 Saeid Seyedin
- 👤 John M. Mcpherson
- 👤 Rosa Armstrong
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 04:01
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K; A61K38/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
60 words
A method of preparing a composition for effecting conductive repair of a bone defect in a mammal, which method comprises using a preparation of collagen selected from the group consisting of: (1) bone collagen powder; (2) purified atelopeptide reconstituted fibrillar skin collagen; (3) a lyophilized gel of purified atelopeptide reconstituted fibrillar skin collagen; and (4) mixtures of (1) and (2)
Claim 2
Independent Claim
60 words
A method of preparing a composition for effecting conductive repair of a bone defect in a mammal, which method comprises using a preparation of collagen selected from the group consisting of: (1) bone collagen powder; (2) purified atelopeptide reconstituted fibrillar skin collagen; (3) a lyophilized gel of purified atelopeptide reconstituted fibrillar skin collagen; and (4) mixtures of (1) and (2)
Claim 3
Dependent Claim
20 words
The method according to claim 1 wherein the preparations of collagen in (2) and (3) are preared from calf skin.
Claim 4
Dependent Claim
22 words
The method according to claim 1 or claim 2 wherein the preparation of collagen in (3) has been formed into a sheet.
Claim 5
Dependent Claim
25 words
The method according to claim 1, claim 2 or claim 3, wherein the preparations of collagen in (2) and (3) are substantially free of cross-linking.
Claim 6
Dependent Claim
29 words
A purified collagen preparation consisting essentially of (a) a collagen powder derived from bone or (b) a lyophilized reconstituted atelopeptide fibrillar skin collagen in the form of a sheet.
Claim 7
Dependent Claim
29 words
A purified collagen preparation consisting essentially of (a) a collagen powder derived from bone or (b) a lyophilized reconstituted atelopeptide fibrillar skin collagen in the form of a sheet.
Claim 8
Dependent Claim
19 words
A purified collagen preparation according to claim 5 wherein the reconstituted collagen of (b) is substantially free of cross-linking.
Claim 9
Dependent Claim
34 words
A process for preparing lyophilized collagen mats suitable for use as bone implants which process comprises: (a) forming a suspension of purified atelopeptide reconstituted fibrillar skin collagen into sheets, and (b) lyophilizing the resultant.
Claim 10
Dependent Claim
34 words
A process for preparing lyophilized collagen mats suitable for use as bone implants which process comprises: (a) forming a suspension of purified atelopeptide reconstituted fibrillar skin collagen into sheets, and (b) lyophilizing the resultant.
Claim 11
Dependent Claim
33 words
A process for preparing a bone collagen powder suitable for use in repair of bone defects which process comprises treating demineralized bone powder with at least one protease selected from trypsin and pepsin.
Claim 12
Dependent Claim
33 words
A process for preparing a bone collagen powder suitable for use in repair of bone defects which process comprises treating demineralized bone powder with at least one protease selected from trypsin and pepsin.
Claim 13
Dependent Claim
18 words
The preparations (1), (2), (3) or (4) given and defined in claim 1, for use in bone repair.
References Cited (Backward Citations)
No citation records indexed.
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