EP0160483A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Vascular prosthesis
Assignee: Scripps Research Institute
•
Filing: 1985-04-22
•
Granted: —
•
Expires: 2005-04-22
Abstract
Abstract A vascular prosthesis for implantation in a living mammalian body and a method for producing same are disclosed. The vascular prosthesis has a hydrophobic polymeric layer on its luminal surface defining a substantially non-thrombogenic flow surface. The polymeric material of the layer defining the flow surface exhibits a rate of platelet consumption of less than about 20 x 10 8 platelets/cm 2 day.
Inventors
- 👤 Stephen R. Hanson
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 02:28
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/507; A61L33/00; A61L33/06; C; C08; C08L; C08L27/00; C08L27/02; C08L27/12; C08L27/18; C08L75/00; C08L75/04; C08L75/08; C08L83/00; C08L83/04; Y; Y10; Y10S; Y10S534/00; Y10S534/02
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
85 words
A vascular prosthesis for implantation in a living mammalian body comprising (a) an elongated tubular segment, said tubular segment having a substantially foraminous, non-compliant, hollow body portion open at both ends, said hollow body portion having a luminal surface defining a confined-flow passageway, and (b) a hydrophobic, physiologically compatible lining constituted by a polymeric material on said luminal surface and defining a thrombus-resistant flow surface, said polymeric material exhibiting a rate of platelet consumption of less than about 20 x 10 8 platelets/cm 2 day.
Claim 2
Dependent Claim
85 words
A vascular prosthesis for implantation in a living mammalian body comprising (a) an elongated tubular segment, said tubular segment having a substantially foraminous, non-compliant, hollow body portion open at both ends, said hollow body portion having a luminal surface defining a confined-flow passageway, and (b) a hydrophobic, physiologically compatible lining constituted by a polymeric material on said luminal surface and defining a thrombus-resistant flow surface, said polymeric material exhibiting a rate of platelet consumption of less than about 20 x 10 8 platelets/cm 2 day.
Claim 3
Dependent Claim
24 words
The vascular prosthesis of claim I wherein said flow surface is thrombus-resistant at an arterial blood flow rate of at least about 50 millimeters/minute.
Claim 4
Dependent Claim
44 words
The vascular prosthesis of claim lor claim 2 wherein said polymeric material is made up of a polar polymer principally constituted by repeating units of a polyether-based polyurethane derived from a polytetramethylene ether glycol and a mixture of methylene diisocyanate and a diamine coupler.
Claim 5
Dependent Claim
30 words
The vascular prosthesis of claim 1 or claim 2 wherein said polymeric material is made up of a substantially non-polar silicone elastomer principally constituted by repeating units of polydimethylsiloxanemethylvinylsiloxane copolymer.
Claim 6
Dependent Claim
50 words
The vascular prosthesis of claim 1 or claim 2 wherein said lining is constituted by a plurality of discrete, substantially coextensive polymeric layers, the outermost polymeric layer being made up of a polymer principally constituted by repeating units selected from the group consisting of repeating units of tetrafluoroethylene and hexafluoroethane.
Claim 7
Dependent Claim
26 words
A vascular prosthesis of of any preceding claim wherein said lining has a thickness of at least about 100 nanometers and less than about 1.1 millimeters.
Claim 8
Independent Claim
40 words
A method of producing a vascular prosthesis having a luminal surface, comprising the steps of: (a) depositing a polymeric material onto said luminal surface; and, (b) further polymerizing said polymeric material to form a hydrophobic lining on said luminal surface.
Claim 9
Independent Claim
40 words
A method of producing a vascular prosthesis having a luminal surface, comprising the steps of: (a) depositing a polymeric material onto said luminal surface; and, (b) further polymerizing said polymeric material to form a hydrophobic lining on said luminal surface.
Claim 10
Dependent Claim
61 words
The method of claim 7 further including the steps of: (a) dissolving said polymeric material in a compatible solvent to produce a solution; (b) depositing said solution onto said luminal surface; (d) removing said solvent by evaporation from said deposited solution to form a polymeric residue; and (e) curing said polymeric residue to form a hydrophobic lining on said luminal surface.
Claim 11
Dependent Claim
24 words
The method of claim 8 wherein said lining is derived from a silicone elastomer principally constituted by repeating units of polydimethylsiloxane. or claim 9
Claim 12
Dependent Claim
40 words
The method of claim 8 or claim 9 wherein said solution has a concentration of from about 1 percent to about 20 percent by weight of said polymeric material in said solvent, said solvent being an inert, organic, non-polar solvent.
Claim 13
Dependent Claim
20 words
The method of claim 8 wherein said steps (b)-(d) are repeated successively to form a plurality of discrete polymeric layers.
Claim 14
Dependent Claim
37 words
The method of claim 8 including the further step of depositing a polymeric layer defining a flow surface by glow discharge polymerization, said polymeric layer being selected from the group consisting of layers of tetrafluoroethylene and hexafluoroethane.
Claim 15
Dependent Claim
57 words
The method of claim 7 further including the steps of: (a) depositing a preparation containing said polymeric material in a liquid vehicle onto said luminal surface; (b) removing said liquid vehicle by evaporation from said preparation to form a polymeric residue; and, (c) polymerizing further said polymeric residue to form a hydrophobic lining on said luminal surface.
Claim 16
Dependent Claim
44 words
The method of claim 13 wherein said lining is derived from a polymeric material made up of a polymer principally constituted by repeating units of a polyether-based polyurethane derived from a polytetramethylene ether glycol and a mixture of methylene diisocyanate and a diamine coupler.
Claim 17
Dependent Claim
23 words
The method of claim 13 or claim 14 wherein said steps (a)-(c) are repeated successively to form a plurality of discrete polymeric layers.
Claim 18
Dependent Claim
22 words
The method of claim 13 including the further step of depositing a polymeric layer defining a flow surface by glow discharge polymerization.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.