EP0152898A2
Expired / Lapsed
EP
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Process for encapsulation and encapsulated active material system(
Assignee: Massachusetts Institute of Technology
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Filing: 1985-02-12
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Granted: —
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Expires: 2005-02-12
Abstract
Abstract Capsules are formed having a liquifield core while avoiding capsule core gelatin by adding drops of a solution of either an anionic polymer composition or a cationic polymer composition to a solution of an ionic polymer of opposite charge. The drops contain an active ingredient such as a cell or microorganism capable of producing a biologically active product or can contain a biological or chemical composition. The interface of the ionic polymers form a permeable membrane surrounding the liquid drops.
Inventors
- 👤 Chokyun Rha
- 👤 Dolores Rodriguez-Sanchez
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 09:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5089
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
100 words
A process for producing a capsule having a liquid core from ionic polymers while avoiding gelation of said core which comprises: Forming a liquid droplet from an aqueous solution of a first ionic polymer selected from the group consisting of at least one anionic polymer and at least one cationic polymer and by contacting said droplet with a solution of at least one second ionic polymer, said second ionic polymer having an ionic charge opposite from said first ionic polymer and reacting said first and second polymer in contact with each other thereby to form a membrane encapsulating said droplet.
Claim 2
Dependent Claim
100 words
A process for producing a capsule having a liquid core from ionic polymers while avoiding gelation of said core which comprises: Forming a liquid droplet from an aqueous solution of a first ionic polymer selected from the group consisting of at least one anionic polymer and at least one cationic polymer and by contacting said droplet with a solution of at least one second ionic polymer, said second ionic polymer having an ionic charge opposite from said first ionic polymer and reacting said first and second polymer in contact with each other thereby to form a membrane encapsulating said droplet.
Claim 3
Dependent Claim
46 words
A process of claim 1 wherein said droplet contains an active material wherein said active material may be one of the group consisting of living cells or microorganisms or hybridoma cells or lymphocytes or bacteria or a biologically active compound or an enzyme or a hormone.
Claim 4
Dependent Claim
64 words
A process for producing a product from a living cell which comprises encapsulating said cell by the process of claim 1 and controlling the permeability of said membrane to prevent said product from permeating said membrane, collecting said encapsulated cell, rupturing said membrane and recovering said product, wherein said cell may be one of the group consisting of a hybridoma or a lymphocyte cell.
Claim 5
Dependent Claim
36 words
A process of claim 1, 2 or 3, wherein said anionic polymer is selected from the group consisting of alginate and carragenan and said cationic polymer is selected from the group consisting of chitosan and polylysine.
Claim 6
Dependent Claim
63 words
A process of anyone of claims 1 to 4, wherein a second membrane is formed by cross-linking a second anionic polymer to the anionic polymer portion of said first polymer by adding a divalent metal cation and said second anionic polymer after said first membrane is formed, said metal cation may be selected from the group consisting of calcium, barium and mixtures thereof.
Claim 7
Dependent Claim
43 words
A capsule comprising a polymeric membrane surrounding a liquid core wherein said membrane is formed by the interaction of at least one anionic polymer with at least one cationic polymer and wherein molecular chains comprising said polymer are oriented substantially whithin said membrane.
Claim 8
Dependent Claim
43 words
A capsule comprising a polymeric membrane surrounding a liquid core wherein said membrane is formed by the interaction of at least one anionic polymer with at least one cationic polymer and wherein molecular chains comprising said polymer are oriented substantially whithin said membrane.
Claim 9
Dependent Claim
19 words
The capsule of claim 6, wherein said cationic polymer forms the inner surface of said membrane adjacent liquid core.
Claim 10
Dependent Claim
20 words
The capsule of claim 6, wherein said anionic polymer forms the inner surface of said membrane adjacent said liquid core.
Claim 11
Dependent Claim
32 words
The capsule of claim 6, wherein said liquid core contains an active material, wherein said active material may be one of the group consisting of living cells, hybridoma cells and lymphocyte cells.
Claim 12
Dependent Claim
41 words
1 0 . The capsule of anyone of claims 6 to 9, wherein said anionic polymer is selceted from the group consisting of alginate and carragenan or wherein said cationic polymer is selected from the group consisting of chitosan and polylysine.
Claim 13
Dependent Claim
54 words
The capsule of anyone of claims 6 to 1 0 , which includes a second membrane formed by cross-linking the anionic polymer to the anionic polymer portion of said polymeric membrane with a divalent metal ion, wherein said divalent metal ion may be selected from the group consisting of calcium, barium and mixtures thereof.
References Cited (Backward Citations)
No citation records indexed.
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